Effect of self-made Yiqi Jiedu Decoction combined with recombinant human interferon α-2b on the local microecological environment and related immune function indexes in patients with cervical persistent high-risk HPV infection

Minxia KANG; Leilei CUI; Yinjuan HUANG; Bo PENG

doi:10.16305/j.1007-1334.2021.2007026

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Effect of self-made Yiqi Jiedu Decoction combined with recombinant human interferon α-2b on the local microecological environment and related immune function indexes in patients with cervical persistent high-risk HPV infection

更新时间：2022-08-03

- Effect of self-made Yiqi Jiedu Decoction combined with recombinant human interferon α-2b on the local microecological environment and related immune function indexes in patients with cervical persistent high-risk HPV infection
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 11, Pages: 54-58(2021)
- 作者机构：
  
  1.郑州市第七人民医院（河南　郑州　450000）
  2.成都中医药大学附属医院（四川　成都　610072）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.2007026
  CLC：
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Minxia KANG, Leilei CUI, Yinjuan HUANG, et al. Effect of self-made Yiqi Jiedu Decoction combined with recombinant human interferon α-2b on the local microecological environment and related immune function indexes in patients with cervical persistent high-risk HPV infection. [J]. Shanghai Journal of Traditional Chinese Medicine 55(11):54-58(2021)
DOI：

Minxia KANG, Leilei CUI, Yinjuan HUANG, et al. Effect of self-made Yiqi Jiedu Decoction combined with recombinant human interferon α-2b on the local microecological environment and related immune function indexes in patients with cervical persistent high-risk HPV infection. [J]. Shanghai Journal of Traditional Chinese Medicine 55(11):54-58(2021) DOI： 10.16305/j.1007-1334.2021.2007026.

摘要

目的,2,观察自拟益气解毒汤联合重组人干扰素α-2b对宫颈高危型人乳头瘤病毒（HPV）持续感染患者局部微生态环境及相关免疫功能指标的影响。,方法,2,纳入64例宫颈高危型HPV持续感染患者，按照随机数字表分为治疗组和对照组，每组各32 例。对照组患者给予重组人干扰素α-2b阴道泡腾片治疗，治疗组患者在对照组治疗基础上加用自拟益气解毒汤口服。两组疗程均为3个月。比较两组患者的HPV转阴情况；对所有患者的阴道微生态环境指标进行评估，包括阴道分泌物pH值、Nugent评分，比较两组患者的阴道微生态环境复常率；检测宫颈局部干扰素-γ（IFN-γ）以及白介素（IL）-4、IL-12水平。,结果,2,①治疗组患者HPV转阴总有效率为87.5%，对照组为62.5%，治疗组患者的HPV转阴情况优于对照组（,P,<,0.05）。②治疗组患者的阴道微生态环境复常率为84.4%，对照组为46.9%，治疗组患者的阴道微生态环境恢复情况优于对照组（,P,<,0.05）；治疗后，两组患者的阴道分泌物pH值、Nugent评分较治疗前均明显降低（,P,<,0.05），且治疗组患者的阴道分泌物pH值、Nugent评分低于对照组（,P,<,0.05）。③治疗后，两组患者的宫颈局部IFN-γ、IL-12水平较治疗前均明显升高（,P,<,0.05），IL-4水平明显降低（,P,<,0.05），且治疗组患者的IFN-γ、IL-12水平高于对照组（,P,<,0.05），IL-4水平低于对照组（,P,<,0.05）。,结论,2,自拟益气解毒汤联合重组人干扰素α-2b治疗宫颈高危型HPV持续感染，能够有效改善宫颈局部微生态环境，提高HPV转阴率和局部免疫功能。

Abstract

Objective,2,To observe the effect of self-made Yiqi Jiedu Decoction combined with recombinant human interferon α-2b on the local microecological environment and related immune function indexes in patients with cervical persistent high-risk human papilloma virus (HPV) infection., Methods,2,A total of 64 patients with cervical persistent high-risk HPV infection were included and divided into the treatment group and control group according to the random number table, 32 cases in each group. The patients in the control group were treated with recombinant human interferon α-2b vaginal effervescent tablet, and the patients in the treatment group were orally treated with self-made Yiqi Jiedu Decoction based on the treatment of the control group. The treatment course of both groups was three months. The HPV negative change was compared between the two groups; the indexes of vaginal microecological environment were evaluated including the pH value of vaginal secretions and Nugent score, and the recovery rate of vaginal microecological environment was compared; the interferon-γ (IFN-γ), interleukin (IL)-4 and IL-12 levels of cervix were detected.,Results,2,①The total effective rate of HPV negative change was 87.5% in the treatment group and was 62.5% in the control group, and the HPV negative change in the treatment group was better than that in the control group (,P,<,0.05). ②The recovery rate of vaginal microecological environment was 84.4% in the treatment group and was 46.9% in the control group, and the recovery of vaginal microecological environment in the treatment group was better than that in the control group (,P,<,0.05); after treatment, the pH value of vaginal secretions and Nugent score in the two groups were significantly decreased compared with those before treatment (,P,<,0.05), and the pH value of vaginal secretions and Nugent score in the treatment group were lower than those in the control group (,P,<,0.05). ③After treatment, the IFN-γ and IL-12 levels of cervix in the two groups were significantly increased compared with those before treatment, the level of IL-4 was significantly decreased (,P,<,0.05), and the levels of IFN-γ and IL-12 in the treatment group were higher than those in the control group (,P,<,0.05) and the level of IL-4 was lower than that in the control group (,P,<,0.05).,Conclusion,2,Self-made Yiqi Jiedu Decoction combined with recombinant human interferon α-2b can effectively improve the local microecological environment of cervix and enhance the HPV negative rate and local immune function in the treatment of cervical persistent high-risk HPV infection.

关键词

高危型人乳头瘤病毒感染宫颈癌自拟益气解毒汤重组人干扰素α-2b局部微生态环境免疫指标

Keywords

high-risk HPV infectioncervical cancerself-made Yiqi Jiedu Decoctionrecombinant human interferon α-2blocal microecological environmentimmune index

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