Research progress on factors inducing activation of hair follicle stem cells during hair regeneration

Tingting ZUO; Meiling YAN; Ying ZHU; Yanhong SUN; Yi ZHOU

doi:10.16305/j.1007-1334.2022.2104060

您当前的位置：

首页 >

文章列表页 >

Research progress on factors inducing activation of hair follicle stem cells during hair regeneration

更新时间：2022-07-13

- Research progress on factors inducing activation of hair follicle stem cells during hair regeneration
- Shanghai Journal of Traditional Chinese Medicine Vol. 56, Issue 6, Pages: 100-105(2022)
- 作者机构：
  
  1.中国科学院上海应用物理研究所（上海 201800）
  2.中国科学院大学（北京 100049）
  3.中国科学院上海高等研究院（上海 201210）
  4.成都中医药大学（四川成都 610075）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2022.2104060
  CLC：
扫描看全文
左婷婷,闫美玲,诸颖等.毛发再生过程中诱导毛囊干细胞激活因素的研究进展[J].上海中医药杂志,2022,56(06):100-105.

ZUO Tingting,YAN Meiling,ZHU Ying,et al.Research progress on factors inducing activation of hair follicle stem cells during hair regeneration[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(06):100-105.
左婷婷,闫美玲,诸颖等.毛发再生过程中诱导毛囊干细胞激活因素的研究进展[J].上海中医药杂志,2022,56(06):100-105. DOI： 10.16305/j.1007-1334.2022.2104060.

ZUO Tingting,YAN Meiling,ZHU Ying,et al.Research progress on factors inducing activation of hair follicle stem cells during hair regeneration[J].Shanghai Journal of Traditional Chinese Medicine,2022,56(06):100-105. DOI： 10.16305/j.1007-1334.2022.2104060.

摘要

综述毛发再生过程中诱导毛囊干细胞激活因素的最新研究进展。新型药物、新型经皮给药方式及新的物理刺激方法可诱导毛囊干细胞激活，促进毛发生长。特别是纳米材料、纳米技术及中药复方思想的引入，微粒、微针新型经皮给药体系和基于中药成分的生物膜体系，以及机械牵拉、针灸、光电等物理刺激方式，为毛发生长调控的研究及病理性脱发的治疗提供了新思路。

Abstract

This paper summarized the latest progress in the activation methods of hair follicle stem cells in the process of hair regeneration. New drugs， new transdermal drug delivery methods and new physical stimulation methods can induce the activation of hair follicle stem cells and promote hair growth. In particular， the introduction of nanomaterials， nanotechnology and traditional Chinese medicine compounds， the new transdermal drug delivery system of nanoparticles and microneedles， the biofilm system based on traditional Chinese medicine components， and the physical stimulation methods such as mechanical traction， acupuncture， laser and electro-stimulation have provided new insights for the research on regulating hair growth and the treatment of pathological hair loss.

关键词

病理性脱发毛囊干细胞激活方式经皮给药针灸中药物理刺激综述

Keywords

pathological hair losshair follicle stem cellactivation methodtransdermal drug deliveryacupuncturetraditional Chinese herbal medicinephysical stimulationreview

references

JI J， HO B S， QIAN G， et al. Aging in hair follicle stem cells and niche microenvironment［J］. J Dermatol， 2017， 44（10）： 1097-1104.

崔晓，曾维惠，夏育民. 毛囊发育与周期性生长的调控信号研究进展［J］. 中国皮肤性病学杂志，2019， 33（9）： 1081-1084.

FLORES A， SCHELL J， KRALL A S， et al. Lactate dehydrogenase activity drives hair follicle stem cell activation［J］. Nat Cell Biol， 2017， 19（9）： 1017-1026.

XING L， DAI Z， JABBARI A， et al. Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition［J］. Nat Med， 2014， 20（9）： 1043-1049.

CHAI M， JIANG M， VERGNES L， et al. Stimulation of hair growth by small molecules that activate autophagy［J］. Cell Rep， 2019， 27（12）： 3413-3421.

