Research progress on antitumor components and mechanism of <italic style="font-style: italic">Solanumnigrum</italic> L.

Lei CHEN; Xiao PENG; Bing HU

doi:10.16305/j.1007-1334.2021.2007176

您当前的位置：

首页 >

文章列表页 >

Research progress on antitumor components and mechanism of Solanumnigrum L.

更新时间：2022-08-03

- Research progress on antitumor components and mechanism of Solanumnigrum L.
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 2, Pages: 101-104(2021)
- 作者机构：
  
  1.上海中医药大学附属龙华医院中医肿瘤研究所（上海　200032）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.2007176
  CLC：
扫描看全文
Lei CHEN, Xiao PENG, Bing HU. Research progress on antitumor components and mechanism of Solanumnigrum L.. [J]. Shanghai Journal of Traditional Chinese Medicine 55(2):101-104(2021)
DOI：

Lei CHEN, Xiao PENG, Bing HU. Research progress on antitumor components and mechanism of Solanumnigrum L.. [J]. Shanghai Journal of Traditional Chinese Medicine 55(2):101-104(2021) DOI： 10.16305/j.1007-1334.2021.2007176.

摘要

龙葵是治疗肿瘤的常用中药，含有多种抗肿瘤活性成分，如龙葵碱、澳洲茄边碱、龙葵酸、澳洲茄碱、澳洲茄胺、去半乳糖替告皂苷、槲皮素、薯蓣皂苷元等，可治疗胃癌、肺癌、大肠癌、乳腺癌、膀胱癌、肝癌、骨肉瘤、前列腺癌等恶性肿瘤。其抗肿瘤作用及机制主要包括抑制增殖生长、阻滞细胞周期、诱导细胞凋亡、抑制上皮-间质转化和转移、逆转耐药、增强放化疗和靶向治疗疗效等。

Abstract

Solanumnigrum, L.is a Chinese medicine commonly used in tumor treatment, which contains a variety of anti-tumor active ingredients, such as solanine, solamargine, solaoiacid, solasonine, solasodine, degalactotigonin, quercetin, diosgenin and so on.It can be used to treat gastric cancer, lung cancer, colorectal cancer, breast cancer, bladder cancer, liver cancer, osteosarcoma, prostate cancer and other malignant tumors.Its anti-tumor mechanisms include inhibition of proliferation and growth, arrest of cell cycle, induction of apoptosis, inhibition of epithelial-stromal transformation and metastasis, reversal of drug resistance, enhancement of radiotherapy, chemotherapy and targeted therapy.

关键词

龙葵活性成分抗肿瘤作用作用机制综述

Keywords

Solanumnigrum L.active ingredientsantitumor effectsmechanismreview

references

闫霞，郑佳露，沈克平，等. 龙葵抗肿瘤作用及机制研究[J].世界中西医结合杂志,2017,12(8): 1177-1180.

RU J, LI P, WANG J, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines[J].J Cheminform,2014(6): 13.

姚运香. 龙葵体外抗肿瘤活性部位的筛选及化学成分研究[D].南京：南京农业大学，2009.

赫军，周畅玓，马秉智，等. 龙葵的化学成分及抗肿瘤药理活性研究进展[J].中国药房,2015,26(31): 4433-4436.

闫霞，郑佳露，胡兵. 龙葵碱抗肿瘤作用及机制[J].世界中医药,2017,12(9): 2241-2245.

李明慧，丁岗，孟兆青，等. 龙葵药材中澳洲茄碱、澳洲茄边碱的含量测定[J].中国天然药物,2007,5(5): 360-362.

周新兰，何祥久，周光雄，等. 龙葵全草皂苷类化学成分研究[J].中草药,2006,37(11): 1618-1621.

CHEN R, FENG L, LI H D, et al. Two novel oligosaccharides from Solanum nigrum[J].Carbohydr Res,2009,344(13): 1775-1777.

WU J, TANG X, MA C, et al. The regulation and interaction of colon cancer-associated transcript-1 and miR7-5p contribute to the inhibition of SP1 expression by solamargine in human nasopharyngeal carcinoma cells[J].Phytother Res,2020,34(1): 201-213.

FU R, WANG X, HU Y, et al. Solamargine inhibits gastric cancer progression by regulating the expression of lncNEAT1_2 via the MAPK signaling pathway[J].Int J Oncol,2019,54(5): 1545-1554.

胡兵，安红梅，闫霞，等. 龙葵单体澳洲茄边碱对大肠癌HCT116细胞增殖和凋亡作用[J].中医药学报,2019,47(1): 61-63.

LIU Z, MA C, TANG X, et al. The reciprocal interaction between lncRNA CCAT1 and miR-375-3p contribute to the downregulation of IRF5 gene expression by solasonine in HepG2 human hepatocellular carcinoma cells[J].Front Oncol,2019(9): 1081.

