Objective,2,To observe the clinical efficacy and safety of Gu’s traditional surgical treatment of Hongyu Yin combined with cut and suture-dragging therapy for the perianal fistulizing Crohn’s disease(pfCD).,Methods,2,The clinical data of 66 Crohn’s disease patients with perianal fistulizing diagnosed and treated in our hospital from June 2007 to June 2017 were retrospectively analyzed. According to the treatment methods, patients were divided into treatment group(35 cases) and control group(31 cases).The treatment group was treated with Hongyu Yin combined with cut and suture-dragging therapy, while the control group was treated with cut and suture-dragging therapy. After 12 weeks, the clinical recurrence rate, healing time, therapeutic effect of TCM syndrome, the total scores of perianal disease activity index(PDAI) and main sub-items scores, the total scores of Crohn’s disease activity index(CDAI) and main sub-items scores were comparatively analyzed, and safety was assessed simultaneously.,Results,2,①There was no statistically significant difference in baseline data between the treatment group and the control group in terms of gender, age, surgical history, age at diagnosis, type of anal fistula, and lesion location (,P,>,0.05).②After treatment, there was no significant difference in the recurrence rate in two groups(,P,>,0.05), and the average healing time and the therapeutic effect of TCM syndrome in the treatment group was significantly better than those in the control group(,P,<,0.05). ③After treatment, the total scores of PDAI and main sub-items scores in the two groups were decreased(,P,<,0.05), and the scores of the treatment group were lower than those of the control group (,P,<,0.05). ④After treatment, the total scores of CDAI, abdominal pain score, and diarrhea score of the two groups were significantly decreased(,P,<,0.05), and the scores of the treatment group were lower than those of the control group(,P,<,0.05), but there was no significant difference in fever score between the two groups(,P,>,0.05). ⑤There was no significant difference in the incidence of adverse reactions between the two groups(,P,>,0.05).,Conclusion,2,Compared with suture-dragging therapy alone, Hongyu Yin combined with suture-dragging therapy could achieve satisfactory results in treating with pfCD patients as it could significantly shorten the healing time, alleviate disease symptoms and improve the quality of life while having safety.