WANG E H C， SALLEE B N， TEJEDA C I， et al. JAK inhibitors for treatment of alopecia areata［J］. J Invest Dermatol， 2018， 138（9）： 1911-1916.

DIVITO S J， KUPPER T S. Inhibiting Janus kinases to treat alopecia areata［J］. Nat Med， 2014， 20（9）： 989-990.

HAREL S， HIGGINS C A， CERISE J E， et al. Pharmacologic inhibition of JAK-STAT signaling promotes hair growth［J］. Sci Adv， 2015， 1（9）： e1500973.

WANG Y， WEN X， HAO D， et al. Insights into autophagy machinery in cells related to skin diseases and strategies for therapeutic modulation［J］. Biomed Pharmacother， 2019， 113： 108775.

MA S， SUN S， GENG L， et al. Caloric restriction reprograms the single-cell transcriptional landscape of rattus norvegicus aging［J］. Cell， 2020， 180（5）： 984-1001.

FORNI M F， PELOGGIA J， BRAGA T T， et al. Caloric restriction promotes structural and metabolic changes in the skin［J］. Cell Rep， 2017， 20（11）： 2678-2692.

HAYASHI A， MIKAMI Y， MIYAMOTO K， et al. Intestinal dysbiosis and biotin deprivation induce alopecia through overgrowth of lactobacillus murinus in mice［J］. Cell Rep， 2017， 20（7）： 1513-1524.

SON M J， JEONG J K， KWON Y， et al. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming［J］. Exp Mol Med， 2018， 50（12）： 1-15.

赵炳南，张志礼. 简明中医皮肤病学［M］. 北京：中国中医药出版社，2014： 231.

LEEM J， JUNG W， KIM Y， et al. Exploring the combination and modular characteristics of herbs for alopecia treatment in traditional Chinese medicine： an association rule mining and network analysis study［J］. BMC Complement Altern Med， 2018， 18（1）：204.

徐莲，吴岚，王雪，等. 黄芪、何首乌、女贞子、菟丝子混合提取物对体外培养毛囊生长的影响及药理作用研究［J］. 现代生物医学进展，2014， 14（22）： 4201-4204.

朱培成，侯志庄，张娴，等. 中药益发复方含药血清对毛囊干细胞增殖及K19、β1整合素mRNA表达的调控作用［J］. 中国中西医结合皮肤性病学杂志，2013， 12（6）： 356-358.

ZHANG B ， ZHANG R W， YIN X Q， et al. Inhibitory activities of some traditional Chinese herbs against testosterone 5α-reductase and effects of Cacumen platycladi on hair re-growth in testosterone-treated mice［J］. J Ethnopharmacol， 2016（177）： 1-9.

LUMACHI F， RONDINONE R. Use of cyproterone acetate， finasteride， and spironolactone to treat idiopathic hirsutism［J］. Fertil Steril， 2003， 79（4）： 942-946.

MESSENGER A G， RUNDEGREN J. Minoxidil： mechanisms of action on hair growth［J］. Br J Dermatol， 2004， 150（2）： 186-194.

CIOTTI S N， WEINER N. Follicular liposomal delivery systems［J］. J Liposome Res， 2002， 12（1-2）： 143-148.

MüNSTER U， NAKAMURA C， HABERLAND A， et al. RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia［J］. Pharmazie， 2005， 60（1）： 8-12.

AGARWAL R， KATARE O P， VYAS S P. The pilosebaceous unit： a pivotal route for topical drug delivery［J］. Methods Find Exp Clin Pharmacol， 2000， 22（2）： 129-133.

MATOS B N， REIS T A， GRATIERI T， et al. Chitosan nanoparticles for targeting and sustaining minoxidil sulphate delivery to hair follicles［J］. Int J Biol Macromol， 2015（75）： 225-229.

