Clinical observation of Xiao Chaihu Decoction combined Zhibai Dihuang Decoction in treatment of CKD3-4 period patients

Guanjun PU; Jining GAO

doi:10.16305/j.1007-1334.2021.2008032

您当前的位置：

首页 >

文章列表页 >

Clinical observation of Xiao Chaihu Decoction combined Zhibai Dihuang Decoction in treatment of CKD3-4 period patients

更新时间：2022-08-03

- Clinical observation of Xiao Chaihu Decoction combined Zhibai Dihuang Decoction in treatment of CKD3-4 period patients
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 3, Pages: 54-56,73(2021)
- 作者机构：
  
  1.上海市浦东新区中医医院中医内科（上海　201200）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.2008032
  CLC：
扫描看全文
Guanjun PU, Jining GAO. Clinical observation of Xiao Chaihu Decoction combined Zhibai Dihuang Decoction in treatment of CKD3-4 period patients. [J]. Shanghai Journal of Traditional Chinese Medicine 55(3):54-56,73(2021)
DOI：

Guanjun PU, Jining GAO. Clinical observation of Xiao Chaihu Decoction combined Zhibai Dihuang Decoction in treatment of CKD3-4 period patients. [J]. Shanghai Journal of Traditional Chinese Medicine 55(3):54-56,73(2021) DOI： 10.16305/j.1007-1334.2021.2008032.

摘要

目的,2,观察小柴胡汤合知柏地黄汤治疗慢性肾脏病（CKD）3-4期的临床疗效。,方法,2,将90例CKD3-4期患者随机分为治疗组和对照组，每组45例。对照组给予西医基础治疗，治疗组在对照组基础上加用小柴胡汤合知柏地黄汤。两组疗程均为8周，观察临床疗效以及肾功能指标[血肌酐（Scr）、尿素氮（BUN）、肌酐清除率（Ccr）]、中医证候积分的变化情况。,结果,2,治疗组、对照组总有效率分别为93.33%、66.66%；治疗组临床疗效优于对照组（,P,<,0.05）。两组治疗后Scr、BUN、Ccr、中医证候积分均有改善（,P,<,0.05），治疗组的改善程度均优于对照组（,P,<,0.05）。,结论,2,小柴胡汤合知柏地黄汤可以改善CKD3-4期患者的临床症状、肾功能，临床疗效满意。

Abstract

Objective,2,To observe the clinical efficacy of Xiao Chaihu Decoction combined Zhibai Dihuang Decoction in treatment of CKD3-4 period.,Methods,2,Ninety patients with CKD3-4 period were randomly divided into treatment group and control group,45 patients in each group. All the patients were treated with basic therapy. In addition, the treatment group was given Xiao Chaihu Decoction combined Zhibai Dihuang Decoction. The treatment course was 8 weeks in both group. The clinical efficacy, relevant laboratory indicators (Scr, BUN, Ccr)and TCM syndrome scores were observed.,Results,2,The total effective rate of the treatment group and the control group were 93.33% and 66.66% respectively, and the clinical efficacy of the treatment group was better than that of the control group( ,P,<,0.05). After treatment, the level of Scr, BUN, Ccr, and the TCM syndrome scores were significantly improved in both groups ( ,P,<,0.05) and they were significantly better in the treatment group than those in the control group ( ,P,<,0.05).,Conclusions,2,Xiao Chaihu Decoction combined Zhibai Dihuang Decoction could improve clinical symptoms and renal function of patients with CKD3-4 period. The clinical efficacy was satisfactory.

关键词

慢性肾脏病小柴胡汤知柏地黄汤临床疗效

Keywords

chronic kidney diseaseXiao Chaihu DecoctionZhibai Dihuang Decoctionclinical efficacy

references

K/DOQI. Clinical practice Guidelines for Chronic Kidney Disease: evaluation, classification, and stratification[J]. Am J Kidney Dis, 2002, 39(Sup1): S1-S266.

徐建虎，陈甲秀，张琦，等. 基于2 898则古今医案的数据挖掘探讨小柴胡汤病证规律[J]. 时珍国医国药,2014, 25(8): 2028-2029.

国家药品监督管理局. 中药新药临床研究指导原则（试行）[M].北京：中国医药科技出版社，2002: 164.

张璇，魏科祥，孙娟娟，等. 健脾益肾泄浊饮治疗慢性肾功能衰竭临床研究[J]. 陕西中医,2017, 38(10): 1415-1416.

中华中医药学会肾病分会. 慢性肾衰竭的诊断、辨证分型及疗效评定（试行方案）[J]. 上海中医药杂志,2006, 40(8): 8-9.

王军超. 扶正泄浊保肾汤治疗慢性肾功能衰竭（脾肾阳虚）临床观察[J]. 实用中医内科杂志,2019, 33(7): 58-61.

钱莹，李砚民，陈永强. 海昆肾喜胶囊对慢性肾衰竭患者氧化应激影响的临床观察[J]. 上海中医药杂志,2018, 52(4): 59-61.

冯全生，杨爱东. 温病学[M].3版. 上海：上海科学技术出版社，2019: 203.

阮天红. 小柴胡汤治疗糖尿病肾病慢性肾功能衰竭的临床观察[J]. 中国中医药科技,2014, 21(4): 434-434.

蒲冠军，高继宁. 从少阳、阳明合病辨治慢性肾功能衰竭验案1则[J]. 山西中医,2017, 33(7): 37.

Views

193

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical efficacy of Qiyu Qinghua Decoction on proteinuria in chronic kidney disease of spleen-and-kidney qi deficiency type and its effect on inflammatory cytokines

Research progress in anti⁃tumor clinical efficacy and mechanism of action of Sarcandrae Herba

A randomized， double‑blind， placebo‑controlled clinical trial on the external application of Taohong Siwu Decoction to improve the arteriovenous fistula patency during hemodialysis

Meta-analysis on efficacy and safety of Ginkgo Folium extract in treating diabetic kidney disease

Meta⁃analysis of efficacy and safety of Dachengqi Decoction combined with octreotide and conventional therapy for early postoperative inflammatory small bowel obstruction

Related Author

No data

Related Institution

Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

Department of Nephrology, Minhang Branch of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

Sichuan Institute for Translational Chinese Medicine

Shanghai University of Traditional Chinese Medicine

Department of Nephrology， Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

⁰