Objective,2,To observe the clinical effect of acupuncture and medication combined prevention and treatment of migraine of liver-yang hyperactivity syndrome based on the method of clearing liver and purging fire.,Methods,2,A total of 159 patients with migraine of liver-yang hyperactivity syndrome were randomly divided into traditional Chinese herbal medicine (TCHM) group, acupuncture and medication combined (AMC) group 1 and AMC group 2, with 53 cases in each group. The TCHM group was administered with Qinggan Huayu Prescription, the AMC group 1 was administered with Qinggan Huayu Prescription together with conventional acupuncture, and the AMC group 2 was administered with Qinggan Huayu Prescription together with liver-clearing and fire-purging acupuncture therapy. The course of treatment in each group was 8 weeks, with 4 weeks of follow-ups after treatment. The clinical effect was observed, and the changes of migraine symptoms (headache attack frequency, headache duration, headache degree, accompanying symptoms) scores and traditional Chinese medicine (TCM) syndrome scores before and after treatment were compared.,Results,2,①During the trial, there were 4 drop-out cases in the TCHM group, 7 drop-out cases in the AMC group 1, and 6 drop-out cases in the AMC group 2. Finally, 142 cases completed the trail, including 49 cases in the TCHM group, 46 cases in the AMC group 1, and 47 cases in the AMC group 2. ②The effective rate of TCHM group, AMC group 1 and AMC group 2 was 57.41%, 76.09%, and 95.74%, respectively. According to the inter-group comparisons, the AMC group 1 and AMC group 2 showed better clinical effects than the TCHM group (,P,<,0.05), and AMC group 2 had even better clinical effects than AMC group 1 (,P,<,0.05). ③According to the intra-group comparisons before treatment and after 4 weeks of treatment, 8 weeks of treatment, and 4 weeks of follow-ups, the scores of TCM syndromes, the total scores of migraine symptoms, and the scores of various items (headache attack frequency, headache duration, headache degree, and accompanying symptoms) all decreased in each group (,P,<,0.05). ④The inter-group comparisons after 4 weeks of treatment showed that the differences in the total score of migraine symptoms and the score of headache degree of the AMC group 1 and the AMC group 2 were greater than those of the TCHM group (,P,<,0.05), and the difference in the score of headache degree of the AMC group 2 was greater than that of the AMC group 1 (,P,<,0.05). According to the inter-group comparisons after 8 weeks of treatment and 4 weeks of follow-ups, the differences in scores of headache attack frequency, headache duration, headache degree, total scores of migraine symptoms and TCM syndrome scores of AMC group 1 and AMC group 2 were greater than those of TCHM group (,P,<,0.05), and the differences in scores of headache attack frequency, headache duration, headache degree, total scores of migraine symptoms and TCM syndrome scores of AMC group 2 were greater than those of AMC group 1 (,P,<,0.05).,Conclusion,2,The liver-clearing and fire-purging based acupuncture combined with medication has achieved satisfactory results in preventing and treating migraine of liver-yang hyperactivity syndrome as it can effectively reduce the number of migraine attacks, shorten the duration of headache, relieve the degree of headache and improve TCM syndromes.