Theory of "hidden toxicity due to vital qi deficiency" as core pathogenesis for subclinical stage of cancer metastasis

Jianhui TIAN; Bin LUO; Zujun QUE; Jialiang YAO; Yun YANG; Yan LI

doi:10.16305/j.1007-1334.2021.2105080

您当前的位置：

首页 >

文章列表页 >

Theory of "hidden toxicity due to vital qi deficiency" as core pathogenesis for subclinical stage of cancer metastasis

更新时间：2022-08-03

- Theory of "hidden toxicity due to vital qi deficiency" as core pathogenesis for subclinical stage of cancer metastasis
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 10, Pages: 1-3,13(2021)
- 作者机构：
  
  1.上海中医药大学附属市中医医院（上海　200071）
  2.上海市中医医院肿瘤研究所（上海　200071）
  3.上海中医药大学附属龙华医院（上海　200032）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.2105080
  CLC：
扫描看全文
Jianhui TIAN, Bin LUO, Zujun QUE, et al. Theory of "hidden toxicity due to vital qi deficiency" as core pathogenesis for subclinical stage of cancer metastasis. [J]. Shanghai Journal of Traditional Chinese Medicine 55(10):1-3,13(2021)
DOI：

Jianhui TIAN, Bin LUO, Zujun QUE, et al. Theory of "hidden toxicity due to vital qi deficiency" as core pathogenesis for subclinical stage of cancer metastasis. [J]. Shanghai Journal of Traditional Chinese Medicine 55(10):1-3,13(2021) DOI： 10.16305/j.1007-1334.2021.2105080.

摘要

提出并验证“正虚伏毒”为癌症转移亚临床阶段的核心病机。癌症转移发生中存在“正气”与“伏毒”交争的过程，即“正胜则毒伏不作、正虚则毒出为病”，其实质是癌细胞与宿主抑癌力量之间的博弈。实体瘤根治术后残余癌细胞（如循环肿瘤细胞、播散肿瘤细胞、休眠肿瘤细胞等）潜伏于体内处于休眠期或静止期，待正气亏虚时（即免疫监视和免疫清除效率下降时），癌细胞从静止期进入增殖期而导致临床转移事件的发生。因此，从形、气、神层面全面调护患者正气是预防癌症转移发生的关键策略。

Abstract

The theory of "hidden toxicity due to vital qi deficiency" as the core pathogenesis of cancer metastasis in the subclinical stage has been proposed and verified. In the process of cancer metastasis, there is a struggle between "vital qi" and "hidden toxicity" . "If vital qi prevails, the hidden toxicity will be subdued without causing diseases; however, if vital qi is weak, the hidden toxicity will burst out to cause diseases" . The essence actually is the fight between cancer cells and the host’s cancer suppression power. After the radical resection of solid tumors, the residual cancer cells (e.g., circulating tumor cells, disseminated tumor cells, dormant tumor cells, etc.) are latent in the body, being in the dormant or quiescent phase. When there is a deficiency of vital qi (i.e., when the immune surveillance and immune clearance efficiency decreases), cancer cells will enter the proliferative phase from the quiescent phase, leading to the occurrence of clinical metastasis. Therefore, the key strategy to prevent the occurrence of cancer metastasis is to comprehensively regulate the patient’s vital qi in terms of form, qi and spirit.

关键词

肿瘤转移肺癌亚临床阶段正虚伏毒中医病机循环肿瘤细胞免疫逃逸

Keywords

cancer metastasislung cancersubclinical stagehidden toxicity due to vital qi deficiencytraditional Chinese medicine pathogenesiscirculating tumor cellsimmune escape

references

田建辉. 中西医融合提高肿瘤综合治疗疗效的思考[J]. 中国中西医结合杂志，2017, 37(9): 1032-1033.

SIEGEL R L, MILLER K D, JEMAL A. Cancer statistics, 2020[J]. CA Cancer J Clin, 2020, 70(1): 7-30.

YANG D, LIU Y, BAI C, et al. Epidemiology of lung cancer and lung cancer screening programs in China and the United States[J]. Cancer Lett, 2020, 468 (1):82:87.

ANDERSON R L, BALASAS T, CALLAGHAN J, et al. A framework for the development of effective anti-metastatic agents[J]. Nature Rev Clin Oncol, 2019, 16(3): 185-204.

SHERMAN R M, SALZBERG S L. Pan-genomics in the human genome era[J]. Nat Rev Genet, 2020, 21(4): 243-254.

REYNA M A, HAAN D, PACZKOWSKA M, et al. Pathway and network analysis of more than 2500 whole cancer genomes[J]. Nat Commun, 2020(11): 729.

