Study on the relationship between functional bowel disorders and anxiety and depressive states in epileptic patients and the distribution of traditional Chinese medicine syndromes

Yangyang YU; Chao GU; Chunxu WANG; Canxing YUAN

doi:10.16305/j.1007-1334.2021.2107078

您当前的位置：

首页 >

文章列表页 >

Study on the relationship between functional bowel disorders and anxiety and depressive states in epileptic patients and the distribution of traditional Chinese medicine syndromes

更新时间：2022-08-03

- Study on the relationship between functional bowel disorders and anxiety and depressive states in epileptic patients and the distribution of traditional Chinese medicine syndromes
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 11, Pages: 23-26(2021)
- 作者机构：
  
  1.上海中医药大学附属龙华医院脑病科（上海　200032）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.2107078
  CLC：
扫描看全文
Yangyang YU, Chao GU, Chunxu WANG, et al. Study on the relationship between functional bowel disorders and anxiety and depressive states in epileptic patients and the distribution of traditional Chinese medicine syndromes. [J]. Shanghai Journal of Traditional Chinese Medicine 55(11):23-26(2021)
DOI：

Yangyang YU, Chao GU, Chunxu WANG, et al. Study on the relationship between functional bowel disorders and anxiety and depressive states in epileptic patients and the distribution of traditional Chinese medicine syndromes. [J]. Shanghai Journal of Traditional Chinese Medicine 55(11):23-26(2021) DOI： 10.16305/j.1007-1334.2021.2107078.

摘要

目的,2,探讨癫痫患者功能性肠病（FBD）与焦虑、抑郁状态的关系及中医证型分布规律。,方法,2,将306例癫痫患者根据FBD的患病情况分为伴FBD组（172例）、不伴FBD组（134例），收集病例资料，分析比较两组一般情况（性别、年龄、病程、脑电图、认知功能）、焦虑状态自评量表（SAS）评分、抑郁状态自评量表（SDS）评分及中医证候分布情况，采用logistic回归分析癫痫FBD的影响因素。,结果,2,①伴FBD组年龄大于不伴FBD组，病程长于不伴FBD组，脑电图异常率高于不伴FBD组（,P,<,0.001，,P,<,0.05）。②伴FBD组SAS、SDS评分高于不伴FBD组（,P,<,0.001），SAS、SDS评分异常率高于不伴FBD组（,P,<,0.001）。③logistic回归分析结果显示，癫痫患者的病程、年龄、SAS评分为癫痫伴发FBD的影响因素（,P,<,0.05），其中SAS评分异常的癫痫患者伴发FBD的可能性是SAS评分正常者的6.104倍 [,OR,=6.104，95%,CI,（3.416～10.906），,P,<,0.001]。④伴FBD组患者心脾两虚证最多见（27.91%），不伴FBD组患者瘀阻脑络证最多见（41.79%）；痰、虚、瘀三大中医证型分布显示，伴FBD组患者虚证最多见（44.19%），不伴FBD组患者痰证最多见（52.24%）。,结论,2,与不伴FBD比较，伴FBD的癫痫患者焦虑、抑郁情绪更加严重，癫痫病程、患者年龄、焦虑状态均为癫痫患者发生FBD的影响因素；癫痫伴FBD患者以虚证多见，其中占比最高的为心脾两虚证。

Abstract

Objective,2,To explore the relationship between functional bowel disorder (FBD) and anxiety and depressive states in patients with epilepsy and the distribution of traditional Chinese medicine (TCM) syndromes., Methods,2,A total of 306 patients with epilepsy were divided into the group with FBD (,n,=172) and the group without FBD (,n,=134) according to the disease status of FBD. The case data were collected and analyzed to compare the general conditions (gender, age, disease duration, EEG, cognitive function), Self-rating Anxiety Scale (SAS) scores, Self-rating Depression Scale (SDS) scores and the distribution of TCM symptoms between the two groups. Logistic regression was used to analyze the factors influencing FBD in epileptic patients.,Results,2,①Compared with the conditions in the group without FBD, the age was higher, the disease duration was longer and the EEG abnormality rate was higher in the group with FBD (,P,<,0.001,P,<,0.05). ②SAS and SDS scores were higher in the group with FBD than the scores in the group without FBD (,P,<,0.001), and the abnormal rates of SAS and SDS scores were higher than those in the group without FBD (,P,<,0.001). ③According to the results of logistic regression analysis, the disease duration, age, and SAS scores were influencing factors of FBD in epileptic patients (,P,<,0.05), and epileptic patients with abnormal SAS scores were 6.104 times more likely to have FBD than those with normal SAS scores [,OR,=6.104, 95% ,CI, (3.416-10.906),P,<,0.001]. ④The heart and spleen dual deficiency syndrome was the most common syndrome in the group with FBD (27.91%), and the stasis blocking brain collaterals syndrome was most common syndrome in the group without FBD (41.79%). The distribution of TCM syndromes of phlegm, deficiency and stasis showed that most cases in the group with FBD had deficiency syndomes (44.19%) and most cases in the group without FBD had phlegm syndromes (52.24%).,Conclusion,2,Compared with conditions in the group without FBD, epileptic patients with FBD had more severe anxiety and depression. The disease duration, age, and anxiety and depressive states are all influencing factors in the occurrence of FBD in patients with epilepsy. Epileptic patients with FBD are more likely to have deficiency syndromes, and the heart and spleen dual deficiency syndrome has the highest proportion.