WANG X, ZOU S, LAN Y L, et al. Solasonine inhibits glioma growth through anti-inflammatory pathways[J].Am J Transl Res,2017,9(9): 3977-3989.

SHI F, WANG C, WANG L, et al. Preparative isolation and purification of steroidal glycoalkaloid from the ripe berries of Solanum nigrum L. by preparative HPLC-MS and UHPLC-TOF-MS/MS and its anti-non-small cell lung tumors effects in vitro and in vivo[J].J Sep Sci,2019,42(15): 2471-2481.

NATH L R, GORANTLA J N, THULASIDASAN A K, et al. Evaluation of uttroside B, a saponin from Solanum nigrum Linn, as a promising chemotherapeutic agent against hepatocellular carcinoma[J].Sci Rep,2016(6): 36318.

MAO X M, ZHOU P, LI S Y, et al. Diosgenin suppresses cholangiocarcinoma cells via inducing cell cycle arrest and mitochondria-mediated apoptosis[J].Onco Targets Ther,2019(12): 9093-9104.

LIAO W L, LIN J Y, SHIEH J C, et al. Induction of G2/M phase arrest by diosgenin via activation of Chk1 kinase and Cdc25C regulatory pathways to promote apoptosis in human breast cancer cells[J].Int J Mol Sci,2019,21(1): 172.

PAN B, ZHONG W, DENG Z, et al. Inhibition of prostate cancer growth by solanine requires the suppression of cell cycle proteins and the activation of ROS/P38 signaling pathway[J].Cancer Med,2016,5(11): 3214-3222.

YAN X, LI M, CHEN L, et al. αsolanine inhibits growth and metastatic potential of human colorectal cancer cells[J].Oncol Rep,2020,43(5): 1387-1396.

DING X, ZHU F, YANG Y, et al.Purification, antitumor activity in vitro of steroidal glycoalkaloids from black nightshade （Solanum nigrum L.）[J].Food Chem,2013,141(2): 1181-1186.

PHAM M Q, TRAN T, PHAM Q L, et al. In silico analysis of the binding properties of solasonine to mortalin and p53, and in vitro pharmacological studies of its apoptotic and cytotoxic effects on human HepG2 and Hep3b hepatocellular carcinoma cells[J].Fundam Clin Pharmacol,2019,33(4): 385-396.

ZHANG X, YAN Z, XU T, et al. Solamargine derived from Solanum nigrum induces apoptosis of human cholangiocarcinoma QBC939 cells[J].Oncol Lett,2018,15(5): 6329-6335.

胡兵，安红梅，闫霞，等. 澳洲茄边碱对大肠癌RKO细胞增殖和凋亡作用[J].时珍国医国药,2018,29(8): 1839-1841.

ZHUANG Y W, WU C E, ZHOU J Y, et al. Solasodine reverses stemness and epithelial-mesenchymal transition in human colorectal cancer[J].Biochem Biophys Res Commun,2018,505(2): 485-491.

LU X, CHEN D, YANG F, et al. Quercetin inhibits epithelial-to-mesenchymal transition（EMT）process and promotes apoptosis in prostate cancer via downregulating lncRNA MALAT1[J].Cancer Manag Res,2020(12): 1741-1750.

XIE X, ZHU H, ZHANG J, et al. Solamargine inhibits the migration and invasion of HepG2 cells by blocking epithelial-to-mesenchymal transition[J].Oncol Lett,2017,14(1): 447-452.

LIU S, RONG G, LI X, et al. Diosgenin and GSK126 produce synergistic effects on epithelial-mesenchymal transition in gastric cancer cells by mediating EZH2 via the Rho/ROCK signaling pathway[J].Onco Targets Ther,2020(13): 5057-5067.

HUANG H, NIE C, QIN X, et al. Diosgenin inhibits the epithelial-mesenchymal transition initiation in osteosarcoma cells via the p38MAPK signaling pathway[J].Oncol Lett,2019,18(4): 4278-4287.

CHAFFER C L, WEINBERG R A. A perspective on cancer cell metastasis[J].Science,2011,331(6024): 1559-1564.

ZHAO Z, JIA Q, WU M S, et al. Degalactotigonin, a natural compound from Solanum nigrum L., inhibits growth and metastasis of osteosarcoma through GSK3β inactivation-mediated repression of the Hedgehog/Gli1 pathway[J].Clin Cancer Res,2018,24(1): 130-144.

TUAN ANH H L，TRAN P T，THAO D T，et al. Degalactotigonin, a steroidal glycoside from Solanum nigrum，induces apoptosis and cell cycle arrest via inhibiting the EGFR signaling pathways in pancreatic cancer cells[J/OL].Biomed Res Int, 2018[2020-06-10].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311251/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311251/.

