Research progress on mechanism of acupuncture regulating amyloid⁃β in Alzheimer's disease

YANG Qianwen; FU Qinhui; PEI Jian

doi:10.16305/j.1007-1334.2023.2301031

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Research progress on mechanism of acupuncture regulating amyloid⁃β in Alzheimer's disease

更新时间：2023-07-15

- Research progress on mechanism of acupuncture regulating amyloid⁃β in Alzheimer's disease
- Shanghai Journal of Traditional Chinese Medicine Vol. 57, Issue 7, Pages: 88-93(2023)
- 作者机构：
  
  1.上海中医药大学附属龙华医院针灸科（上海 200032）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2023.2301031
  CLC：
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杨茜雯,傅勤慧,裴建.针刺调节阿尔茨海默病β⁃淀粉样蛋白机制的研究进展[J].上海中医药杂志,2023,57(7):88-93.

YANG Qianwen,FU Qinhui,PEI Jian.Research progress on mechanism of acupuncture regulating amyloid⁃β in Alzheimer's disease[J].Shanghai Journal of Traditional Chinese Medicine,2023,57(7):88-93.
杨茜雯,傅勤慧,裴建.针刺调节阿尔茨海默病β⁃淀粉样蛋白机制的研究进展[J].上海中医药杂志,2023,57(7):88-93. DOI： 10.16305/j.1007-1334.2023.2301031.

YANG Qianwen,FU Qinhui,PEI Jian.Research progress on mechanism of acupuncture regulating amyloid⁃β in Alzheimer's disease[J].Shanghai Journal of Traditional Chinese Medicine,2023,57(7):88-93. DOI： 10.16305/j.1007-1334.2023.2301031.

摘要

综述针刺调节阿尔茨海默病（AD）β-淀粉样蛋白（Aβ）机制的研究进展。Aβ斑块的形成、沉积与清除在AD的病理机制中发挥着重要作用。针刺通过调控Aβ切割、神经胶质细胞、线粒体及自噬系统、Tau蛋白磷酸化及神经原纤维缠结（NFT）形成，可减少Aβ的产生、沉积以及促进Aβ的清除，进而发挥神经功能保护作用。

Abstract

This paper reviews the research progress on the mechanism of acupuncture regulating amyloid-β （Aβ） in Alzheimer's disease （AD）. The production， deposition and clearance of Aβ plaques play an important role in the pathological mechanism of AD. By regulating Aβ cleavage， neuroglia， mitochondrial and autophagic systems， Tau protein phosphorylation and neurofibrillary tangles （NFT） formation， acupuncture can reduce Aβ production， deposition and promote Aβ clearance， thus exerting neuroprotective effects.

关键词

阿尔茨海默病β-淀粉样蛋白生物标志物针刺研究进展

Keywords

Alzheimer's diseaseamyloid-βbiomarkeracupunctureresearch progress

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