WANG Yingdi,HE Zhuqing,LI Xiaoqian,et al.Exploration on law of syndrome and treatment of congestive heart failure in ancient literatures based on multivariate data mining methods[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(11):13-20.
WANG Yingdi,HE Zhuqing,LI Xiaoqian,et al.Exploration on law of syndrome and treatment of congestive heart failure in ancient literatures based on multivariate data mining methods[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(11):13-20. DOI: 10.16305/j.1007-1334.2022.2108075.
Exploration on law of syndrome and treatment of congestive heart failure in ancient literatures based on multivariate data mining methods
Objective,2,To explore the law of traditional Chinese medicine syndrome and treatment for congestive heart failure (CHF) in ancient literatures based on the data mining methods.,Methods,2,The medical records conforming to CHF diagnosis in ancient literatures from the databases including Chinese Medical Code (the fifth edition), Chaoxing digital books, paper documents, etc were collected. The statistical analysis and data mining were carried out by R language and SPSS 25.0 software, and the analysis methods included frequency analysis, association analysis, co-occurrence analysis, factor analysis, cluster analysis, complex network analysis, etc.,Results,2,①The most common symptoms of CHF included asthma, cough, chest tightness, inability to lie down, shortness of breath, swollen feet and so on. The tongue image was mainly white coating and the pulse condition was mainly deep, thin and string pulse. The syndrome elements were mainly phlegm turbidity, fluid retention, yang deficiency, qi deficiency, yin deficiency and so on. ②The double-related symptoms mainly included asthma + cough, asthma + inability to lie down, asthma + shortness of breath, asthma + phlegm, asthma + swollen feet, inability to lie down + cough, asthma + chest tightness, etc, and the three associated symptoms were mainly asthma + inability to lie down + cough. ③Among disease nature elements, yang deficiency was most related to phlegm turbidity and fluid retention, qi deficiency was most related to phlegm turbidity, fluid retention and yin deficiency, and phlegm turbidity was most related to fluid retention and qi deficiency. Yang deficiency and fluid retention of disease nature elements were most related to lung, spleen and kidney of disease location elements. Phlegm turbidity and qi deficiency of disease nature elements were most related to heart, lung, spleen and kidney of disease location elements. Yin deficiency of disease nature elements was most related to heart of disease location elements. ④The core symptoms of yang deficiency and water flooding syndrome of CHF included swollen feet, cold limbs, ascites, swollen face, irritability, edema, spontaneous sweating, less urination, poor sleep, inability to lie down, and shortness of breath. The core symptoms of qi deficiency and phlegm turbidity syndrome included cough, phlegm, poor appetite, asthma, diarrhea, heartache, and poor sleep. The core symptoms of qi and yin deficiency syndrome included palpitations, coma, dizziness, constipation, fantod, less urination, weakness, poor sleep, and asthma, with soft pulse, rapid pulse, thin pulse, weak pulse, and so on according to the different degree of the disease. The core symptoms of qi deficiency and blood stasis syndrome included chest pain, chest tightness, heartache, poor appetite, asthma with moving, fatigue, shortness of breath, weakness, and less urination, with deep pulse, string pulse and weak pulse according to the different degree of the disease. ⑤The most commonly used Chinese medicines in the treatment of CHF included Proia, Aconiti Lateralis Radix Praeparata, Codonopsis Radix, Cinnamomi Cortex, Atractylodis Macrocephalae Rhizoma, Citri Reticulatae Pericarpium, Rehmanniae Radix Praeparata, Alismatis Rhizoma, etc. The main prescriptions included Jinkui Shenqi Pill, Jisheng Shenqi Pill, Tingli Dazao Xiefei Decoction, Zhenwu Decoction, Erchen Decoction, Gualou Xiebai Banxia Decoction, Sijunzi Decoction, Buzhong Yiqi Decoction, Tianwang Buxin Pill, etc.,Conclusion,2,Through the data mining on medical records in ancient literatures, it can be seen that, the syndrome and treatment of CHF have certain laws and the therapeutic methods are multiple, which can provide an ancient literature evidence for clinical treatment.
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