The clinical experience of Professor Xue Xiaohong in treating acne mastoid carbuncle （AMC） with the internal administration of traditional Chinese herbal medicines （TCHMs） based on the method of warming yang and dredging collaterals and local minimally invasive surgery is introduced in this article. In the process of diagnosis and treatment， Prof. Xue emphasizes yin-yang based syndrome differentiation and the integration of internal and external treatment. As to the pathogenesis of acne mastoid carbuncle， yang deficiency is the root and phlegm coagulation is the tip. The long-term phlegm accumulation transforms into heat， presenting a syndrome of intermingling of cold and heat. As to the internal treatment， Xue focuses on warming-eliminating， warming-dredging and warming-invigorating； As to the external treatment， Xue emphasizes the importance of timing， advising to stop treatment once the disease in controlled. One proved case is presented.