Research progress on Chinese medicine in prevention and treatment of diabetic nephropathy by interfering with NF⁃κB related signaling pathways

Jubin ZHANG; Chengyu PIAO; Tingting LIU; Xu WANG; Jing LIU; Xiuhong WU

doi:10.16305/j.1007-1334.2022.2111043

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Research progress on Chinese medicine in prevention and treatment of diabetic nephropathy by interfering with NF⁃κB related signaling pathways

更新时间：2022-07-13

- Research progress on Chinese medicine in prevention and treatment of diabetic nephropathy by interfering with NF⁃κB related signaling pathways
- Shanghai Journal of Traditional Chinese Medicine Vol. 56, Issue 5, Pages: 98-101(2022)
- 作者机构：
  
  1.黑龙江中医药大学药学院（黑龙江哈尔滨 150000）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2022.2111043
  CLC：
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张具斌,朴成玉,刘婷婷等.中药调控NF⁃κB相关信号通路防治糖尿病肾病的研究进展[J].上海中医药杂志,2022,56(05):98-101.

ZHANG Jubin,PIAO Chengyu,LIU Tingting,et al.Research progress on Chinese medicine in prevention and treatment of diabetic nephropathy by interfering with NF⁃κB related signaling pathways[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(05):98-101.
张具斌,朴成玉,刘婷婷等.中药调控NF⁃κB相关信号通路防治糖尿病肾病的研究进展[J].上海中医药杂志,2022,56(05):98-101. DOI： 10.16305/j.1007-1334.2022.2111043.

ZHANG Jubin,PIAO Chengyu,LIU Tingting,et al.Research progress on Chinese medicine in prevention and treatment of diabetic nephropathy by interfering with NF⁃κB related signaling pathways[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(05):98-101. DOI： 10.16305/j.1007-1334.2022.2111043.

摘要

综述中药调控核因子-κB（NF-κB）相关信号通路防治糖尿病肾病（DN）的研究进展。研究表明，DN的发生伴有NF-κB相关信号通路的异常活化，中药单体（毛蕊异黄酮、小檗碱、雷公藤红素等）及中药复方（芪丹地黄汤、黄芪汤、益肾胶囊等）可通过靶向调控NF-κB相关信号通路有效防治DN。

Abstract

This paper reviewed the research progress on Chinese medicine in the prevention and treatment of diabetic nephropathy （DN）by interfering with nuclear factor-kappa B （NF-κB） related signaling pathways. Studies had been confirmed that DN was accompanied with abnormal activation of NF-κB related signaling pathways. Chinese medicine monomer （calycosin， berberine， tripterine， etc.） and Chinese medicine compound prescriptions（Qidan Dihuang Decoction， Huangqi Decoction， Yishen Capsule， etc.） could effectively prevent DN by interfering with NF-κB related signaling pathways.

关键词

核因子-κB信号通路糖尿病肾病中药综述

Keywords

NF-κB signaling pathwaydiabetic nephropathytraditional Chinese herbal medicinereview

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