A model of six meridians system containing three yin meridians and three yang meridians is constructed based on, Huangdi Neijing, （,The Yellow Emperor’s Inner Canon,）. The model contains the traditional Chinese medicine （TCM） concepts of yin and yang， exterior and interior， internal organs， meridians and collaterals， three yin and three yang， twelve divisions and sequence， and these concepts can be mutually corroborated and interconnected in this system. The model’s explanation has defused controversies over the nature of the six meridians in history， reflects the holistic view of the six meridians system with three yin and three yang， and corresponds with “theory of synthesized concepts”.