关键词

癫痫功能性肠病焦虑状态抑郁状态中医证型

Keywords

epilepsyfunctional bowel disorderanxiety statedepressive statetraditional Chinese medicine syndrome

references

周新雨，洪震，虞培敏，等. 癫痫伴焦虑诊断治疗的中国专家共识[J]. 癫痫杂志，2018, 4(3): 185-189.

施茜馨，马融，张喜莲，等. 基于脑肠轴理论探讨中医从肝脾论治癫痫研究进展[J]. 中华中医药杂志，2019, 34(10): 4761-4763.

YANO J, YU K, DONALDSON G, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis[J]. Cell, 2015, 161(2): 264-276.

MARTIN C R, OSADCHIY V, KALANI A, et al. The brain-gut-microbiome axis[J]. Cell Mol Gastroenterol Hepatol, 2018, 6(2): 133-148.

储志远. 肠道菌群组成与癫痫发病的相关性研究[D]. 蚌埠：蚌埠医学院，2019.

徐铭悦，王瑜，李娟，等. 甘麦大枣汤对抑郁症模型大鼠前额叶和杏仁核中BDNF、SERT基因表达及血清5-HT水平的影响[J]. 上海中医药杂志，2019, 53(3): 89-99.

游懿君，韩小龙，郑晓皎，等. 肠道菌群与大脑双向互动的研究进展[J]. 上海交通大学学报（医学版），2017, 37(2): 253-257.

聂兰. 基于罗马Ⅳ标准的功能性肠病中医证型分布规律研究[D]. 长沙：湖南中医药大学，2018.

靳淼，安红梅，王秀薇，等. 固本定痫镇痛合剂联合蝎蜈胶囊治疗癫痫临床观察[J]. 上海中医药杂志，2011, 45(5): 40-42.

李华霞，玉倩，汪顺贵，等. 柴胡疏肝汤加减联合抗癫痫药治疗癫痫的疗效及安全性Meta分析[J]. 中华中医药学刊，2020, 38(8): 151-156.

张媛，聂莉媛，张青，等. 中医药治疗癫痫的系统评价[J]. 中华中医药杂志，2016, 31(12): 5266-5270.

FISHER R, ACEVEDO C, ARZIMANOGLOU A, et al. ILAE official report: a practical clinical definition of epilepsy[J]. Epilepsia, 2014, 55(4): 475-482.

中国抗癫痫协会. 临床诊疗指南：癫痫病分册（2015修订版）[M]. 北京：人民卫生出版社，2015: 17-21.

FOLSTEIN M, FOLSTEIN S, MC H. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician[J]. J Psychiatr Res, 1975, 12(3): 189-198.

NASREDDINE Z, PHILLIPS N, BRDIFIAN V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment[J]. J Am Geriatr Soc, 2005, 53(4): 695-699.

DROSSMAN D A, HASLER W L. Rome IV-functional GI disorders: Disorders of gut-brain interaction[J]. Gastroenterology, 2016, 150(6): 1257-1261.

ENCK P, AZIZ Q, BAR BARA G, et al. Irritable bowel syndrome[J/OL]. Nat Rev Dis Primers, 2016(2): 16014[2021-06-30]. https://pubmed.ncbi.nlm.nih.gov/27159638/.

ZUNG W W. A rating instrument for anxiety disorders[J]. Psychosomatics, 1974, 12(6): 371-379.

ZUNG W W. A self-rating depression scale[J]. Arch Gen Psychiatry, 1965(12): 63-70.

国家中医药管理局. 中医病证诊断疗效标准[M]. 北京：中国中医药出版社，2018: 35-36.

国家药品监督管理局. 中药新药临床研究指导原则（试行）[M]. 北京：中国医药出版社，2002: 99-104.

国家技术监督局. 中医临床诊疗术语证候部分：GB/T 16751.2－1997 [S]. 北京：中国标准出版社，1997: 43.

黄波，李春. 癫痫伴情绪障碍者相关影响因素分析[J]. 中国当代医药，2017, 24(10): 56-58.

岳李. 功能性胃肠病患者精神心理因素调查及抗抑郁治疗效果分析[J]. 中国实用神经疾病杂志，2012, 15(18): 43-44.

苗艳芳，王玉贤. 腹泻型肠易激综合征（肝郁脾虚证）的中医研究进展[J]. 上海中医药杂志，2021, 55(7): 91-94.

叶青，周洁，袁灿兴，等. 镇惊泻火颗粒治疗痰热内扰型轻中度焦虑症的随机、双盲、安慰剂对照研究[J]. 上海中医药杂志，2016, 50(12): 37-40.

Views

292

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Retrospective study on factors related to recurrence and metastasis after radical resection of colorectal cancer

Establishment and evaluation of a nomogram for predicting traditional Chinese medicine syndromes of menopause⁃like syndrome after endocrine therapy for postoperative breast cancer

Differences in autophagic histone code in patients with myelodysplastic syndrome of different traditional Chinese medicine syndromes

Analysis of factors influencing sleep disorders and the distribution characteristics of traditional Chinese medicine syndromes in people with early⁃or mid⁃stage Parkinson’s disease

Clinical guidelines for diagnosis and treatment of scapulohumeral periarthritis in traditional Chinese medicine orthopedics and traumatology： T/CACM 1179—2019

Related Author

No data

Related Institution

Institute of Liver Diseases， Shanghai University of Traditional Chinese Medicine， MOE Key Laboratory of Liver and Kidney Diseases

Department of Oncology， Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Cancer Institute， Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Guangxi Medical University Cancer Hospital

Guangxi University of Traditional Chinese Medicine

⁰