Objective,2,To investigate the clinical efficacy of traditional Chinese medicine （TCM） medicated diet Huangqi Zhuti Decoction （Astragalus pork trotter soup） on severe diabetic foot gangrene complicated with severe hypoproteinemia.,Methods,2,Eighty-seven patients with severe diabetic foot gangrene complicated with severe hypoproteinemia were randomly divided into a treatment group （,n,=44） and a control group （,n,=43）. Both groups were given the conventional treatment and a diabetes diet. The treatment group was additionally administered with Huangqi Zhuti Decoction， while the control group was given compound amino acid capsules. The treatment lasted 8 weeks. The clinical efficacy and wound healing were observed， and the changes of serum nutritional indexes， the levels of major and minor elements， peri-wound skin temperature， transcutaneous oxygen tension （TcPO2）， nerve conduction velocity （CV） and amplitude （Amp） were compared， and the safety evaluation was conducted.,Results,2,①During the trial， there were 2 drop-out cases in the treatment group and 1 drop-out case in the control group. Finally， 84 cases completed the experiment， with 42 cases in each group. ②The total effective rate of the treatment group was 90.48% and that of the control group was 71.43%. The treatment group had better clinical efficacy than the control group （,P,<,0.05）. ③According to the intra-group comparison before and after treatment， the wound area of the two groups decreased after treatment （,P,<,0.05）； After treatment， the wound area of the treatment group was smaller than that of the control group （,P,<,0.05）. ④With the prolongation of treatment time， the serum levels of nutritional indexes （albumin， prealbumin and hemoglobin） of the two groups were improved in different degrees （,P,<,0.01， ,P,<,0.05）， and the treatment group had better improvement than the control group （,P,<,0.01， ,P,<,0.05）. ⑤During the trail， the contents of Ca， Mg， Zn and Fe in serum of control group had no significant change （,P,>,0.05）. In the treatment group， compared with those before treatment， the contents of Mg and Fe in serum increased after 4 weeks of treatment （,P,<,0.05） and the contents of Mg， Zn and Fe in serum increased significantly after 8 weeks of treatment （,P,<,0.01）； the serum contents of Mg， Zn and Fe in the treatment group after 8 weeks of treatment were higher than those after 4 weeks of treatment （,P,<,0.01）. There was no significant difference in serum contents of Ca， Mg， Zn and Fe between the two groups after 4 weeks of treatment （,P,>,0.05）； After 8 weeks of treatment， the serum contents of Mg， Zn and Fe in the treatment group were higher than those in the control group （,P,<,0.01）. ⑥During the trial， there was no significant change in peri-wound skin temperature and transcutaneous oxygen tension in both groups （,P,>,0.05）； According to the inter-group comparisons at each observation point-in-time， there was no significant difference in peri-wound skin temperature and transcutaneous oxygen tension between the two groups （,P,>,0.05）. ⑦During the trail， the values of CV and Amp in the control group did not change significantly （,P,>,0.05）； With the prolongation of treatment time， the values of CV and Amp in the treatment group increased gradually （,P,<,0.01， ,P,<,0.05）. After 8 weeks of treatment， the values of CV and Amp in the treatment group were higher than those in the control group （,P,<,0.01）. ⑧There was no obvious adverse reaction in cases of the two groups.,Conclusion,2,TCM medicated diet Huangqi Zhuti Decoction has achieved satisfactory therapeutic effect on severe diabetic foot gangrene complicated with severe hypoproteinemia， which can significantly improve the nutritional status and neurological function of patients， increase the levels of major and minor elements， and promote wound healing without significant adverse reactions.