Short⁃term efficacy of Kangliu Jiandu Recipe in patients with non⁃small cell lung cancer undergoing chemotherapy and its effect on serum VEGF level

Yuejiao CAI; Haibin DENG; Hang ZHOU; Zhenye XU

doi:10.16305/j.1007-1334.2022.2110051

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Short⁃term efficacy of Kangliu Jiandu Recipe in patients with non⁃small cell lung cancer undergoing chemotherapy and its effect on serum VEGF level

更新时间：2022-07-10

- Short⁃term efficacy of Kangliu Jiandu Recipe in patients with non⁃small cell lung cancer undergoing chemotherapy and its effect on serum VEGF level
- Shanghai Journal of Traditional Chinese Medicine Vol. 56, Issue 2, Pages: 34-37(2022)
- 作者机构：
  
  1.上海中医药大学附属龙华医院肿瘤科（上海 200032）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2022.2110051
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蔡玥娇,邓海滨,周航等.抗瘤减毒方对非小细胞肺癌化疗患者近期疗效及血清VEGF水平的影响[J].上海中医药杂志,2022,56(02):34-37.

CAI Yuejiao,DENG Haibin,ZHOU Hang,et al.Short⁃term efficacy of Kangliu Jiandu Recipe in patients with non⁃small cell lung cancer undergoing chemotherapy and its effect on serum VEGF level[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(02):34-37.
蔡玥娇,邓海滨,周航等.抗瘤减毒方对非小细胞肺癌化疗患者近期疗效及血清VEGF水平的影响[J].上海中医药杂志,2022,56(02):34-37. DOI： 10.16305/j.1007-1334.2022.2110051.

CAI Yuejiao,DENG Haibin,ZHOU Hang,et al.Short⁃term efficacy of Kangliu Jiandu Recipe in patients with non⁃small cell lung cancer undergoing chemotherapy and its effect on serum VEGF level[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(02):34-37. DOI： 10.16305/j.1007-1334.2022.2110051.

摘要

目的,2,观察抗瘤减毒方对非小细胞肺癌化疗患者近期疗效及血清血管内皮生长因子（VEGF）水平的影响。,方法,2,将70例非小胞肺癌患者随机分为治疗组、对照组，每组35例。对照组予单纯化疗（TP方案），治疗组在化疗的基础上加用抗瘤减毒方，28 d为1个疗程，共治疗2个疗程。观察两组近期疗效，比较血清VEGF水平的变化情况，以及两组治疗方案对患者造血功能、肝肾功能、肠胃功能的影响。,结果,2,①试验过程中治疗组、对照组各脱落5例，最终完成试验者60例，治疗组、对照组各30例。②治疗组、对照组疾病控制率分别为93.33%、70.00%，治疗组近期疗效优于对照组（,P,<,0.05）。③治疗前后组内比较，治疗组血清VEGF水平下降、对照组血清VEGF水平升高（,P,<,0.05）；组间治疗后比较，血清VEGF水平差异无统计学意义（,P,>,0.05）。④治疗组恶心、呕吐、白细胞降低发生率低于对照组（,P,<,0.05）；两组肝肾功能相关不良反应发生率比较，差异无统计学意义（,P,>,0.05）。,结论,2,抗瘤减毒方能有效提高非小细胞肺癌化疗患者的近期疗效，降低血清VEGF水平，减轻化疗药物的毒副反应。

Abstract

Objective,2,To observe the short-term efficacy of Kangliu Jiandu Recipe on patients with non-small cell lung cancer （NSCLC） undergoing chemotherapy and its effect on serum vascular endothelial growth factor （VEGF） level.,Methods,2,Seventy patients with NSCLC were randomly divided into the treatment group and control group， 35 cases in each group. The control group was treated with simple chemotherapy （TP scheme）， and the treatment group was treated with Kangliu Jiandu Recipe on the basis of chemotherapy. Twenty eight days were taken as one course of treatment， and a total of two courses were performed. The short-term efficacy of the two groups were observed， the change of serum VEGF level was compared， and the effects of the two therapy schemes on hematopoietic function， liver and kidney function and gastrointestinal function were compared.,Results,2,①During the trial， 5 cases in the treatment group and 5 cases in the control group fell off， finally 60 cases completed the trial， including 30 cases in the treatment group and 30 cases in the control group. ②The disease control rates of the treatment group and the control group were 93.33% and 70.00% respectively. The short⁃term efficacy of the treatment group was better than that of the control group （,P,<,0.05）. ③Compared with that before treatment， the serum level of VEGF was decreased in the treatment group but increased in the control group （,P,<,0.05）. After treatment， there was no statistically significant difference in serum VEGF level between the two groups （,P,>,0.05）. ④The incidence rates of nausea， vomiting and leucopenia in the treatment group were lower than those in the control group （,P,<,0.05）. There was no statistically significant difference in the incidence of adverse reactions related to liver and kidney function between the two groups （,P,>,0.05）.,Conclusion,2,Kangliu Jiandu Recipe can effectively improve the efficacy of NSCLC patients undergoing chemotherapy， reduce the serum level of VEGF and alleviate the toxic and side reactions of chemotherapy drugs.

关键词

非小细胞肺癌抗瘤减毒方化疗血管内皮生长因子减毒增效临床试验

Keywords

non-small cell lung cancerKangliu Jiandu Recipechemotherapyvascular endothelial growth factorreducing toxicity and enhancing efficiencyclinical trial

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