Objective,2,To investigate the clinical effect of Jiawei Mojie Tablets on primary dysmenorrhea of qi stagnation and blood stasis syndrome.,Methods,2,Seventy-three cases of primary dysmenorrhea of qi stagnation and blood stasis syndrome were randomly divided into a treatment group （,n,=35） and a control group （,n,=38）. The control group was administered with ibuprofen， while the treatment group was administered with Jiawei Mojie Tablets. The duration of treatment for both groups was 3 menstrual cycles. We observed the clinical efficacy， and compared the changes of pain visual analogue scale （VAS） scores， traditional Chinese medicine （TCM） symptom scores， the serum levels of inflammatory factors and β-endorphin， the Zung Self-Rating Anxiety Scale （SAS） scores and the Zung Self-Rating Depression Scale （SDS） scores before and after intervention.,Results,2,①During the trial， there were 3 drop-out cases in the treatment group and 4 drop-out cases in the control group， and 32 cases in the treatment group and 34 cases in the control group finally completed the trial. ②The total effective rate was 78.12% in the treatment group and 55.88% in the control group. The clinical efficacy of the treatment group was better than that of the control group （,P,<,0.05）. ③After treatment， the pain VAS scores decreased in both groups （,P,<,0.05）； The pain VAS scores in the treatment group were lower than those in the control group （,P,<,0.05）. ④After treatment， the sub-dimension scores of abdominal pain， menstrual blood clots， breast distension and pain， anal pendant expansion and total TCM symptom scores decreased in the treatment group （,P,<,0.05）， and the sub-dimension scores of abdominal pain and total TCM symptom scores decreased in the control group （,P,<,0.05）； After treatment， the sub-dimension scores of abdominal pain， menstrual blood clots， breast distension and pain， anal pendant expansion and total TCM symptom scores in the treatment group were lower than those in the control group （,P,<,0.05）. ⑤After treatment， the serum level of interleukin-6 （IL-6） decreased （,P,<,0.05） and the serum levels of interleukin-10 （IL-10） and β-endorphin increased （,P,<,0.05） in the treatment group，the serum levels of β-endorphin increased （,P,<,0.05） in the control group. After treatment， the differences in serum levels of IL-6， IL-10 and β-endorphin between the two groups were not statistically significant （,P,>,0.05）. ⑥After treatment， SDS scores decreased in the treatment group （,P,<,0.05）， but SAS and SDS scores did not change significantly in the control group （,P,>,0.05）. After treatment， SDS scores in the treatment group were lower than those in the control group （,P,<,0.05）.,Conclusions,2,Jiawei Mojie Tablets can effectively alleviate the clinical symptoms and improve the depressed emotional state of patients with primary dysmenorrhea of qi stagnation and blood stasis syndrome. The mechanisms involved may be that Jiawei Mojie Tablets can lower IL-6 level， raise IL-10 level， reduce inflammation， and promote the secretion of endogenous opioid analgesic substance β-endorphin， which in turn lowers pain threshold.