Objective,2,To explore and analyze the medication rules for the treatment of stroke in ,Puji Fang, based on the Traditional Chinese Medicine Inheritance Support System （tcmiss） （V2.5） software.,Methods,2,The prescriptions for the treatment of stroke in ,Puji Fang, were compiled and fed into the tcmiss （V2.5） to build a database， and then relevant statistical analysis tools of the software were used for data mining to analyze the medication rules in prescriptions.,Results,2,①There were 47 prescriptions that met the inclusion criteria， involving 137 traditional Chinese herbal medicines （TCHMS）. ②There were 27 TCHMs with frequencies greater than or equal to 5， and Fangfeng （Saposhnikoviae Radix） was the most frequently used herbal medicine. ③TCHMs used were mostly warm in nature， pungent， sweet and bitter in flavor， and most belonged to the spleen， heart， liver and lung meridians. ④According to analysis results of the medication rules， there were 13 combination patterns out of 11 TCHMs， which were listed as below： Chuanxiong （Chuanxiong Rhizoma） – Fangfeng （Saposhnikoviae Radix）， Gancao （Glycyrrhizae Radix et Rhizoma） – Fangfeng （Saposhnikoviae Radix）， Fangfeng （Saposhnikoviae Radix） – Duhuo （Angelicae Pubescentis Radix）， Fangfeng （Saposhnikoviae Radix） – Xixin （Asari Radix et Rhizoma）， Fangfeng （Saposhnikoviae Radix） – Fuzi （Aconiti Lateralis Radix Praeparata）， Chuanxiong （Chuanxiong Rhizoma） – Gancao （Glycyrrhizae Radix et Rhizoma）， Renshen （Ginseng Radix et Rhizoma） – Fushen （Poria cum Radix Pini）， Renshen （Ginseng Radix et Rhizoma） – Fangfeng （Saposhnikoviae Radix）， Renshen （Ginseng Radix et Rhizoma） – Fuling （Poria）， Shengjiang （Zingiberis Rhizoma Recens） – Fangfeng （Saposhnikoviae Radix）， Gancao （Glycyrrhizae Radix et Rhizoma） – Fuling （Poria）， Baishao （Paeoniae Radix Alba） – Fangfeng （Saposhnikoviae Radix）， and Chuanxiong （Chuanxiong Rhizoma） – Gancao （Glycyrrhizae Radix et Rhizoma） – Fangfeng （Saposhnikoviae Radix）. ⑤Based on the association rules analysis， 4 commonly used TCHMs combination patterns were obtained， including 4 TCHMS， i.e.， Fangfeng （Saposhnikoviae Radix）， Chuanxiong （Chuanxiong Rhizoma）， Duhuo （Angelicae Pubescentis Radix） and Gancao （Glycyrrhizae Radix et Rhizoma）. ⑥The cluster analysis showed that there were 4 core clusters which could potentially develop into 2 new formulas， i.e.， Chuanxiong （Chuanxiong Rhizoma） – Gancao （Glycyrrhizae Radix et Rhizoma） – Bohe （Menthae Haplocalycis Herba） – Duhuo （Angelicae Pubescentis Radix）， and Zhusha （Cinnabaris） – Gancao （Glycyrrhizae Radix et Rhizoma） – Bohe （Menthae Haplocalycis Herba） – Yuanzhi （Polygalae Radix）.,Conclusions,2,The prescriptions recorded in ,Puji Fang, for treating stroke mainly contain TCHMs for dispelling wind and dredging collaterals， invigorating qi and nourishing blood， and the representative TCHMs are Fangfeng （Saposhnikoviae Radix）， Duhuo （Angelicae Pubescentis Radix）， Xixin （Asari Radix et Rhizoma）， Shengjiang （Zingiberis Rhizoma Recens）， Fuzi （Aconiti Lateralis Radix Praeparata）， Chuanxiong （Chuanxiong Rhizoma）， Baishao （Paeoniae Radix Alba）， Gancao （Glycyrrhizae Radix et Rhizoma）， Renshen （Ginseng Radix et Rhizoma）， Fushen （Poria cum Radix Pini） and Fuling （Poria）. The new prescriptions developed based on the aforementioned basic prescription will provide reference to the follow-up study of stroke medication.