Clinical observation on Xiaotan Tongluo Gel together with gabapentin and methylcobalamin in the treatment of postherpetic neuralgia

Jie ZHOU; Xuan LIU; Wei KONG; Yi QU; Pinkang WEI; Ci’an ZHANG

doi:10.16305/j.1007-1334.2022.2110020

您当前的位置：

首页 >

文章列表页 >

Clinical observation on Xiaotan Tongluo Gel together with gabapentin and methylcobalamin in the treatment of postherpetic neuralgia

更新时间：2022-07-10

- Clinical observation on Xiaotan Tongluo Gel together with gabapentin and methylcobalamin in the treatment of postherpetic neuralgia
- Shanghai Journal of Traditional Chinese Medicine Vol. 56, Issue 3, Pages: 90-92(2022)
- 作者机构：
  
  1.上海中医药大学附属第七人民医院皮肤科（上海 200137）
  2.海军军医大学附属长征医院中医科（上海　　　　200003）
  3.上海市浦东新区人民医院皮肤科（上海 201299）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2022.2110020
  CLC：
扫描看全文
周洁,刘煊,孔伟等.消痰通络凝胶联合加巴喷丁、甲钴胺治疗带状疱疹后神经痛的临床观察[J].上海中医药杂志,2022,56(03):90-92.

ZHOU Jie,LIU Xuan,KONG Wei,et al.Clinical observation on Xiaotan Tongluo Gel together with gabapentin and methylcobalamin in the treatment of postherpetic neuralgia[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(03):90-92.
周洁,刘煊,孔伟等.消痰通络凝胶联合加巴喷丁、甲钴胺治疗带状疱疹后神经痛的临床观察[J].上海中医药杂志,2022,56(03):90-92. DOI： 10.16305/j.1007-1334.2022.2110020.

ZHOU Jie,LIU Xuan,KONG Wei,et al.Clinical observation on Xiaotan Tongluo Gel together with gabapentin and methylcobalamin in the treatment of postherpetic neuralgia[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(03):90-92. DOI： 10.16305/j.1007-1334.2022.2110020.

摘要

目的,2,观察消痰通络凝胶联合加巴喷丁、甲钴胺治疗带状疱疹后神经痛（PHN）的临床疗效。,方法,2,将125例PHN患者随机分为治疗组（65例）和对照组（60例）。两组均给予加巴喷丁胶囊、甲钴胺片口服，在此基础上，治疗组加用消痰通络凝胶局部涂擦，对照组加用安慰剂凝胶，14 d为1个疗程，连续治疗2个疗程。观察临床疗效，比较疼痛视觉模拟评分（VAS）、匹茨堡睡眠质量指数量表（PSQI）评分、血清P物质（SP）水平的变化情况。,结果,2,①治疗14 d时，治疗组、对照组总有效率分别为70.77%、53.33%，治疗组临床疗效优于对照组（,P,<,0.05）；治疗后，治疗组、对照组总有效率分别为89.23%、70.00%，治疗组临床疗效优于对照组（,P,<,0.01）。②治疗14 d、治疗后与治疗前组内比较，两组VAS评分、PSQI评分、血清SP水平降低（,P,<,0.01）；治疗14 d、治疗后组间比较，治疗组VAS评分、PSQI评分、SP水平低于对照组（,P,<,0.05，,P,<,0.01）。,结论,2,与单纯采用加巴喷丁、甲钴胺相比，加用消痰通络凝胶治疗PHN疗效满意，能更好地改善疼痛症状，提高患者的生活质量。

Abstract

Objective,2,To investigate the clinical efficacy of Xiaotan Tongluo Gel combined with gabapentin capsules and methylcobalamin tablets in treating postherpetic neuralgia （PHN）.,Methods,2,Totally 125 patients with PHN were randomly divided into a treatment group （,n,=65） and a control group （,n,=60）. Both groups were administered with gabapentin capsules and mecobalamin tablets orally. Additionally， the treatment group was provided with Xiaotan Tongluo Gel for external application while the control group was provided with placebo gel. Both groups were treated continuously for 2 courses with 14 days in each course. The clinical efficacy was observed， and the changes of Visual Analogue Scale （VAS） score， Pittsburgh Sleep Quality Index （PSQI） score and serum substance P （SP） level were compared.,Results,2,①The total effective rate was 70.77% in the treatment group and 53.33% in the control group after 14 days of treatment， and the clinical efficacy of the treatment group was better than that of the control group （,P,<,0.05）. After 28 days of treatment， the total effective rate was 89.23% in the treatment group and 70.00% in the control group， and the clinical efficacy of the treatment group was better than that of the control group （,P,<,0.01）. ②The VAS score， PSQI score， and serum SP level decreased in both groups after 14 days and 28 days of treatment compared with those before treatment （,P,<,0.01）. The VAS score， PSQI score and SP level in the treatment group were lower than those in the control group after 14 days and 28 days of treatment， respectively （,P,<,0.05， ,P,<,0.01）.,Conclusion,2,Compared with the clinical efficacy of gabapentin capsules and methylcobalamin tablets， the application of Xiaotan Tongluo gel together with gabapentin and methylcobalamin has achieved more satisfactory results in the treatment of PHN， which could better alleviate pain and improve patients’ quality of life.

