Research progress of traditional Chinese medicine treated myocardial hypertrophy based on mitochondrial dysfunction

Lanying YU; Xiaocui QI; Naiyan WEN; Tiantian LIU; Xun CHI; Fang LIU; Sheng LIU; Nanqi SHU; Xue WANG; Yanwei DU; Xuejiao LYU

doi:10.16305/j.1007-1334.2021.2009100

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Research progress of traditional Chinese medicine treated myocardial hypertrophy based on mitochondrial dysfunction

更新时间：2022-08-03

- Research progress of traditional Chinese medicine treated myocardial hypertrophy based on mitochondrial dysfunction
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 7, Pages: 95-100(2021)
- 作者机构：
  
  1.长春中医药大学临床医学院（吉林　长春　130117）
  2.吉林大学第二医院呼吸科（吉林　长春　130041）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.2009100
  CLC：
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Lanying YU, Xiaocui QI, Naiyan WEN, et al. Research progress of traditional Chinese medicine treated myocardial hypertrophy based on mitochondrial dysfunction. [J]. Shanghai Journal of Traditional Chinese Medicine 55(7):95-100(2021)
DOI：

Lanying YU, Xiaocui QI, Naiyan WEN, et al. Research progress of traditional Chinese medicine treated myocardial hypertrophy based on mitochondrial dysfunction. [J]. Shanghai Journal of Traditional Chinese Medicine 55(7):95-100(2021) DOI： 10.16305/j.1007-1334.2021.2009100.

摘要

综述基于线粒体功能障碍探讨中药防治心肌肥大的研究进展。回顾线粒体的结构、功能及其功能障碍时的主要表现，从线粒体能量代谢障碍、氧化应激、动力学紊乱、线粒体DNA突变、钙稳态失衡等5个方面归纳线粒体功能障碍对心肌肥大的影响，以及中医药在治疗心肌肥大中的应用概况，为今后临床治疗心肌肥大提供了新的理论依据和视角。

Abstract

This paper summarized the research progress of traditional Chinese medicine treated myocardial hypertrophy based on mitochondrial dysfunction. It reviewed the structure and function of mitochondria and the main manifestations of mitochondrial dysfunction. At the same time, it summarized the effects of mitochondrial dysfunction on myocardial hypertrophy from 5 aspects: mitochondrial energy metabolism disorder, oxidative stress, dynamic disorder, mitochondrial DNA mutation, and calcium homeostasis imbalance. The application of traditional Chinese medicine treated myocardial hypertrophy based on mitochondrial dysfunction provided a new theoretical basis and new perspective for the future.

关键词

心肌肥大中药线粒体氧化应激能量代谢综述

Keywords

myocardial hypertrophytraditional Chinese herbal medicine mitochondriaoxidative stressenergy metabolismreview

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