SUN Yanting,LI Yue,CHEN Yi,et al.Data mining⁃based research on Professor Lu Jingen’s prescription regularity in treating functional constipation[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(11):21-28.
SUN Yanting,LI Yue,CHEN Yi,et al.Data mining⁃based research on Professor Lu Jingen’s prescription regularity in treating functional constipation[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(11):21-28. DOI: 10.16305/j.1007-1334.2022.2203029.
Data mining⁃based research on Professor Lu Jingen’s prescription regularity in treating functional constipation
Objective,2,To use data mining methods to analyze Professor Lu Jingen’s medication experience and prescription pattern of traditional Chinese medicine (TCM) in treating functional constipation and summarize treatment principles.,Methods,2,The cases of functional constipation treated by Professor Lu Jingen in Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine from January 2018 to January 2021 were collected. The prescription information was extracted with Microsoft Excel software, and data mining was performed with R language data analysis platform to analyze the use frequency, association rules and clustering of traditional Chinese herbal medicines (TCHMs), and the correlation analysis was also performed.,Results,2,①A total of 261 TCM prescriptions were included, involving 129 TCHMs with a total frequency of 4,748 times. Fourteen TCHMs were used over 200 times, and TCHMs used more than 30 times were mainly categorized into deficiency-tonifying medicines, heat-clearing medicines, blood-activating and stasis-removing medicines, phlegm-resolving medicines, bowel-moistening medicines and qi-promoting medicines. ②Based on association rules and clustering analysis, two basic formulas were obtained, i.e., formula No.1 was composed of Huangqi (Astragali Radix), Baizhu (Atractylodis Macrocephalae Rhizoma), Xuanshen (Scophulariae Radix), Dihuang (Rehmanniae Radix), Maidong (Ophiopogonis Radix), Nanshashen (Adenophorae Radix) and Beishashen (Glehniae Radix), and formula No. 2 was composed of Danggui (Angelicae Sinensis Radix), Zhishi (Aurantii Fructus Immaturus), Danshen (Salviae Miltiorrhizae Radix et Rhizoma), Gualou (Trichosanthis Fructus), Huomaren (Cannabis Fructus), Laifuzi (Raphani Semen), Jiegeng (Platycodonis Radix) and Gancao (Glycyrrhizae Radix et Rhizoma); Two couplet medicines were obtained, i.e., Kuxingren (Armeniacae Semen Amarum) – Yuliren (Pruni Semen), and Honghua (Carthami Flos) – Taoren (Persicae Semen); And two combinations of medicines were obtained, i.e., Baihe (Lilii Bulbus) – Zhimu (Anemarrhenae Rhizoma) – Meiguihua (Rosae Rugosae Flos) – Shichangpu (Acori Tatarinowii Rhizoma), and Dazao (Jujubae Fructus) – Huaixiaomai (Triticum aestivum L.) – Zhigancao (Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle) – Lingzhi (Ganoderma) – Taizishen (Pseudostellariae Radix). ③The correlation analysis showed that the highly correlated couplet medicines were as follows: Honghua (Carthami Flos) – Taoren (Persicae Semen), Nanshashen (Adenophorae Radix) – Beishashen (Glehniae Radix), Baihe (Lilii Bulbus) – Zhimu (Anemarrhenae Rhizoma), Dazao (Jujubae Fructus) – Huaixiaomai (Triticum aestivum L.), and Meiguihua (Rosae Rugosae Flos) – Shichangpu (Acori Tatarinowii Rhizoma).,Conclusions,2,When treating functional constipation, Professor Lu Jingen takes invigorating qi and nourishing yin, dispersing lung and resolving turbidity as the general principles flexibly, chooses the methods of moving qi, activating blood, moistening bowels and calming mind, modifies individual prescription on the basis of “Yiqi Kaimi Formula” in clinical practice, and focuses on the use of TCHMs with the effects of supplementing qi, nourishing yin and invigorating spleen. Professor Lu’s clinical experience can provide ideas for clinical diagnosis and treatment of functional constipation.
关键词
功能性便秘中医药疗法名医经验数据挖掘用药规律
Keywords
functional constipationtraditional Chinese medicine therapyfamous doctor’s experiencedata miningmedication pattern
references
AZIZ I, WHITEHEAD W E, PALSSON O S, et al. An approach to the diagnosis and management of Rome Ⅳ functional disorders of chronic constipation[J]. Expert Rev Gastroenterol Hepatol, 2020, 14(1): 39-46.
VRIESMAN M H, KOPPEN I J N, CAMILLERI M, et al. Management of functional constipation in children and adults[J]. Nat Rev Gastroenterol Hepatol, 2020, 17(1): 21-39.
LONG Y, HUANG Z, DENG Y, et al. Prevalence and risk factors for functional bowel disorders in South China: a population based study using the Rome Ⅲ criteria[J]. Neurogastroenterol Motil, 2017, 29(1): e12897.
HUANG Y, TAN S Y, PARIKH P, et al. Prevalence of functional gastrointestinal disorders in infants and young children in China[J]. BMC Pediatr, 2021, 21(1): 131.
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