Multicenter study on distribution of TCM syndrome types and clinical features of bladder cancer patients in Shanghai

Huiming BAI; Mingyue TAN; Bin SUN; Chao YU; Libin YANG; Yuhui ZHAO; Zhihang ZHANG; Youkang ZHAO; Lei CHEN

doi:10.16305/j.1007-1334.2021.2101154

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Multicenter study on distribution of TCM syndrome types and clinical features of bladder cancer patients in Shanghai

更新时间：2022-08-03

- Multicenter study on distribution of TCM syndrome types and clinical features of bladder cancer patients in Shanghai
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 10, Pages: 14-18(2021)
- 作者机构：
  
  1.上海中医药大学附属龙华医院泌尿外科（上海　200032）
  2.上海市第一人民医院泌尿外科（上海　200080）
  3.上海交通大学医学院附属新华医院崇明分院泌尿外科（上海　202150）
  4.上海市名中医周智恒泌尿男科工作室（上海　200032）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.2101154
  CLC：
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Huiming BAI, Mingyue TAN, Bin SUN, et al. Multicenter study on distribution of TCM syndrome types and clinical features of bladder cancer patients in Shanghai. [J]. Shanghai Journal of Traditional Chinese Medicine 55(10):14-18(2021)
DOI：

Huiming BAI, Mingyue TAN, Bin SUN, et al. Multicenter study on distribution of TCM syndrome types and clinical features of bladder cancer patients in Shanghai. [J]. Shanghai Journal of Traditional Chinese Medicine 55(10):14-18(2021) DOI： 10.16305/j.1007-1334.2021.2101154.

摘要

目的,2,探讨上海地区膀胱癌患者中医证型分布情况以及临床特征。,方法,2,选择上海地区膀胱癌患者525例，采用中医证候问卷的方法调查中医证型分布情况，同时调查病理结果（是/非浸润性膀胱癌），然后在非浸润性膀胱癌患者中再进一步调查患者的病理细胞分级（高/低危）、膀胱镜检查的相关情况（肿瘤数目：单发/多发）、病史情况（发病年龄；发病情况：首发/复发），采用生活质量问卷评定患者的生存质量。,结果,2,①525例患者中，男性患者占比68.0%，女性患者占比32.0%。中医证型中，瘀毒蕴结型、湿热下注型占比较高，其后依次是肾阴不足型、无证可辨/其他型和脾肾两虚型；病理显示非浸润性膀胱癌和浸润性膀胱癌患者的中医证型分布存在差异（,P,<,0.05）。非浸润性膀胱癌患者占比最多的中医证型为湿热下注型，浸润性膀胱癌患者占比最多为瘀毒蕴结型。②非浸润性膀胱癌患者中，低级别占比最多的中医证型是湿热下注型，高级别是瘀毒蕴结型。③非浸润性膀胱癌主要中医证型中，湿热下注型的排尿症状、肠道症状评分明显高于其他证型（,P,<,0.05），瘀毒蕴结型疼痛症状评分明显高于其他证型（,P,<,0.05）。,结论,2,上海地区膀胱癌的中医证型以湿热下注、瘀毒蕴结两型为主，发病最多的非浸润性膀胱癌患者中亦是呈现此两种证型占比最多。非浸润性膀胱癌与浸润性膀胱癌中医证型分布特征比较有差异，非浸润性膀胱癌患者中瘀毒蕴结型因较其他证型病理级别、浸润性和复发率等方面差异明显，尤需引起临床重视。

Abstract

Objective,2,To investigate the distribution and clinical features of TCM syndromes in bladder cancer patients in Shanghai.,Methods,2,525 cases of bladder cancer in Shanghai were investigated by TCM syndrome questionnaire, and the pathological results (yes/non-invasive bladder cancer) were investigated. Then the pathological cell grade (high/low risk), cystoscopy (number of tumors: single/multiple), history (age of onset, incidence: initial/recurrence) were investigated in the non-invasive bladder cancer patients and life scale was used to evaluate the quality of life.,Results,2,①Among 525 patients, male patients accounted for 68.0% and female patients accounted for 32.0%. In the patients’ TCM syndrome, the damp-heat perfusion type and stasis toxin accumulation type were relatively high, Then followed by deficiency of kidney yin type, non-documented/other TCM syndrome type and deficiency of spleen and kidney yang; Pathology showed that there was a difference in TCM syndrome distribution between non-invasive bladder cancer and invasive bladder cancer (,P,<,0.05). The highest proportion of TCM syndrome type was damp-heat perfusion type in non-invasive bladder cancer. The most invasive bladder cancer patients was stasis toxin accumulation type. ②The most middle and low grade TCM syndrome in non-invasive bladder cancer patients was damp-heat perfusion type. The high level was stasis toxin accumulation type. ③Among the main TCM syndromes of non-invasive bladder cancer, the scores of urination symptom and intestinal symptom of damp-heat perfusion type were significantly higher than those of other syndromes (,P,<,0.05), and the score of pain symptom of stasis toxin accumulation type was significantly higher than that of other syndromes (,P,<,0.05).,Conclusions,2,The TCM syndromes of bladder cancer in Shanghai are mainly damp-heat perfusion type and stasis toxin accumulation type, among which non-invasive bladder cancer had the most incidence. The distribution of TCM syndromes of non-invasive bladder cancer was different from that of invasive bladder cancer. The non-invasive bladder cancer patients with stasis toxin accumulation type were significantly different from other syndrome types in terms of pathological grade, infiltration and recurrence rate, which should be paid attention in clinical.

关键词

膀胱癌非浸润性中医证候流行病学生存质量瘀毒蕴结

Keywords

bladder cancernon-invasiveTCM syndromesepidemiologyquality of lifestasis toxin accumulation

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