Clinical study on intervention of Fuzheng Hejie Recipe in children with asymptomatic infection of SARS⁃CoV⁃2 Omicron variant

HUANG Lirong; LIU Yazun; XUE Zheng; YOU Yannan; YANG Yan; ZHOU Huan; GENG Lina; PIAO Xiang; LIU Xiao; HU Mingge; WU Mingyun; WANG Yajuan; ZHOU Lili; SHEN Shiping; HAN Zhaopeng; WANG Peng

doi:10.16305/j.1007-1334.2022.2209049

您当前的位置：

首页 >

文章列表页 >

Clinical study on intervention of Fuzheng Hejie Recipe in children with asymptomatic infection of SARS⁃CoV⁃2 Omicron variant

更新时间：2022-12-22

- Clinical study on intervention of Fuzheng Hejie Recipe in children with asymptomatic infection of SARS⁃CoV⁃2 Omicron variant
- Shanghai Journal of Traditional Chinese Medicine Vol. 56, Issue 12, Pages: 53-56(2022)
- 作者机构：
  
  1.上海中医药大学附属市中医医院儿科（上海 200071）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2022.2209049
  CLC：
扫描看全文
黄莉荣,刘亚尊,薛征,等.扶正和解方干预新型冠状病毒奥密克戎变异株无症状感染儿童的临床研究[J].上海中医药杂志,2022,56(12):53-56.

HUANG Lirong,LIU Yazun,XUE Zheng,et al.Clinical study on intervention of Fuzheng Hejie Recipe in children with asymptomatic infection of SARS⁃CoV⁃2 Omicron variant[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(12):53-56.
黄莉荣,刘亚尊,薛征,等.扶正和解方干预新型冠状病毒奥密克戎变异株无症状感染儿童的临床研究[J].上海中医药杂志,2022,56(12):53-56. DOI： 10.16305/j.1007-1334.2022.2209049.

HUANG Lirong,LIU Yazun,XUE Zheng,et al.Clinical study on intervention of Fuzheng Hejie Recipe in children with asymptomatic infection of SARS⁃CoV⁃2 Omicron variant[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(12):53-56. DOI： 10.16305/j.1007-1334.2022.2209049.

摘要

目的,2,观察扶正和解方治疗新型冠状病毒（SARS-CoV-2）奥密克戎变异株无症状感染儿童的临床疗效。,方法,2,将66例SARS-CoV-2奥密克戎变异株无症状感染儿童随机分为治疗组与对照组，每组33例。治疗组予中药扶正和解方颗粒剂，对照组予重组人干扰素α-2b喷雾剂，两组疗程均为7 d。观察用药安全性，比较SARS-CoV-2检测核酸转阴时间、7 d内核酸转阴率。,结果,2,①试验期间，无病例脱落或剔除。②治疗组核酸转阴时间为（9.33±3.07）d，对照组核酸转阴时间为（11.85±2.39）d；组间核酸转阴时间比较，差异有统计学意义（,P,<,0.05）。③组间比较，治疗组自第2天开始至第7天核酸转阴率均明显高于对照组（,P,<,0.05）。④试验期间，两组患儿均未出现过敏反应、恶心、呕吐等，肝肾功能指标均未见异常。,结论,2,对于SARS-CoV-2奥密克戎变异株无症状感染儿童，扶正和解方可显著缩短其核酸转阴时间，提高核酸转阴率，且安全性较好。

Abstract

Objective,2,To observe the clinical efficacy of Fuzheng Hejie Recipe in the treatment of asymptomatic children infected with SARS-CoV-2 Omicron variant.,Methods,2,Sixty-six asymptomatic children infected with SARS-CoV-2 Omicron variant were randomly divided into a treatment group （,n,=33） and a control group （,n,=33）. The treatment group was administered with granules of Fuzheng Hejie Recipe and the control group was treated with the recombinant human interferon alpha-2b spray. The treatment course was 7 d for both groups. The safety of medication was observed， and the negative conversion time of nucleic acid test （NAT） for SARS-CoV-2 and the negative conversion rate of NAT within 7 d were compared.,Results,2,①No patient dropouts or patient discontinuers were found during the trial. ②The negative conversion time of NAT was （9.33±3.07） d in the treatment group and （11.85±2.39） d in the control group； There was statistically significant difference in the negative conversion time of NAT between the two groups （,P,<,0.05）. ③On day 2 through 7， the negative conversion rate in the treatment group was significantly higher than that in the control group （,P,<,0.05）. ④During the trial， none of the infected children had allergic reactions， nausea or vomiting， etc.， and no abnormality was found in the liver and kidney function test in both groups.,Conclusion,2,For asymptomatic children infected with SARS-CoV-2 Omicron variant， Fuzheng Hejie Recipe can significantly shorten the negative conversion time and increase the negative conversion rate of NAT with good safety.

关键词

新型冠状病毒肺炎新型冠状病毒奥密克戎变异株儿童扶正和解方中医药疗法临床试验

Keywords

COVID-19SARS-CoV-2Omicron variantchildrenFuzheng Hejie Recipetraditional Chinese medicine therapyclinical trial

references

世界卫生组织. 儿童和青少年的COVID-19疾病［EB/OL］.（2021-09-29）［2022-08-02］. https：//apps.who.int/iris/bitstream/handle/10665/345575/WHO-2019-nCoV-Sci-Brief-Children-and adolescents-2021.1-chi.pdfhttps://apps.who.int/iris/bitstream/handle/10665/345575/WHO-2019-nCoV-Sci-Brief-Children-andadolescents-2021.1-chi.pdf.

