Explore relationship between gut microbiota and hypertension based on the theory of “the heart and small intestine forming an exterior and interior relationship”
|更新时间:2023-08-05
|
Explore relationship between gut microbiota and hypertension based on the theory of “the heart and small intestine forming an exterior and interior relationship”
Shanghai Journal of Traditional Chinese MedicineVol. 57, Issue 8, Pages: 57-62(2023)
ZHU Wen,XIE Fengqun,CHENG Jie,et al.Explore relationship between gut microbiota and hypertension based on the theory of “the heart and small intestine forming an exterior and interior relationship”[J].Shanghai Journal of Traditional Chinese Medicine,2023,57(8):57-62.
ZHU Wen,XIE Fengqun,CHENG Jie,et al.Explore relationship between gut microbiota and hypertension based on the theory of “the heart and small intestine forming an exterior and interior relationship”[J].Shanghai Journal of Traditional Chinese Medicine,2023,57(8):57-62. DOI: 10.16305/j.1007-1334.2023.2209087.
Explore relationship between gut microbiota and hypertension based on the theory of “the heart and small intestine forming an exterior and interior relationship”
The gut microbiota is an important factor in the development of hypertension. According to traditional Chinese medicine theory, the heart and small intestine are interconnected in meridians, cooperate with each other physiologically, and influence each other pathologically, i.e., “the heart and small intestine are exteriorly and interiorly interrelated”. Based on the theory of “the heart and small intestine forming an exterior and interior relationship” and review of relevant literature, the correlation between gut microbiota and hypertension, and the preventive and therapeutic effects of traditional Chinese herbal medicines on hypertension through regulating gut microbiota were discussed, with a view to providing ideas for the clinical treatment of hypertension.
关键词
高血压肠道菌群心与小肠相表里中药中医药疗法
Keywords
hypertensiongut microbiotathe heart and small intestine forming an exterior and interior relationshiptraditional Chinese herbal medicinetraditional Chinese medicine therapy
SUGAHARA H, ODAMAKI T, FUKUDA S, et al. Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community[J]. Sci Rep, 2015, 5: 13548.
JrHILLS R D, PONTEFRACT B A, MISHCON H R, et al. Gut microbiome: profound implications for diet and disease[J]. Nutrients, 2019, 11(7) :1613.
VAN HECKE T, DE VRIEZE J, BOON N, et al. Combined consumption of beef-based cooked mince and sucrose stimulates oxidative stress, cardiac hypertrophy, and colonic outgrowth of desulfovibrionaceae in rats[J]. Mol Nutr Food Res, 2019, 63(2): e1800962.
PALMU J, SALOSENSAARI A, HAVULINNA A S, et al. Association between the gut microbiota and blood pressure in a population cohort of 6953 individuals[J]. J Am Heart Assoc, 2020, 9(15): e016641.
YAN Q, GU Y, LI X, et al. Alterations of the gut microbiome in hypertension[J]. Front Cell Infect Microbiol, 2017, 7: 381.
VIEIRA-ROCHA M S, SOUSA J B, RODRIGUEZ-RODRIGUEZ P, et al. Insights into sympathetic nervous system and GPCR interplay in fetal programming of hypertension: a bridge for new pharmacological strategies[J]. Drug Discov Today, 2020, 25(4): 739-747.
TAN J K, MCKENZIE C, MARIÑO E, et al. Metabolite-sensing G protein-coupled receptors-facilitators of diet-related immune regulation[J]. Annu Rev Immunol, 2017, 35(1): 371-402.
PLUZNICK J L, PROTZKO R J, GEVORGYAN H, et al. Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation[J]. Proc Natl Acad Sci USA, 2013, 110(11): 4410-4415.
PLUZNICK J. A novel SCFA receptor, the microbiota, and blood pressure regulation[J]. Gut microbes, 2014, 5(2): 202-207.
XIE G, YAN A, LIN P, et al. Trimethylamine N-oxide-a marker for atherosclerotic vascular disease[J]. Rev Cardiovasc Med, 2021, 22(3): 787-797.
GE X, ZHENG L, ZHUANG R, et al. The gut microbial metabolite trimethylamine N-oxide and hypertension risk:a systematic review and dose-response meta-analysis[J]. Adv Nutr, 2020, 11(1): 66-76.
TEFT W A, MORSE B L, LEAKE B F, et al. Identification and characterization of trimethylamine-N-oxide uptake and efflux transporters[J]. Mol Pharm, 2017, 14(1): 310-318.
DURGAN D J, GANESH B P, COPE J L, et al. Role of the gut microbiome in obstructive sleep apnea-induced hypertension[J]. Hypertension, 2016, 67(2): 469-474.
GRÜNER N, MATTNER J. Bile acids and microbiota: multifaceted and versatile regulators of the liver-gut axis[J]. Int J Mol Sci, 2021, 22(3): 1397-1397.
JOYCE S A, GAHAN C G. Disease-associated changes in bile acid profiles and links to altered gut microbiota[J]. Dig Dis, 2017, 35(3): 169-177.
