Objective,2,To evaluate the efficacy and safety of Prof. Cai Gan’s treatment of chronic atrophic gastritis （CAG） in the real world.,Methods,2,A total of 316 patients with CAG received Prof. Cai Gan’s traditional Chinese medicine （TCM） treatment （mainly based on Xinwei Decoction）for at least 6 months. TCM symptom scores after 2 and 4 weeks of treatment， as well as gastroscopy and gastric mucosa histopathology after 6 months of treatment were observed； the scores of MYMOP2， SAS and SDS before treatment were compared with those after 2 and 4 weeks of treatment， respectively； and the safety evaluation was also performed.,Results,2,①The total effective rate of TCM symptom was 95.8% after 2 weeks of treatment and reached 99.4% after 4 weeks of treatment. The improvement of TCM symptoms after 4 weeks of treatment was better than that after 2 weeks of treatment， and the difference was statistically significant （,P,<,0.05）. ②The scores of MYMOP2， SAS and SDS were lower after 2 and 4 weeks of treatment than those before treatment （,P,<,0.05）； The scores of MYMOP2， SAS and SDS after 4 weeks of treatment were lower than those after 2 weeks of treatment （,P,<,0.05）. ③After 6 months of treatment， the gastroscopic pathological effective rate reached 71.2%， the total effective rate of pathological atrophy reached 54.8%， and that of pathological intestinal metaplasia reached 74.0%. ④No adverse reactions occurred during the treatment. There were no significant changes in the routine blood test， and the liver and kidney function test.,Conclusion,2,In the real world， Prof. Cai Gan has achieved a satisfactory result in the treatment of CAG， as his therapy can significantly alleviate the indigestion symptoms of patients， effectively improve the pathological atrophy of gastric tissue and intestinal metaplasia in CAG patients with the prolongation of treatment， and simultaneously have good long-term safety.