TIAN D， SUN Y， XU H， et al. The emergence and epidemic characteristics of the highlymutated SARS-CoV-2 Omicron variant［J］. J Med Virol， 2022， 94（6）： 2376-2383.

ZHANG X， ZHANG W， CHEN S. Shanghai’s lifesaving efforts against the current omicron wave of the COVID-19 pandemic［J］. Lancet， 2022， 399（10340）： 2011-2012.

MAKS K J， WHITAKER M， ANGLIN O， et al. Hospitalizations of children and adolescents with laboratory-confirmed COVID-19-COVID-NET， 14 states， July 2021-January 2022［J］. MMWR Morb Mortal Wkly Rep， 2022， 71（7）： 271-278.

HOBBS C V， DROBENIUC J， KITTLE T， et al. Estimated SARS-CoV-2 seroprevalence among persons aged <18 years—Mississippi， May-September 2020［J］. MMWR Morb Mortal Wkly Rep， 2021， 70（9）： 312-315.

LI F， LI Y Y， LIU M J， et al. Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity in Wuhan： a retrospective observational study［J］. Lancet Infect Dis， 2021， 21（5）： 617-628.

DEBIASI R L， DELANEY M. Symptomatic and asymptomatic viral shedding in pediatric patients infected with severe acute respiratory syndrome coronavirus 2 （SARS-CoV-2）： under the surface［J］. JAMA Pediatr， 2021， 175（1）： 16-18.

吴尊友.新型冠状病毒肺炎无症状感染者在疫情传播中的作用与防控策略［J］. 中华流行病学杂志，2020， 41（6）： 801-805.

薛艳，张炜，徐贵华，等. 湿瘟为病，疏利透达——上海地区新型冠状病毒肺炎中医临床证治探析［J］. 上海中医药杂志，2020， 54（3）： 16-20.

吴雨沁，邹璐，喻晓，等. 中西医结合治疗新型冠状病毒肺炎的系统评价［J］. 上海中医药杂志，2020， 54（6）： 29-36.

上海市儿童新型冠状病毒变异株感染中医药防治专家共识（2022春季版）编写组.上海市儿童新型冠状病毒变异株感染中医药防治专家共识（2022春季版）［J］. 上海中医药杂志，2022， 56（8）： 4-6.

国家卫生健康委员会办公厅，国家中医药管理局办公室.新型冠状病毒肺炎诊疗方案（试行第九版）［J］.中国医药，2022， 17（4）： 481-487.

蒋荣猛，谢正德，姜毅，等. 儿童新型冠状病毒感染诊断、治疗和预防专家共识（第四版）［J］. 中华实用儿科临床杂志，2022， 37（14）： 1053-1065.

CALLAWAY E. Are COVID surges becoming more predictable？ New Omicron variants offer a hint［J］. Nature， 2022，605（7909）：204-206.

WANG X S， CHANG H L， TIAN H， et al. Epidemiological and clinical features of SARS-CoV-2 infection in children during the outbreak of Omicron Variant in Shanghai， March 7-March 31，2022.［EB/OL］. （2022-05-02）［2022-08-20］. https：//www.medrxiv.org/content/10.1101/2022.04.28.22274421v1https://www.medrxiv.org/content/10.1101/2022.04.28.22274421v1.

HAN B H， SONG Y F， LI C G， et al. Safety， tolerability， and immunogenicity of an inactivated SARS-CoV-2 vaccine （CoronaVac） in healthy children and adolescents： a double-blind， randomised， controlled， phase 1/2 clinical trial［J］. Lancet Infect Dis， 2021， 21（12）： 1645-1653.

谌攀，饶鸿宇，吴灏，等. 基于分子对接法和网络药理学揭示小柴胡汤防治新型冠状病毒肺炎的活性成分及作用机制［J］. 中国现代应用药学，2021， 38（21）： 2665-2674.

Views

587

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Experience of Yu Jian in treating children with SARS⁃CoV⁃2 infection——A proven critical case

Shanghai expert consensus on traditional Chinese medicine prevention and treatment for children infected with Omicron variant of COVID⁃19 （Spring 2022 Edition）

Thoughts on practice and management of clinical research of traditional Chinese medicine during normalization stage of prevention and control of COVID⁃19

Expert consensus on traditional dog⁃days acupoint application for children during the normalization stage of prevention and control of COVID⁃19 in Shanghai （2022 edition）

Clinical observation on Ganjiang Xiaochaihu Decoction in treating patients with mild infection of COVID⁃19 Omicron variant

Related Author

No data

Related Institution

Department of Traditional Chinese Medicine， Fudan University of Children’s Hospital

Department of Intensive Care Unit， Fudan University of Children’s Hospital

Department of Infectious Disease， Fudan University of Children’s Hospital

Department of Respiratory， Fudan University of Children’s Hospital

Shanghai Municipal Hospital of Traditional Chinese Medicine， Shanghai University of Traditional Chinese Medicine

⁰