Objective,2,To analyze the traditional Chinese medicine （TCM） syndrome characteristics in Omicron variant infected patients with chronic kidney disease （CKD） in Shanghai.,Methods,2,Cases of Omicron variant infected CKD patients who were hospitalized in Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine were included. The baseline data such as gender， age， underlying diseases and CKD stages， and TCM symptom information such as cough， fever， fatigue， anorexia， sore throat， dry mouth， bitter taste， loose stool and constipation， as well as tongue and pulse condition were collected to analyze TCM syndrome characteristics. The patients’ lung CT images were reviewed through the medical record system to determine the severity of COVID-19 from the perspective of western medicine and the TCM syndrome differentiation was further conducted in patients with different severity of COVID-19.,Results,2,①A total of 367 hospitalized cases with Omicron infection were screened， and 53 cases with CKD were included for research. Among 53 cases， patients were classified as CKD stage G3a， G2， G1 or G5， and most of them were the elderly over 80 years old. There were more female patients than male ones， and one of the most common underlying diseases was hypertension. ②The common clinical symptoms were cough （62.3%）， anorexia （47.2%）， fatigue （45.3%）， bitter taste （37.7%） and fever （34.0%）. ③In terms of tongue condition， 60.4% of the patients had fat tongue body， 62.3% had red tongue color， 43.4% had thin tongue coating and 66.0% had yellow tongue coating； In terms of pulse condition， 56.6% of the patients had slippery pulse and 52.8% had fine pulse. ④Among 53 patients， there were 21 mild cases， 29 moderate cases， 2 severe cases and 1 critical case. ⑤The most common TCM syndromes of mild and moderate cases were damp-heat accumulating in the lungs syndrome （34.0%） and damp-toxin stagnating in the lungs syndrome （32.1%）； There was one severe case identified as flaring heat in qifen and yingfen syndrome （1.9%） and the other as pestilential toxicity blocking the lungs syndrome （1.9%）； The critical case met the syndrome differentiation criteria of inner blocking causing collapse syndrome （1.9%）.,Conclusions,2,In our research， the majority of patients with COVID-19 Omicron variant infection combined with chronic kidney disease are the elderly with severe underlying diseases， and their clinical manifestations are mainly respiratory， together with systemic symptoms. Mild cases mainly have damp-heat accumulating in the lungs syndrome， moderate cases mainly have damp-toxin stagnating in the lungs syndrome， severe cases can be identified as pestilential toxicity blocking the lungs syndrome and flaring heat in qifen and yingfen syndrome， and critical cases can be identified as inner blocking causing collapse syndrome.