Objective,2,To observe the effect of Bushen Jiedu Recipe combined with palliative chemotherapy on cancer-related fatigue (CRF) in patients with advanced colorectal cancer (ACC).,Methods,2,In a prospective, randomized, double-blind, placebo-controlled trial design, 72 ACC patients with cancer-related fatigue were randomly divided into treatment group (,n,=36) and control group (,n,=36). The control group was administered with palliative chemotherapy combined with Bushen Jiedu Recipe placebo, while the treatment group was administered with palliative chemotherapy combined with Bushen Jiedu Recipe. The treatment lasted until the expiration of 6 chemotherapy cycles or the disease progression. The score changes of the Piper Fatigue Scale (PFS) and a Chinese version of the Brief Fatigue Inventory (BFI-C) were compared between the two groups, and the incidence of adverse reactions was observed and recorded.,Results,2,①The treatment group and the control group each shed 4 cases, and the remaining 64 subjects completed the trial, 32 cases in the treatment group and 32 cases in the control group. ②The intra-group comparison before and after treatment showed that there were significant differences in the scores of each dimension (behavioral fatigue, affective fatigue, somatosensory fatigue, cognitive emotional fatigue) and the total scores of PFS between the two groups (,P,<,0.05). After treatment, the scores of each dimension and the total scores of PFS in the treatment group were lower than those in control group (,P,<,0.05). ③According to the intra-group comparison before and after treatment, the BFI-C scores of fatigue now, usual fatigue at 24 hours, worst fatigue at 24 hours, impact on life (general activities, mood, walking, normal work, relations with other people, enjoyment of life) and the total scores differed significantly in the treatment group (,P,<,0.05), while in the control group, only differences in the BFI-C scores of worst fatigue at 24 hours, impact on general activities and mood were statistically significant (,P,<,0.05). After treatment, the scores of each dimension and total scores of BFI-C in the treatment group were lower than those in the control group (,P,<,0.05). ④There was no significant difference in the incidence of adverse reactions between groups (,P,>,0.05), and major adverse reactions were of grade Ⅰ and Ⅱ.,Conclusion,2,Bushen Jiedu Recipe combined with palliative chemotherapy can significantly reduce the serverity of cancer-related fatigue in patients with advanced colorectal cancer with good safety.