PARKS D J, BLANCHARD S G, BLEDSOE R K, et al. Bile acids: natural ligands for an orphan nuclear receptor[J]. Science, 1999, 284(5418): 1365-1368.
BÜHLER H, PERSCHEL F H, FITZNER R, et al. Endogenous inhibitors of 11 beta-OHSD: existence and possible significance[J]. Steroids, 1994, 59(2): 131-135.
YAU M, HAIDER S, KHATTAB A, et al. Clinical, genetic, and structural basis of apparent mineralocorticoid excess due to 11β-hydroxysteroid dehydrogenase type 2 deficiency[J]. Proc Natl Acad Sci U S A, 2017, 114(52): E11248-E11256.
MADHUR M S, LOB H E, MCCANN L A, et al. Interleukin 17 promotes angiotensin Ⅱ-induced hypertension and vascular dysfunction[J]. Hypertension, 2010, 55(2): 500-507.
ROBLES-VERA I, TORAL M, DE LA VISITACIÓN N, et al. The probiotic lactobacillus fermentum prevents dysbiosis and vascular oxidative stress in rats with hypertension induced by chronic nitric oxide blockade[J]. Mol Nutr Food Res, 2018, 62(19): 1-13.
KIM S, GOEL R, KUMAR A, et al. Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure[J]. Clinical science, 2018, 132(6): 701-718.
VAN BEUSECUM J P, BARBARO N R, MCDOWELL Z, et al. High salt activates CD11c+ antigen-presenting cells via SGK (serum glucocorticoid kinase) 1 to promote renal inflammation and salt-sensitive hypertension[J]. Hypertension, 2019, 74(3): 555-563.
WILCK N,MATUS M G,KEARNEY S M,et al. Salt-responsive gut commensal modulates TH17 axis and disease[J]. Nature, 2017, 551 (7682): 585-589.
DABKE K, HENDRICK G, DEVKOTA S. The gut microbiome and metabolic syndrome[J]. J Clin Invest, 2019, 129(10): 4050-4057.
PICKARD J M, ZENG M Y, CARUSO R, et al. Gut microbiota: role in pathogen colonization, immune responses, and inflammatory disease[J]. Immunol Rev, 2017, 279(1): 70-89.
VALLIANOU N G, GELADARI E, KOUNATIDIS D. Microbiome and hypertension: where are we now?[J]. J Cardiovasc Med, 2020, 21(2): 83-88.
BARROWS I R, RAMEZANI A, RAJ D S. Inflammation, immunity, and oxidative stress in hypertension-partners in crime?[J]. Adv Chronic Kidney Dis, 2019, 26(2): 122-130.
TORAL M, ROBLES-VERA I, DE LA VISITACIÓN N, et al. Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats[J]. Acta Physiol, 2019, 227(1): e13285.
KARBACH S H, SCHÖNFELDER T, BRANDÃO I, et al. Gut microbiota promote angiotensin Ⅱ-induced arterial hypertension and vascular dysfunction[J]. J Am Heart Assoc, 2016, 5(9): e003698.
SANTISTEBAN M M, QI Y, ZUBCEVIC J, et al. Hypertension-linked pathophysiological alterations in the gut[J]. Circ Res, 2017, 120(2): 312-323.
LA SALVIA S, MUSANTE L, LANNIGAN J, et al. T cell-derived extracellular vesicles are elevated in essential HTN[J]. Am J Physiol Renal Physiol, 2020, 319(5): F868-F875.
BARBARO N R , FOSS J D, KR YSHTAL D O, et al. Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension[J]. Cell Rep, 2017, 21(4): 1009-1020.
ELIJOVICH F, LAFFER C L, SAHINOZ M, et al. The gut microbiome, inflammation, and salt-sensitive hypertension[J]. Curr Hypertens Rep, 2020, 22(10): 79.
XU J, CHEN H B, LI S L, et al. Understanding the molecular mechanisms of the interplay between herbal medicines and gut microbiota[J]. Med Res Rev, 2017, 37(5): 1140-1185.
WU J, NAKASHIMA S, NAKAMURA S, et al. Effects of Sanoshashinto on left ventricular hypertrophy and gut microbiota in spontaneously hypertensive rats[J]. J Nat Med, 2020, 74(2): 482-486.
YU X, ZHANG X, JIN H, et al. Zhengganxifeng Decoction affects gut microbiota and reduces blood pressure via renin-angiotensin system[J]. Biol Pharm Bull, 2019, 42(9): 1482-1490.
Research progress on bile acid metabolism and its receptors regulating intestinal immunity in ulcerative colitis and traditional Chinese herbal medicine intervention
Bidirectional interaction between neuroinflammation and gut microbiota after intracerebral hemorrhage
Traditional Chinese medicine treatment for Alzheimer’s disease based on the microbiota⁃brain⁃gut axis
Research progress on mechanisms of traditional Chinese medicine in improving obesity and its related metabolic diseases through gut microbiota
Research progress on prevention and treatment of hypertensive left ventricular hypertrophy by traditional Chinese medicine
Related Author
No data
Related Institution
Department of Anorectology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine
Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Institute of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Shandong University of Traditional Chinese Medicine, Ji’nan
The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji’nan