KIM H S， KWON H K， LEE D H， et al. Poly（γ-glutamic acid）/chitosan hydrogel nanoparticles for effective preservation and delivery of fermented herbal extract for enlarging hair bulb and enhancing hair growth［J］. Int J Nanomed， 2019（14）： 8409-8419.

ARORA A， PRAUSNITZ M R， MITRAGOTRI S. Micro-scale devices for transdermal drug delivery［J］. Int J Pharm， 2008， 364（2）： 227-236.

LEE Y B， EUN Y S， LEE J H， et al. Effects of topical application of growth factors followed by microneedle therapy in women with female pattern hair loss： a pilot study［J］. J Dermatol， 2013， 40（1）： 81-83.

YANG G， CHEN Q， WEN D， et al. A therapeutic microneedle patch made from hair-derived keratin for promoting hair regrowth［J］. ACS Nano， 2019， 13（4）： 4354-4360.

ZHANG Z， DAI Q， ZHANG Y， et al. Design of a multifunctional biomaterial inspired by ancient Chinese medicine for hair regeneration in burned skin［J］. ACS Appl Mater Interfaces， 2020， 12（11）： 12489-12499.

张泰. 芳香性中药成分透皮吸收促进作用的研究进展［J］. 中华中医药杂志，2019， 34（6）： 2589-2592.

LAN Y， WU Q， MAO Y Q， et al. Cytotoxicity and enhancement activity of essential oil from Zanthoxylum bungeanum Maxim.as a natural transdermal penetration enhancer［J］. J Zhejiang Univ Sci B， 2014， 15（2）： 153-164.

王曙东，刘文雅，王争，等. 不同促渗剂对复方红茴香喷雾剂体外透皮吸收的影响［J］. 南京中医药大学学报，2015， 31（1）： 84-86.

兰颐，王景雁，刘艳，等. 萜烯类经皮促透剂对皮肤活性表皮层的影响及其机制研究［J］. 中国中药杂志，2015， 40（4）： 643-648.

CHU S Y， CHOU C H， HUANG H D， et al. Mechanical stretch induces hair regeneration through the alternative activation of macrophages［J］. Nat Commun， 2019， 10（1）： 1524.

CHEN C C， WANG L， PLIKUS M V， et al. Organ-level quorum sensing directs regeneration in hair stem cell populations［J］. Cell， 2015， 161（2）： 277-290.

SHARP L L， JAMESON J M， CAUVI G， et al. Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1［J］. Nat Immunol， 2005， 6（1）： 73-79.

ITO M， YANG Z， ANDL T， et al. Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding［J］. Nature， 2007， 447（7142）： 316-320.

NAGAO K， KOBAYASHI T， MORO K， et al. Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin［J］. Nat Immunol， 2012， 13（8）： 744-752.

ALI N， ZIRAK B， RODRIGUEZ R S， et al. Regulatory T cells in skin facilitate epithelial stem cell differentiation［J］. Cell， 2017， 169（6）： 1119-1129.

LIU X Y， ZHOU H F， PAN Y L， et al. Electro-acupuncture stimulation protects dopaminergic neurons from inflammation-mediated damage in medial forebrain bundle-transected rats［J］. Exp Neurol， 2004， 189（1）： 189-196.

MAEDA T， TANIGUCHI M， MATSUZAKI S， et al. Anti-inflammatory effect of electroacupuncture in the C3H/HeJ mouse model of alopecia areata［J］. Acupunct Med， 2013， 31（1）： 117-119.

YU A J， LUO Y J， XU X G， et al. A pilot split-scalp study of combined fractional radiofrequency microneedling and 5% topical minoxidil in treating male pattern hair loss［J］. Clin Exp Dermatol， 2018， 43（7）： 775-781.

KIM H S， CHO D H， KIM H J， et al. Immunoreactivity of corticotropin-releasing hormone， adrenocorticotropic hormone and alpha-melanocyte-stimulating hormone in alopecia areata［J］. Exp Dermatol， 2006， 15（7）： 515-522.