SHEN K H, HUNG J H, CHANG C W, et al. Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression[J].Chem Biol Interact,2017(268): 129-135.

SHEN K H, LIAO A C, HUNG J H, et al. α-Solanine inhibits invasion of human prostate cancer cell by suppressing epithelial-mesenchymal transition and MMPs expression[J].Molecules,2014,19(8): 11896-11914.

SANI I K, MARASHI S H, KALALINIA F. Solamargine inhibits migration and invasion of human hepatocellular carcinoma cells through down-regulation of matrix metalloproteinases 2 and 9 expression and activity[J].Toxicol In Vitro,2015,29(5): 893-900.

SHAHI T P, GUPTA M, SINGH S, et al. Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling[J].BMC Cancer,2020,20(1): 4.

YANG J, HAO T, SUN J, et al. Long noncoding RNA GAS5 modulates α-Solanine-induced radiosensitivity by negatively regulating miR-18a in human prostate cancer cells[J].Biomed Pharmacother,2019(112): 108656.

WU J, WANG L, DU X, et al. α-solanine enhances the chemosensitivity of esophageal cancer cells by inducing microRNA138 expression[J].Oncol Rep,2018,39(3): 1163-1172.

DONG M, MENG Z, KUERBAN K, et al. Diosgenin promotes antitumor immunity and PD-1 antibody efficacy against melanoma by regulating intestinal microbiota[J].Cell Death Dis,2018,9(10): 1039.

YI Y J, JIA X H, WANG J Y, et al. Solanine induced apoptosis and increased chemosensitivity to adriamycin in T-cell acute lymphoblastic leukemia cells[J].Oncol Lett,2018,15(5): 7383-7388.

ZHANG X, HUANG J, YU C, et al. Quercetin enhanced paclitaxel therapeutic effects towards PC-3 prostate cancer through ER stress induction and ROS production[J].Onco Targets Ther,2020(13): 513-523.

NAJAFI M，TAVAKOL S，ZARRABI A，et al. Dual role of quercetin in enhancing the efficacy of cisplatin in chemotherapy and protection against its side effects: a review[J/OL].Arch Physiol Biochem, 2020[2020-06-10]. https://www.tandfonline.com/doi/full/10.1080/13813455.2020.1773864https://www.tandfonline.com/doi/full/10.1080/13813455.2020.1773864.

LI Y, WANG Z, JIN J, et al. Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway[J].Biochem Biophys Res Commun,2020,523(4): 947-953.

WANG Q, CHEN Y, LU H, et al. Quercetin radiosensitizes non-small cell lung cancer cells through the regulation of miR-16-5p/WEE1 axis[J].IUBMB Life,2020,72(5): 1012-1022.

YANG J, HUANG W, TAN W. Solasonine, a natural glycoalkaloid compound, inhibits gli-mediated transcriptional activity[J].Molecules,2016,21(10): 1364.

YI Y J, JIA X H, ZHU C, et al. Solanine reverses multidrug resistance in human myelogenous leukemia K562/ADM cells by downregulating MRP1 expression[J].Oncol Lett,2018,15(6): 10070-10076.

LI X, ZHAO Y, JI M, et al. Induction of actin disruption and downregulation of P-glycoprotein expression by solamargine in multidrug-resistant K562/A02 cells[J].Chin Med J (Engl),2011,124(13): 2038-2044.

PRIETO-VILA M, SHIMOMURA I, KOGURE A, et al. Quercetin inhibits lef1 and resensitizes docetaxel-resistant breast cancer cells[J].Molecules,2020,25(11): 2576.

ZHOU Y, ZHANG J, WANG K, et al. Quercetin overcomes colon cancer cells resistance to chemotherapy by inhibiting solute carrier family 1, member 5 transporter[J].Eur J Pharmacol,2020(881): 173185.

Views

1407

下载量

CSCD

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research progress on active components and mechanism of traditional Chinese herbal medicine for antianxiety

Research progress on mechanisms of platycodin D on non-small cell lung cancer

Advances on effects of ginsenoside Rg₂ and ginsenoside Rh₁ on nervous system and related mechanisms

Research progress on anticancer mechanism of ginger via multi-targets and multi-pathways

Effects of traditional Chinese medicine on cAMP response element binding protein signaling pathway in cognitive impairment

Related Author

No data

Related Institution

College of Pharmacy,Heilongjiang University of Chinese Medicine

Department of Pharmacy, Heilongjiang provincial hospital

Research Center for Traditional Chinese Medicine Complexity System, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine

College of Chinese Medicinal Materials, Jilin Agricultural University

Research and Development Center for New Drugs,Guang’anmen Hospital,China Academy of Chinese Medical Sciences

⁰

Research progress on antitumor components and mechanism of Solanumnigrum L.

DOI：10.16305/j.1007-1334.2021.2007176

摘要

Abstract

关键词

Keywords

references