Objective,2,To study and analyze the medication rule of soothing the liver and clearing heat in the treatment of comedomastitis by data mining technology.,Methods,2,Medical records and prescriptions of the patients with comedomastitis（syndrome of heat stagnation in liver meridian） were collected in Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2019 to December 2021， and data mining analysis（BK algorithm， complex system entropy network） was performed using TCMNPAS， a TCM network pharmacology analysis system.,Results,2,①A total of 28 530 prescriptions were analyzed， involving 526 traditional Chinese herbal medicines， with a cumulative frequency of 416 463 times. ②There were 24 traditional Chinese herbal medicines with a frequency of more than 20%， and 9 traditional Chinese herbal medicines with a frequency of more than 10 000 （>35%） including Chinese herbal medicines such as （Taraxaci Herba， Bupleuri Radix， Gleditsiae Spina， raw Crataegi Fructus， Angelicae Sinensis Radix， Sinapis Semen， Curcumae Rhizoma， Scutellariae Radix， Salviae Miltiorrhizae Radix Et Rhizoma）. ③The top 30 traditional Chinese medicines were mainly Taraxaci Herba， Bupleuri Radix， Gleditsiae Spina， and so on. The top 30 core drug pairs of correlation value were Atractylodis Macrocephalae Rhizoma -Poria， Scutellariae Radix - Bupleuri Radix， Semiaquilegiae Radix - Smilacis Glabrae Rhizoma， and so on. ④After analysis， four groups of potential “core prescriptions” were found， among which the one with the highest confidence was Gleditsiae Spina， Scutellariae Radix， Taraxaci Herba， Angelicae Sinensis Radix， Bupleuri Radix， Curcumae Rhizoma， Sinapis Semen， Fritillariae Thunbergii Bulbus， Glycyrrhizae Radix Et Rhizoma and Lonicerae Japonicae Flos.,Conclusions,2,The method of soothing the liver and clearing heat is one of the classic internal treatment rules of TCM for comedomastitis， which often includs the Chinese herbal medicines such as Bupleuri Radix， Citri Reticulatae Pericarpium， Curcumae Radix， Taraxaci Herba， Scutellariae Radix， Oldenlandia， Glycyrrhizae Radix Et Rhizoma， Prunellae Spica，Lonice Raejaponicae Caulis and Smilacis Glabrae Rhizoma and so on. According to the patient’s condition， it can be combined with Chinese herbal medicines such as Angelicae Sinensis Radix， Curcumae Rhizoma， Salviae Miltiorrhizae Radix Et Rhizoma for activating blood and resolving stasis， Sinapis Semen， Cervi Cornu， Cinnamomi Cortex and Zingiberis Rhizoma Praeparatum for warming yang to dissipate bind， Fritillariae Thunbergii Bulbus， Atractylodis Macrocephalae Rhizoma， Citri Reticulatae Pericarpium and Pinelliae Rhizoma for resolving phlegm and dissipating bind， and Gleditsiae Spina， Astragali Radix for subduing swelling and expelling toxin on the basis of the internal treatment principle of soothing the liver and clearing heat.