The increasing number of patients suffering from “intractable and miscellaneous diseases” has led to the study and discussion on the correlation between endogenous toxins and chronic intractable diseases. It is believed that “accumulation and damage of endogenous toxins” has become an important etiological and pathological factor of modern “intractable diseases” due to the influence of external environmental hazards and changes in lifestyle. As a relatively independent and objective being of pathogenic qi， endogenous toxins must have specific clinical manifestations， presenting the syndrome features of “accumulation of toxins” and “gradual manifestation of symptoms”. The connotation of pathogenic toxins changes with the development of the times. Since diseases caused by endogenous toxins are mostly chronic intractable diseases， the first-line and necessary treatment is to resolve toxins. Therefore， the connotation of toxin-resolving therapy must keep pace with the times to let its clinical value keep on shining today.