Research progress in monomers of traditional Chinese herbal medicine targeting PI3K/Akt/mTOR signaling pathway to prevent and treat diabetic nephropathy

WANG Wanting; XU Ying; SHAO Minghai

doi:10.16305/j.1007-1334.2023.2301019

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Research progress in monomers of traditional Chinese herbal medicine targeting PI3K/Akt/mTOR signaling pathway to prevent and treat diabetic nephropathy

更新时间：2023-09-19

- Research progress in monomers of traditional Chinese herbal medicine targeting PI3K/Akt/mTOR signaling pathway to prevent and treat diabetic nephropathy
- Shanghai Journal of Traditional Chinese Medicine Vol. 57, Issue 10, Pages: 83-88(2023)
- 作者机构：
  
  1.上海中医药大学附属曙光医院肾病科（上海 201203）
  2.上海中医药大学中医肾病研究所（上海 201203）
  3.肝肾疾病病证教育部重点实验室（上海 201203）
  4.上海市中医临床重点实验室（上海 201203）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2023.2301019
  CLC：
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王婉婷,许颖,邵命海.中药单体靶向PI3K/Akt/mTOR信号通路防治糖尿病肾病的研究进展[J].上海中医药杂志,2023,57(10):83-88.

WANG Wanting,XU Ying,SHAO Minghai.Research progress in monomers of traditional Chinese herbal medicine targeting PI3K/Akt/mTOR signaling pathway to prevent and treat diabetic nephropathy[J].Shanghai Journal of Traditional Chinese Medicine,2023,57(10):83-88.
王婉婷,许颖,邵命海.中药单体靶向PI3K/Akt/mTOR信号通路防治糖尿病肾病的研究进展[J].上海中医药杂志,2023,57(10):83-88. DOI： 10.16305/j.1007-1334.2023.2301019.

WANG Wanting,XU Ying,SHAO Minghai.Research progress in monomers of traditional Chinese herbal medicine targeting PI3K/Akt/mTOR signaling pathway to prevent and treat diabetic nephropathy[J].Shanghai Journal of Traditional Chinese Medicine,2023,57(10):83-88. DOI： 10.16305/j.1007-1334.2023.2301019.

摘要

综述中药单体靶向磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白（PI3K/Akt/mTOR）信号通路防治糖尿病肾病（DN）的研究进展。研究表明，PI3K/Akt/mTOR信号通路可以抑制炎症反应、氧化应激、细胞凋亡和自噬，在DN发生发展中起着重要作用；中药单体（黄芩苷、石斛碱、姜黄素、三七皂苷R1、桔梗皂苷D、蛇床子素）可通过靶向调控该信号通路有效防治DN。

Abstract

This article reviewed the research progress in monomers of traditional Chinese herbal medicine targeting PI3K/Akt/mTOR signaling pathway to prevent and treat diabetic nephropathy （DN）. Studies have shown that PI3K/Akt/mTOR signaling pathway can inhibit inflammatory reaction， oxidative stress， apoptosis and autophagy， and plays an important role in the development and progression of DN. Monomers of traditional Chinese herbal medicine （baicalin， dendrobine， curcumin， notoginsenoside R1， platycodin D and osthole） can effectively prevent and treat DN by regulating PI3K/Akt/mTOR signaling pathway.

关键词

糖尿病肾病中药作用机制研究进展

Keywords

diabetic nephropathytraditional Chinese herbal medicinemechanism of actionresearch progress

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