Traditional Chinese medicine research progress of diarrhea predominant irritable bowel syndrome (liver depression and spleen deficiency syndrome)

Yanfang MIAO; Yuxian WANG

doi:10.16305/j.1007-1334.2021.2008055

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Traditional Chinese medicine research progress of diarrhea predominant irritable bowel syndrome (liver depression and spleen deficiency syndrome)

更新时间：2022-08-03

- Traditional Chinese medicine research progress of diarrhea predominant irritable bowel syndrome (liver depression and spleen deficiency syndrome)
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 7, Pages: 91-94(2021)
- 作者机构：
  
  1.首都医科大学附属北京中医医院消化中心（北京　100010）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.2008055
  CLC：
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Yanfang MIAO, Yuxian WANG. Traditional Chinese medicine research progress of diarrhea predominant irritable bowel syndrome (liver depression and spleen deficiency syndrome). [J]. Shanghai Journal of Traditional Chinese Medicine 55(7):91-94(2021)
DOI：

Yanfang MIAO, Yuxian WANG. Traditional Chinese medicine research progress of diarrhea predominant irritable bowel syndrome (liver depression and spleen deficiency syndrome). [J]. Shanghai Journal of Traditional Chinese Medicine 55(7):91-94(2021) DOI： 10.16305/j.1007-1334.2021.2008055.

摘要

腹泻型肠易激综合征（IBS-D）是临床常见的一种肠功能紊乱性疾病，中医病机虽然有肝脾失调、肝旺脾虚、肝郁脾虚之别，但总与肝、脾两脏相关，且以肝郁脾虚最为常见。从病因病机、临床研究、作用机制研究三个方面综述肝郁脾虚型IBS-D的中医研究进展。以痛泻要方为代表，具有调肝理脾功效的中药方剂能很好地改善肝郁脾虚型IBS-D患者的腹痛、腹泻症状及心理、行为状态，进而提高患者的生活质量；在作用机制方面，中医药可能是通过调节脑-肠轴、内脏高敏感及相关离子转运等途径发挥治疗作用。

Abstract

Diarrhea predominant irritable bowel syndrome (IBS-D) is a common intestinal dysfunction disease in clinic. Traditional Chinese medicine (TCM) pathogenesis may vary in different cases, for instance, liver-spleen imbalance, liver hyperactivity and spleen deficiency and liver depression and spleen deficiency, but it is the liver and spleen that are always affected and the most common syndrome is liver depression and spleen deficiency. The TCM research progress of IBS-D (liver depression and spleen deficiency syndrome) was reviewed from three aspects: etiology and pathogenesis, clinical research and mechanism of action. TCM prescription with the effect of regulating liver and spleen, represented by Tongxie Yaofang, can improve symptoms of abdominal pain and diarrhea, psychological and behavioral state of patients with IBS-D of liver depression and spleen deficiency syndrome, and then improve their quality of life. When it comes to the mechanism of action, the therapeutic effects of TCM can be realized by regulating brain-gut axis, visceral hypersensitivity and related ion transport.

关键词

腹泻型肠易激综合征肝郁脾虚证痛泻要方脑-肠轴内脏高敏感综述

Keywords

diarrhea predominant irritable bowel syndromeliver depression and spleen deficiency syndromeTongxie Yaofangbrain-gut axisvisceral hypersensitivityreview

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