Objective,2,To observe the clinical effect of modified Tuduzi Buqi Decoction combined with western medicine conventional therapy on the treatment of refractory ascites in liver cirrhosis.,Methods,2,Fifty-seven patients with refractory ascites in liver cirrhosis were divided into treatment group (,n,=32) and control group (,n,=25). The control group was administered with western medicine conventional therapy, while the treatment group was additionally administered with Tuduzi Buqi Decoction besides the western medicine conventional therapy. The course of treatment in both groups lasted 14 days. We compared the changes of ascites related indicators (24-hour urine volume, body mass, abdominal circumference, and ascites depth in supine position) and laboratory related indicators (liver function, renal function, electrolyte, and coagulation function).,Results,2,①According to the intra-group comparison before and after 7 days of treatment, in the treatment group the 24-hour urine volume increased (,P,<,0.05), and the body mass, abdominal circumference, and depth of ascites in supine position decreased (,P,<,0.05). However, there was no significant difference in the above indicators in the control group (,P,>,0.05). According to the intra-group comparison before and after 14 days of treatment, there were significant differences in the above-mentioned ascites related indicators in both groups (,P,<,0.05). According to the inter-group comparison after 7 days of treatment and 14 days of treatment, there were significant differences in 24-hour urine volume and ascites depth in supine position between the two groups (,P,<,0.05). ②According to the intra-group comparison before and after 14 days of treatment, the serum creatinine level in the control group increased (,P,>,0.05), but there was no significant difference in indicators of liver function, renal function, electrolyte, and coagulation function in the treatment group (,P,>,0.05). According to the inter-group comparison after 14 days of treatment, there was no significant difference in the above indicators between the groups (,P,>,0.05).,Conclusion,2,Compared with the single use of western medicine conventional therapy, the combined use of Tuduzi Buqi Decoction and western medicine is more conducive to the resolution of refractory ascites in liver cirrhosis without increasing the risk of renal function injury and electrolyte disturbance.