Objective,2,To observe the effect of Polygoni Multiflori Caulis （PMC） and PMC plus Astragali Radix （AR） on concanavalin A （ConA） induced immunological liver injury （ILI） in model mice.,Methods,2,Seventy healthy ICR mice （SPF grade） were randomly divided into normal group， model group， normal group plus high-dose or low-dose PMC， model group plus high-dose or low-dose PMC， model group plus high-dose PMC and AR， with 10 mice in each group. After 10 consecutive days of intragastric administration， ConA with 10 mg·kg,-1, injected intravenously was used to induce the ILI model at the last intragastric administration in all groups except the normal groups. 8 hours later， the mice were sacrificed and samples were collected. The pathological changes of liver were observed by HE staining. Liver function （ALT， AST， MDA， MAO， GST， DBIL， IBIL） and blood lipid （TC， TG， LDL-C） were detected by biochemical method.,Results,2,Compared with the normal group， liver weight， liver index， ALT， AST， MDA and MAO of the model group were increased （,P,<,0.05）， while TG and GST were decreased （,P,<,0.05）. Liver HE staining showed a large number of infiltrated inflammatory cells in the model group. After PMC given （high or low doses）， ALT， AST， MDA and MAO levels were increased significantly （,P,<,0.05）， while GST was decreased （,P,<,0.05）. Additionally， HE staining showed more inflammatory cell infiltration with partial necrosis of liver cells in the model group plus high-dose PMC. However， ILI mice administrated with combination of high-dose PMC and AR， the liver weight， liver index， ALT， AST， MDA and MAO were decreased （,P,<,0.05）， but GST was increased （,P,<,0.05）. Liver HE staining also showed less inflammatory cell infiltration and necrocytosis.,Conclusion,2,PMC can further destroy the liver function of ILI mice， while RA can produce certain protective effect.