袁权，诸毅晖，裴钰，等. 针刺对下丘脑-垂体-肾上腺轴的调整作用［J］. 时珍国医国药，2012， 23（7）： 1795-1797.

谢光春，杨名己，魏大能，等. 梅花针叩刺治疗斑秃的HPA轴机制探讨［J］. 湖南中医杂志，2016， 32（12）： 99-101.

高建英，刘海金，谢亚彬，等. 腹针结合艾灸治疗男性气血两虚型脂溢性脱发疗效观察［J］. 现代中西医结合杂志，2017， 26（3）： 307-308， 316.

BOUZARI N， FIROOZ A R. Lasers may induce terminal hair growth［J］. Dermatol Surg， 2006， 32（3）： 460.

LEE H E， LEE S H， JEONG M， et al. Trichogenic photostimulation using monolithic flexible vertical AlGaInP light-emitting diodes［J］. ACS Nano， 2018， 12（9）： 9587-9595.

FAN S M， CHANG Y T， CHEN C L， et al. External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway［J］. Proc Natl Acad Sci U S A， 2018， 115（29）： E6880-E6889.

FENNICHE S， HAMMAMI H， ZAOUAK A. Association of khellin and 308-nm excimer lamp in the treatment of severe alopecia areata in a child［J］. J Cosmet Laser Ther， 2018， 20（3）： 156-158.

LU M， QU A， LI S， et al. Mitochondria-targeting plasmonic spiky nanorods increase the elimination of aging cells in vivo［J］. Angew Chem Int Ed Engl， 2020， 59（22）： 8698-8705.

MATSUMURA H， MOHRI Y， BINH N T， et al. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis［J］. Science， 2016， 351（6273）： aad4395.

CHEN C C， MURRAY P J， JIANG T X， et al. Regenerative hair waves in aging mice and extra-follicular modulators follistatin， dkk1， and sfrp4［J］. J Invest Dermatol， 2014， 134（8）： 2086-2096.

DE KEIZER P L， PACKER L M， SZYPOWSKA A A， et al. Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence［J］. Cancer Res， 2010， 70（21）： 8526-8536.

DE KEIZER P L. The fountain of youth by targeting senescent cells？［J］. Trends Mol Med， 2017， 23（1）： 6-17.

GOLBERG A， KHAN S， BELOV V， et al. Skin rejuvenation with non-invasive pulsed electric fields［J］. Sci Rep， 2015（5）： 10187.

BENJAMIN B， ZIGINSKAS D， HARMAN J， et al. Pulsed electrostatic fields （ETG） to reduce hair loss in women undergoing chemotherapy for breast carcinoma： a pilot study［J］. Psychooncology， 2002， 11（3）： 244-248.

YAO G， JIANG D， LI J， et al. Self-activated electrical stimulation for effective hair regeneration via a wearable omnidirectional pulse generator［J］. ACS Nano， 2019， 13（11）： 12345-12356.

Views

1179

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical study on treatment of spinal cord injury by oral administration of traditional Chinese herbal medicine combined with transcutaneous electrical acupoint stimulation based on the theory of warming kidneys and unblocking Du channel

Research progress on Chinese medicine in prevention and treatment of diabetic nephropathy by interfering with NF⁃κB related signaling pathways

Research progress in non⁃pharmacological conservative treatment of lumbar intervertebral disc herniation

Research progress on mechanism of Chinese medicine regulating the macrophages against atherosclerosis

Research progress on active components and mechanism of traditional Chinese herbal medicine for antianxiety

Related Author

No data

Related Institution

Department of Acupuncture and Massage Rehabilitation， The First Hospital of Hunan University of Chinese Medicine

Center of Medical Laboratory and Pathology， The First Hospital of Hunan University of Chinese Medicine

Department of Anesthesiology， Xiangya Hospital Central South University

College of Pharmacy， Heilongjiang University of Traditional Chinese Medicine

Wuxi Xinwu District Xinrui Hospital， Wuxi Branch of Ruijin Hospital Affiliated to Shanghai JiaoTong University School of Medicine

⁰