Objective,2,To establish UPLC fingerprint and content determination methods of Codonopsis Radix dispensing granules （CRDG） and honey bran frying Codonopsis Radix dispensing granules （HBFCRDG），and to provide a comprehensive evaluation of the quality of CRDG and HBFCRDG.,Methods,2,UPLC analysis was performed on a Waters ACQUITY UPLC HSS T3 column （2.1 mm×100 mm，1.8 μm），with a mobile phase consisting of acetonitrile （A） - 0.1% formic acid （B） at the flow rate of 0.3 mL·min,-1,. The column temperature was controlled at 30 ℃ and the detection wavelength was set at 268 nm. The injection volume was 3 μL.,Results,2,UPLC fingerprint and content determination methods of HBFCRDG were established. Lobetyolin displayed ideal linearity within the range of 2.4-100.0 mg·L,-1, （,R,2,=0.999 7）. The recoveries of lobetyolin in three levels of 50%，100% and 150% were 97.72%， 96.23%， 98.60% respectively，and the total average recovery was 97.52% with ,RSD, of 1.76%. The ,RSD, values of precision，repeatability and stability were all less than 3%. Nine common peaks were designated in fingerprint and peaks of lobetyolin，tangshenoside Ⅰ，lobetyolinin and lobetyol were confirmed by standard references. The content of lobetyolin in 28 batches of CRDG and HBFCRDG was between 0.06-0.39 mg·g,-1,. According to the results of PCA and PLS-DA，HBFCRDG can be distinguished from CRDG obviously. What’s more，it showed that there were differences in samples of CRDG from different manufacturers.,Conclusion,2,The method has the advantages of simple operation， high detection efficiency and strong specificity， and can be used for the quality evaluation of CRDG and HBFCRDG.