Clinical observation on Pinggan Huotan Decoction in treating insomnia with hypomnesis of liver depression and phlegm heat syndrome

Yunyu LING; Liang XU

doi:10.16305/j.1007-1334.2021.2007171

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Clinical observation on Pinggan Huotan Decoction in treating insomnia with hypomnesis of liver depression and phlegm heat syndrome

更新时间：2022-08-03

- Clinical observation on Pinggan Huotan Decoction in treating insomnia with hypomnesis of liver depression and phlegm heat syndrome
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 8, Pages: 71-74(2021)
- 作者机构：
  
  1.上海市奉贤区中医医院脑病科（上海　201499）
  2.上海中医药大学附属市中医医院神志病科（上海　200071）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.2007171
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Yunyu LING, Liang XU. Clinical observation on Pinggan Huotan Decoction in treating insomnia with hypomnesis of liver depression and phlegm heat syndrome. [J]. Shanghai Journal of Traditional Chinese Medicine 55(8):71-74(2021)
DOI：

Yunyu LING, Liang XU. Clinical observation on Pinggan Huotan Decoction in treating insomnia with hypomnesis of liver depression and phlegm heat syndrome. [J]. Shanghai Journal of Traditional Chinese Medicine 55(8):71-74(2021) DOI： 10.16305/j.1007-1334.2021.2007171.

摘要

目的,2,观察平肝豁痰方治疗肝郁痰热型不寐伴记忆力减退的临床疗效。,方法,2,将72例肝郁痰热型不寐伴记忆力减退患者随机分为治疗组和对照组，每组36例。对照组予舒肝解郁胶囊治疗，治疗组予平肝豁痰方治疗。两组疗程均为8周，观察临床疗效，比较中医证候积分、改良SPIEGEL自评量表评分、事件相关电位（ERP）检测中P300潜伏期和波幅的变化情况。,结果,2,①试验过程中，对照组脱落3例、治疗组脱落2例，最终完成试验者67例，其中对照组33例、治疗组34例。②治疗组、对照组总有效率分别为88.23%、63.64%，治疗组临床疗效优于对照组（,P,<,0.05）。③随着治疗时间的延长，两组中医证候积分、改良SPIEGEL自评量表评分均逐渐降低（,P,<,0.001）；治疗4周、6周、8周组间比较，治疗组中医证候积分、改良SPIEGEL自评量表评分低于对照组（,P,<,0.05）。④治疗前后组内比较，治疗组P300潜伏期缩短、波幅增大（,P,<,0.05），对照组P300潜伏期缩短（,P,<,0.05）；组间治疗后比较，P300潜伏期及波幅差异有统计学意义（,P,<,0.05）。,结论,2,平肝豁痰方治疗肝郁痰热型不寐伴记忆力减退疗效满意，能显著改善患者的失眠、记忆力减退症状及中医证候。

Abstract

Objective,2,To observe the clinical effect of Pinggan Huotan Decoction on insomnia with hypomnesia of liver depression and phlegm heat syndrome.,Methods,2,Totally 72 patients with insomnia and hypomnesia of liver depression and phlegm heat syndrome were randomly divided into treatment group (,n,=36) and control group (,n,=36). The control group was administered with Shugan Jieyu Capsule, while the treatment group was administered with Pinggan Huotan Decoction. The course of treatment in both groups was 8 weeks. We observed the clinical efficacy, and compared the changes of TCM syndrome scores, modified Spiegel criteria scores, and P300 latency and amplitude in event-related potential (ERP) detection.,Results,2,①During the clinical trial, there were 3 drop-out cases in the control group and 2 drop-out cases in the treatment group, and 67 cases finally completed the trail, including 33 cases in the control group and 34 cases in the treatment group. ②The total effective rates of the treatment group and the control group were 88.23% and 63.64%, respectively. The clinical effect of the treatment group was better than that of the control group (,P,<,0.05). ③With the prolongation of treatment time, TCM syndrome scores and modified Spiegel criteria scores of both groups gradually decreased (,P,<,0.001); According to the inter-group comparison after 4 weeks, 6 weeks and 8 weeks of treatment, the TCM syndrome scores and modified Spiegel criteria scores of the treatment group were lower than those of the control group (,P,<,0.05). ④According to the intra-group comparison before and after treatment, the latency of P300 became shorter and the amplitude increased in the treatment group after treatment (,P,<,0.05), and the latency of P300 became shorter in the control group after treatment (,P,<,0.05); According to the inter-group comparison after treatment, there were significant differences in latency and amplitude of P300 between the two groups (,P,<,0.05).,Conclusion,2,Pinggan Huotan Decoction is effective in treating insomnia with hypomnesis of liver depression and phlegm heat syndrome as it can significantly improve patients’ symptoms of insomnia, hypomnesis and TCM syndromes.

关键词

失眠不寐记忆力减退平肝豁痰方事件相关电位

Keywords

insomniasleeplessnesshypomnesisPinggan Huotan Decoctionevent-related potential

references

梁钢，曾飞剑. 失眠症从肝论治研究进展[J]. 广西中医药大学学报，2019, 22(2): 55-59.

许良，徐建，王惠茹，等. 失眠患者睡眠与觉醒相关因素临床调查研究[J]. 中国中医基础医学杂志，2010, 16(5): 55-59.

American Psychiatric Association. Diagnostic and statistical manual of mental disorders[M]. 5th ed. Arlington VA: American Psychiatric Association, 2013.

贾建平，陈生弟. 神经病学[M]. 北京：人民卫生出版社，2013.

中国中医科学院失眠症中医临床实践指南课题组. 失眠症中医临床实践指南（WHO/WPO）[J]. 世界睡眠医学杂志，2016, 3(1): 8-25.

国家药品监督管理局. 中药新药临床研究指导原则（试行）[M]. 北京：中国医药科技出版社，2002: 156-162.

中华医学会神经病学分会，中华医学会神经病学分会睡眠障碍学组，中华医学会神经病学分会神经心理与行为神经病学学组. 中国成人失眠伴抑郁焦虑诊治专家共识[J]. 中华神经科杂志，2020, 53(8): 564-574.

蔡峥，麦静愔，王菲. 舒肝解郁胶囊治疗伴抑郁状态的老年轻度认知功能障碍疗效观察[J]. 疑难病杂志，2015, 14(5): 458-461.

陈俊逾，陈惠欣，邱作成，等. 舒肝解郁胶囊治疗睡眠障碍33例[J]. 中国中医药现代远程教育，2013, 11(2): 12-13.

王静，胡艳丽. 中西医结合治疗抑郁障碍失眠的疗效观察[J]. 辽宁中医杂志，2015, 42(6): 1275-1277.

周建波，于志军，麦少珍，等. 舒眠胶囊与舒肝解郁胶囊治疗原发性失眠肝气郁结证的随机对照试验[J]. 中国医学创新，2019, 16(19): 120-123.

TAKAHASHI S, UKAI S, KOSE A, et al. Reduction of cortical GABA ergic inhibition correlates with working memory impairment in recent onset schizophnenia[J]. Schizophr Res, 2013, 146(1-3): 238-243.

黄景斌，吴茜，许良，等. 失眠症伴记忆力减退患者事件相关电位P300的特点研究[J]. 上海中医药大学学报，2010, 24(6): 50-53.

许良，黄景斌，吴茜，等. 平肝活血方结合落花安神合剂对失眠症伴记忆力减退患者事件相关电位的影响[J]. 上海中医药杂志，2012, 46(11): 7-8.

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