关键词

带状疱疹神经痛加巴喷丁甲钴胺消痰通络凝胶中医药疗法临床试验

Keywords

herpes zosterneuralgiagabapentinmethylcobalaminXiaotan Tongluo Geltraditional Chinese medicine therapyclinical trial

references

HADLEY G R， GAYLE J A， RIPOLL J， et al. Post-herpetic neuralgia： a Review［J］. Curr Pain Headache Rep， 2016， 20（3）： 17.

文体，王奇凡. 带状疱疹及带状疱疹后神经痛流行病学及经济负担研究进展［J］. 天津医药，2018， 46（5）： 552-556.

带状疱疹后神经痛诊疗共识编写专家组. 带状疱疹后神经痛诊疗中国专家共识［J］. 中国疼痛医学杂志，2016， 22（3）： 161-167.

李元文，王京军，孙占学，等. 从“络”探讨带状疱疹后遗神经痛的中医治疗［J］. 中医杂志，2019， 60（8）： 653-655.

徐晶钰，张璇，王晓炜，等. 消痰通络凝胶联合甲钴胺片治疗化疗诱导性周围神经病变临床研究［J］. 中国中医药信息杂志，2018， 25（7）： 11-15.

赵辨. 中国临床皮肤病学［M］. 南京：江苏科学技术出版社，2010： 396

曹卉娟，邢建民，刘建平. 视觉模拟评分法在症状类结局评价测量中的应用［J］. 中医杂志，2009， 50（7）： 600-602.

路桃影，李艳，夏萍，等. 匹兹堡睡眠质量指数的信度及效度分析［J］. 重庆医学，2014， 43（3）： 260-263.

国家药品监督管理局. 中药新药临床研究指导原则（试行）［M］. 北京：中国医药科技出版社，2002： 29-31.

BARON R ， BINDER A ， WASNER G. Neuropathic pain： diagnosis， pathophysiological mechanisms， and treatment［J］. Lancet Neurol， 2010， 9（8）： 807-819.

赵志奇. 带状疱疹痛：基础和临床概述［J］. 中国疼痛医学杂志，2014， 20（6）： 369-375.

申海燕，袁燕，孙灿林，等. 神经阻滞疗法治疗带状疱疹后神经痛的研究进展［J］. 中国疼痛医学杂志，2017， 23（1）： 59-63.

凌晓瑜，张慧君，卜林凌，等. 近5年中医药治疗带状疱疹神经痛概况［J］. 中医文献杂志，2018， 36（5）： 73-76.

中华中医药学会皮肤科分会. 蛇串疮中医诊疗指南（2014年修订版）［J］. 中医杂志，2015， 56（13）： 1163-1168.

徐莹莹，张毅. 中医内治带状疱疹后遗神经痛概况［J］. 湖南中医杂志，2013， 29（11）： 155-156.

彭海东，魏品康，俞珊. 消痰通络外用中药制剂对腰神经根性痛大鼠神经根功能和组织学的作用［J］. 中国临床康复，2006， 10（47）： 67-70， 229.

叶敏，孙大志，秦志丰，等. 消痰通络凝胶外用治疗癌性疼痛临床观察［J］. 中国中医药信息杂志，2010， 17（7）： 22-24.

王楠楠，付金霞，张贺男，等. 柴胡疏肝散联合加巴喷丁治疗PHN患者的疗效及对炎症指标、疼痛相关物质及神经相关因子的影响［J］. 中国医院药学杂志，2019， 39（24）： 2542-2546.

田浩，田永静，王兵，等. 刺血拔罐对带状疱疹后遗神经痛患者血清P物质的影响［J］. 中国针灸，2013， 33（8）： 678-681.

Views

200

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Experience in treating postherpetic neuralgia with collateral theory

Clinical study on the treatment of lower limb venous ulcer of qi deficiency and blood stasis syndrome with Modified Qilong Quyu Mixture plus external treatment and conditioning

Clinical study on application of Huoxue Huayu Decoction combined with methotrexate in treatment of rheumatoid arthritis

Clinical study on intervention of Fuzheng Hejie Recipe in children with asymptomatic infection of SARS⁃CoV⁃2 Omicron variant

Clinical observation on Buxu Qufeng Decoction combined with routine therapy in treatment of Ⅳ stage diabetic kidney disease

Related Author

No data

Related Institution

Department of Pain， Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

Department of Orthopedics and Traumatology， Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

Shi Qi Traditional Chinese Medicine Inheritance Studio

Shanghai University of Traditional Chinese Medicine

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

⁰