Discussion on traditional Chinese medicine pathogenesis of brain metastases from lung cancer based on theory of “lung⁃brain correlation”

LIU Fangfang; JIANG Yi; CAI Yuqing; LIU Lingshuang

doi:10.16305/j.1007-1334.2023.2211065

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Discussion on traditional Chinese medicine pathogenesis of brain metastases from lung cancer based on theory of “lung⁃brain correlation”

更新时间：2023-07-15

- Discussion on traditional Chinese medicine pathogenesis of brain metastases from lung cancer based on theory of “lung⁃brain correlation”
- Shanghai Journal of Traditional Chinese Medicine Vol. 57, Issue 7, Pages: 1-4(2023)
- 作者机构：
  
  1.上海中医药大学（上海 201203）
  2.上海中医药大学附属龙华医院（上海 200032）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2023.2211065
  CLC：
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刘芳芳,姜怡,蔡雨晴,等.基于“肺脑相系”理论探讨肺癌脑转移的中医发病机制[J].上海中医药杂志,2023,57(7):1-4.

LIU Fangfang,JIANG Yi,CAI Yuqing,et al.Discussion on traditional Chinese medicine pathogenesis of brain metastases from lung cancer based on theory of “lung⁃brain correlation”[J].Shanghai Journal of Traditional Chinese Medicine,2023,57(7):1-4.
刘芳芳,姜怡,蔡雨晴,等.基于“肺脑相系”理论探讨肺癌脑转移的中医发病机制[J].上海中医药杂志,2023,57(7):1-4. DOI： 10.16305/j.1007-1334.2023.2211065.

LIU Fangfang,JIANG Yi,CAI Yuqing,et al.Discussion on traditional Chinese medicine pathogenesis of brain metastases from lung cancer based on theory of “lung⁃brain correlation”[J].Shanghai Journal of Traditional Chinese Medicine,2023,57(7):1-4. DOI： 10.16305/j.1007-1334.2023.2211065.

摘要

脑是肺癌最易发生转移的部位之一，探析肺癌脑转移的发病机制对肺癌远处转移的防治和预后具有重要意义。基于“肺脑相系”理论，结合肺、脑的生理和病理特点，从气机、五行、藏象、经络等角度阐述肺与脑的相关性，探讨肺癌脑转移的病机，进而为从肺论治肺癌脑转移提供理论依据。

Abstract

Lung cancer is most likely to metastasize to the brain. It is important to explore the pathogenesis of brain metastasis of lung cancer for the prevention， treatment and prognosis of distant metastasis of lung cancer. Based on the theory of “lung-brain correlation”， we aim to explain the correlation between the lungs and brain in terms of qi movement， five elements， visceral manifestations， as well as channels and collaterals， explore the pathogenesis of lung cancer brain metastasis and provide a theoretical basis for the treatment of lung cancer brain metastasis from the lungs by considering the physiological and pathological characteristics of the lungs and brain.

关键词

肺癌肿瘤转移肺脑相系中医病机中医药疗法

Keywords

lung cancertumor metastasislung-brain correlationtraditional Chinese medicine pathogenesistraditional Chinese medicine therapy

references

ZHENG R， ZHANG S， ZENG H， et al. Cancer incidence and mortality in China， 2016［J］. J Natl Cancer Cent， 2022， 2（1）： 1-9.

ZENG H， CHEN W， ZHENG R， et al. Changing cancer survival in China during 2003-15： a pooled analysis of 17 population-based cancer registries［J］. Lancet Glob Health， 2018， 6（5）： e555-e567.

中国医师协会肿瘤医师分会，中国医疗保健国际交流促进会肿瘤内科分会. 肺癌脑转移中国治疗指南（2021年版）［J］.中华肿瘤杂志，2021， 43（3）： 269-281.

PAGET S. The distribution of secondary growths in cancer of the breast. 1889［J］. Cancer Metastasis Rev， 1989， 8（2）： 98-101.

EWING J. Neoplastic diseases［M］. 6th ed. Philadelphia： WB Saunders， 1928： 65-68.

BAJINKA O， SIMBILYABO L， TAN Y， et al. Lung-brain axis［J］.Crit Rev Microbiol， 2022， 48（3）： 257-269.

孙广仁，郑洪新. 中医基础理论［M］. 北京：中国中医药出版社，2012： 142.

BOIRE A， BRASTIANOS P K， GARZIA L， et al. Brain metastasis［J］. Nat Rev Cancer， 2020， 20（1）： 4-11.

HEUER J F， PELOSI P， HERMANN P， et al. Acute effects of intracranial hypertension and ARDS on pulmonary and neuronal damage： a randomized experimental study in pigs［J］. Intensive Care Med， 2011， 37（7）： 1182-1191.

STEVENS R D， PUYBASSET L. The brain-lung-brain axis［J］. Intensive Care Med， 2011， 37（7）： 1054-1056.

ODOARDI F， SIE C， STREYL K， et al. T cells become licensed in the lung to enter the central nervous system［J］.Nature， 2012， 488（7413）： 675-679.

BELL J S， SPENCER J I， YATES R L， et al. Invited Review： From nose to gut - the role of the microbiome in neurological disease［J］. Neuropathol Appl Neurobiol， 2019， 45（3）： 195-215.

HOSANG L， CANALS R C， VAN DER FLIER F J， et al. The lung microbiome regulates brain autoimmunity［J］. Nature， 2022， 603（7899）： 138-144.

王磊. 朝医方山药补肺元汤合熊胆散抗脑缺血再灌注损伤作用的实验研究［D］. 延吉：延边大学，2019.

王晋平，唐农，胡跃强，等. 益肺宣肺降浊方对血管性痴呆大鼠海马超微结构以及cAMP/PKA-CREB信号通路的影响［J］. 辽宁中医杂志，2016， 43（2）： 404-407.

吴子建，蔡荣林，徐春生，等. 心经与肺经在大脑相对特异性的fMRI研究［J］. 中国针灸，2011， 31（6）： 529-534.

磨炼，慕晓艳，李和根.中药改善非小细胞肺癌患者EGFR-TKIs获得性耐药研究现状及其中医病机探析［J］. 上海中医药杂志，2023， 57（4）： 24-28.

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