The ancient clinical application of Scutellariae Radix could be divided into "kuqin" and "tiaoqin" , their position, ways, compatibility, usage and dosage in heat clearing were different. Reasonable selection of Scutellariae Radix varieties was particularly necessary to improve the clinical efficacy. Kuqin was good at clearing heat, eliminating heat-toxin. It was often compatible with clearing heat medicine, clearing heat and detoxicating medicine and relieving cough medicine, which mainly used in treating middle and upper Jiao fire-heat syndrome and skin sores. And kuqin was usually processed with wine, and the dosage should be reduced. Tiaoqin was good at clearing dampness and heat, cooling blood heat. It was often compatible with clearing heat and cooling blood medicine, draining water and dispersing dampness medicine, which mainly used in treating middle and lower Jiao dampness-heat syndrome and blood-heat hemorrhagic syndrome. And tiaoqin was used in raw or processed with bile, and the dosage should be increased.