Clinical study of therapy of treating⁃winter⁃diseases⁃in⁃summer combined with doxazosin mesylate tablets in treating benign prostatic hyperplasia

Libin YANG; Yuhui ZHAO; Chunlei CHEN; Chao YU; Pimolsettapun JITTIKORN; Qianyuan FANG; Shijie LIANG; Zhihang ZHANG; Youkang ZHAO; Chenglin XU

doi:10.16305/j.1007-1334.2022.2111010

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Clinical study of therapy of treating⁃winter⁃diseases⁃in⁃summer combined with doxazosin mesylate tablets in treating benign prostatic hyperplasia

更新时间：2022-07-13

- Clinical study of therapy of treating⁃winter⁃diseases⁃in⁃summer combined with doxazosin mesylate tablets in treating benign prostatic hyperplasia
- Shanghai Journal of Traditional Chinese Medicine Vol. 56, Issue 6, Pages: 46-49(2022)
- 作者机构：
  
  1.上海中医药大学附属龙华医院泌尿外科（上海 200032）
  2.上海中医药大学附属市中医医院泌尿外科（上海 200071）
  3.上海市名中医周智恒泌尿男科工作室（上海 200032）
  4.泰国华侨中医院泌尿男科（泰国曼谷 10100）
  5.上海市浦东新区光明中医医院泌尿外科（上海 201300）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2022.2111010
  CLC：
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杨礼斌,赵玉辉,陈春雷等.冬病夏治疗法联合甲磺酸多沙唑嗪片治疗良性前列腺增生症的临床研究[J].上海中医药杂志,2022,56(06):46-49.

YANG Libin,ZHAO Yuhui,CHEN Chunlei,et al.Clinical study of therapy of treating⁃winter⁃diseases⁃in⁃summer combined with doxazosin mesylate tablets in treating benign prostatic hyperplasia[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(06):46-49.
杨礼斌,赵玉辉,陈春雷等.冬病夏治疗法联合甲磺酸多沙唑嗪片治疗良性前列腺增生症的临床研究[J].上海中医药杂志,2022,56(06):46-49. DOI： 10.16305/j.1007-1334.2022.2111010.

YANG Libin,ZHAO Yuhui,CHEN Chunlei,et al.Clinical study of therapy of treating⁃winter⁃diseases⁃in⁃summer combined with doxazosin mesylate tablets in treating benign prostatic hyperplasia[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(06):46-49. DOI： 10.16305/j.1007-1334.2022.2111010.

摘要

目的,2,观察冬病夏治疗法联合甲磺酸多沙唑嗪片治疗良性前列腺增生症（BPH）的临床疗效。,方法,2,将108例BPH患者随机分为治疗组和对照组，每组54例。对照组口服甲磺酸多沙唑嗪片，治疗组采用冬病夏治疗法（三伏天行艾灸加穴位贴敷）联合甲磺酸多沙唑嗪片治疗，疗程均为2018年、2019年、2020年的三伏期间（约6周的夏令节气内）。观察治疗前后两组国际前列腺症状评分（IPSS）、生活质量评分（QOL）、中医证候积分、最大尿流率（Q,max,）及前列腺体积（PV）的变化情况，并在当年冬季随访患者IPSS、QOL、中医证候积分情况。,结果,2,①最终完成试验者98例，其中治疗组50例，对照组48例。②治疗组总有效率为72.00%，对照组总有效率为56.35%；两组临床疗效比较，治疗组优于对照组（,P,<,0.05）。③治疗后，两组IPSS、QOL、中医证候积分、Q,max,均较治疗前明显改善（,P,<,0.05）；治疗组在改善QOL、中医证候积分、Q,max,方面优于对照组（,P,<,0.05）。④随访时组内比较，两组IPSS、QOL、中医证候积分较治疗前明显改善（,P,<,0.05），QOL、中医证候积分均较治疗后明显改善（,P,<,0.05）；治疗组随访时IPSS与治疗后比较差异无统计学意义（,P,>,0.05），对照组随访IPSS与治疗后比较差异有统计学意义（,P,<,0.05）；随访时组间比较，治疗组IPSS、QOL、中医证候积分改善均优于对照组（,P,<,0.05）。⑤两组不良反应发生率比较，差异无统计学意义（,P,>,0.05）。,结论,2,冬病夏治法联合甲磺酸多沙唑嗪片治疗BPH能提高临床疗效，减少IPSS，改善排尿症状，提高患者生活质量，疗效可维持且安全。

Abstract

Objective,2,To observe the clinical efficacy of treating-winter-diseases-in -summer combined with doxazosin mesylate tablets in the treatment of benign prostatic hyperplasia（BPH）.,Methods,2,A total of 108 patients with BPH were randomly divided into two groups， the treatment group and the control group， 54 cases in each group. The control group received doxazosin mesylate tablets， while the treatment group received doxazosin mesylate tablets combined with treating-winter-diseases-in-summer（moxibustion and acupoint application in the dog days）. The treatment course of both groups was in the dog days（about 6 weeks in summer）of 2018， 2019 and 2020 . The changes of international prostate symptom score （IPSS）， quality of life score （QOL）， TCM syndrome score， maximum urine flow rate （Q,max,）， and prostate volume （PV） in two groups were observed before and after treatment. IPSS， QOL， and TCM syndrome scores were followed up in the winter of the same year.,Results,2,①A total of 98 patients completed the treatment， including 50 cases in the treatment group and 48 cases in the control group. ②The total effective rate was 72.00% in the treatment group and 56.35% in the control group. The clinical efficacy of the treatment group was better than that of the control group （,P,<,0.05）. ③After treatment， IPSS， QOL， TCM syndrome score， and Q,max, in two groups were significantly improved compared with before treatment （,P,<,0.05）. The treatment group was better than the control group in improving QOL， TCM syndrome score， and Q,max, （,P,<,0.05）. ④During the period of follow up， IPSS， QOL， and TCM syndrome scores of the two groups were significantly improved compared with those before treatment （,P,<,0.05）， QOL and TCM syndrome scores were significantly improved compared with those after treatment （,P,<,0.05）； There was no significant difference in IPSS between follow-up and after treatment in the treatment group（,P,>,0.05）， while there was a significant difference in IPSS between follow-up and after treatment in the control group （,P,<,0.05）； The improvement of IPSS， QOL， and TCM syndrome score in the treatment group was better than that in the control group （,P,<,0.05）. ⑤There was no significant difference in the incidence of adverse reactions between the two groups （,P,>,0.05）.,Conclusions,2,Treating-winter-diseases-in -summer combined with doxazosin mesylate tablets in the treatment of BPH can improve clinical efficacy， reduce IPSS， improve the urination symptoms， and improve the quality of life of patients. The treatment is safe and lasting for a while.

关键词

良性前列腺增生症冬病夏治甲磺酸多沙唑嗪片临床试验

Keywords

benign prostatic hyperplasiatreating-winter-diseases-in -summerdoxazosin mesylateclinical trial

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