Objective,2,To observe the clinical efficacy and safety of combining chemotherapy with Sanleng Xiaoliu Mixture in the treatment of advanced gastric cancer of intermingled phlegm and stasis syndrome.,Methods,2,Ninety-two patients with advanced gastric cancer of intermingled phlegm and stasis syndrome were divided into treatment group （,n,=44） and control group （,n,=48） according to their wishes. The control group was given chemotherapy （fluorouracil as the basic regimen）， while the treatment group was treated with Sanleng Xiaoliu Mixture in addition to the treatment measures of the control group. A cycle of chemotherapy is 21 days. The basic course of chemotherapy was 4 cycles in both groups， and the follow-up treatment could be continued to 6-8 cycles as appropriate. At the end of the basic course of treatment， syndrome therapeutic evaluation and solid tumor evaluation were conducted， and the changes in Karnofsky Performance Status （KPS） score were compared. The chemotherapy cycles were recorded， and the changes in TCM syndrome scores before treatment and at the 22nd and 85th days of treatment were compared between the two groups， as well as the incidence of toxic reactions during the basic course of treatment.,Results,2,①The total effective rate according to the TCM syndrome therapeutic evaluation was 77.3% in the treatment group and 50.0% in control group； the TCM syndrome therapeutic evaluation in the treatment group was better than that in the control group （,P,<,0.05）. ②The difference in the efficacy for solid tumors between the two groups was not statistically significant （,P,>,0.05）. ③In the treatment group， the scores of epigastralgia， nausea and vomiting， poor appetite， heavy sensation in the body and limbs and the total TCM syndrome score decreased on day 22 of treatment （,P,<,0.05），while the total TCM syndrome score decreased in the control group（,P,<,0.05）.And the differences in the scores of epigastralgia， nausea and vomiting， poor appetite， heavy sensation in the body and limbs and total TCM syndrome score were statistically significant on day 85 of treatment between the two groups（,P,<,0.05）. ④After treatment， the KPS score increased in both groups （,P,<,0.05）； and the KPS score was higher in the treatment group than that in the control group （,P,<,0.05）. ⑤There was no statistically significant difference between the two groups in terms of the completion of chemotherapy cycles （,P,>,0.05）. ⑥The incidence of peripheral neurotoxicity in the treatment group was lower than that in the control group （,P,<,0.05）， but the difference in the incidence of hematologic toxicity and gastrointestinal toxicity between the two groups was not statistically significant （,P,>,0.05）.,Conclusion,2,Sanleng Xiaoliu Mixture with chemotherapy has a good clinical effect on patients with advanced gastric cancer of intermingled phlegm and stasis syndrome as it can significantly improve TCM symptoms and quality of life of patients， and reduce the toxic reaction of chemotherapy.