JIN X, DEMERE Z, NAIR K, et al. A metastasis map of human cancer cell lines[J]. Nature, 2020, 588(7837): 331-336.

FAU H S, WEICHSELBAUM R R. Oligometastases[J]. J Clin Oncol, 1995, 13(1): 8-10.

BIDARD F C, PIERGA J Y, SORIA J C, et al. Translating metastasis-related biomarkers to the clinic—progress and pitfalls[J]. Nature Rev Clin Oncol, 2013, 10(3): 169-179.

罗斌，阙祖俊，朱丽华，等. 非小细胞肺癌患者外周血CD11b+CD33+CD15+CD14-及CD11b+CD33+CD15-CD14+髓系细胞的比例变化及临床意义[J]. 现代免疫学, 2017, 37(1): 25-31.

衣秀秀，罗斌，钱芳芳，等. 从免疫抑制和循环肿瘤细胞探讨肺癌核心病机“正虚伏毒”的生物学基础[J]. 世界科学技术-中医药现代化，2019,21(5): 963-969.

朱丽华，周蕾，罗斌，等. 284例非小细胞肺癌患者循环肿瘤细胞与临床特征及凝血功能的相关性[J]. 肿瘤预防与治疗，2020, 33(9): 746-752.

田建辉，罗斌，毕凌，等. 非小细胞肺癌循环肿瘤细胞表达规律及其与“伏邪”致病关系的研究[J]. 上海中医药杂志，2016, 50(1): 15-19, 33.

QUE Z, LUO B, ZHOU Z, et al. Establishment and characterization of a patient-derived circulating lung tumor cell line in vitro and in vivo[J]. Cancer Cell Int, 2019(19): 21.

罗斌，阙祖俊，姚嘉良，等. 人非小细胞肺癌循环肿瘤细胞系的建立及意义——肺癌转移病因“伏毒”的本质研究[J]. 世界科学技术-中医药现代化，2019, 21(5): 983-987.

田建辉. “正虚伏毒”为肺癌发病的核心病机[J]. 上海中医药杂志，2016, 50(12): 10-14.

田建辉，罗斌，刘嘉湘. 肺癌“正虚伏毒”病机的生物学基础(一)——基于免疫紊乱之肺癌“正虚”探要[J]. 上海中医药杂志，2018, 52(1): 1-4.

田建辉，罗斌. 肺癌“正虚伏毒”病机的生物学基础(二)——基于隐匿性肿瘤细胞之肺癌“伏毒”病机探要[J]. 上海中医药杂志，2018, 52(2): 6-10.

罗斌，姚嘉良，田建辉，等. 髓源性抑制细胞与肺癌转移前微环境的形成[J]. 中国免疫学杂志，2020, 36(9): 1136-1139,1144.

阙祖俊，罗斌，董昌盛，等. “正虚伏毒”肺癌研究平台的构建[J]. 上海中医药杂志，2019, 53(4): 11-16.

QUE Z, ZHOU Z, LUO B, et al. Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells[J]. BMC Complement Altern Med, 2019, 19(1): 204.

刘海涛. 调“神”治疗肺癌的理论、临床与实验研究[D]. 上海：上海中医药大学，2020.

韩岚，张纯刚，林朝展，等. 2019年国家自然科学基金中药药理学研究方向项目申请与资助情况分析[J]. 中国中药杂志，2020, 45(1): 209-213.

LIU X, YI Y. Recent updates on Sintilimab in solid tumor immunotherapy[J]. Biomark Res, 2020, 8(1): 69.

仝小林. 态靶医学——中医未来发展之路[J]. 中国中西医结合杂志，2021, 41(1): 16-18.

Views

607

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Discussion on traditional Chinese medicine pathogenesis of brain metastases from lung cancer based on theory of “lung⁃brain correlation”

Construction of lung cancer research platform under the theory of “hidden toxicity due to vital qi deficiency”

Biological basis of hidden toxicity due to vital qi deficiency in lung cancer:Ⅱ. Discussion on hidden toxicity in lung cancer from occult tumor cells

Biological basis of hidden toxicity due to vital qi deficiency in lung cancer:Ⅰ. Discussion on vital qi deficiency in lung cancer from immunologic derangement

Mechanism of Astragaloside Ⅳ regulates extracellular vesicles⁃mediated JMJD3/H3K27me3/OPN pathway against colorectal cancer liver metastasis

Related Author

No data

Related Institution

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Shanghai University of Traditional Chinese Medicine

Department of Oncology,Longhua Hospital, Shanghai University of Traditional Chinese Medicine

Cancer Institute of Chinese Medicine,Shanghai Academy of Traditional Chinese Medicine

Department of Oncology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

⁰