A retrospective cohort study on treatment of triple-negative breast cancer with Sanyin Decoction

Ying XIN; Sheng LIU; Yuenong QIN; Chenping SUN

doi:10.16305/j.1007-1334.2021.2007017

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A retrospective cohort study on treatment of triple-negative breast cancer with Sanyin Decoction

更新时间：2022-08-03

- A retrospective cohort study on treatment of triple-negative breast cancer with Sanyin Decoction
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 5, Pages: 63-66(2021)
- 作者机构：
  
  1.上海中医药大学附属龙华医院中西医结合乳腺科（上海　200030）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.2007017
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Ying XIN, Sheng LIU, Yuenong QIN, et al. A retrospective cohort study on treatment of triple-negative breast cancer with Sanyin Decoction. [J]. Shanghai Journal of Traditional Chinese Medicine 55(5):63-66(2021)
DOI：

Ying XIN, Sheng LIU, Yuenong QIN, et al. A retrospective cohort study on treatment of triple-negative breast cancer with Sanyin Decoction. [J]. Shanghai Journal of Traditional Chinese Medicine 55(5):63-66(2021) DOI： 10.16305/j.1007-1334.2021.2007017.

摘要

目的,2,探讨中药三阴方对三阴性乳腺癌患者术后无病生存期的影响。,方法,2,采用回顾性队列研究的方法，纳入三阴性乳腺癌中药暴露组（三阴方参与治疗）患者156例，非暴露组（无三阴方参与治疗）患者192例。比较两组术后6个月、12个月、18个月、24个月的无病生存率，绘制Kaplan-Meier生存曲线，建立Cox回归模型分析影响三阴性乳腺癌术后复发转移的因素。,结果,2,①术后6个月、12个月两组无病生存率差异无统计学意义（,P,>,0.05）；术后18个月中药暴露组、非暴露组的无病生存率分别为98.08%、92.19%，组间差异有统计学意义（,P,<,0.05）；术后24个月中药暴露组、非暴露组的无病生存率分别为98.08%、89.06%，组间差异有统计学意义（,P,<,0.05）。②Cox回归分析结果显示，转移淋巴结分期（,P,<,0.001）、是否有中药干预（,P,<,0.001）是影响三阴性乳腺癌患者术后复发转移的因素，其中中药干预是保护因素[,HR,=0.191（95% ,CI,：0.083～0.443）]，转移淋巴结分期是危险因素，且分级越高复发转移风险越高；发病年龄、病理分级、肿块大小、Ki-67阳性百分比、病理类型及有无接受新辅助化疗与预后无关（,P,>,0.05）。,结论,2,中药三阴方对三阴性乳腺癌有辅助治疗效果，有利于提高患者的无病生存期；转移淋巴结分期是三阴性乳腺癌术后复发转移的危险因素，服用中药三阴方是保护因素。

Abstract

Objective,2,To explore the effect of traditional Chinese medicine (TCM) Sanyin Decoction on postoperative disease-free survival (DFS) of patients with triple-negative breast cancer (TNBC).,Methods,2,A retrospective cohort study was conducted by enrolling 156 TNBC patients in the TCM-exposed group (treatment with Sanyin Decoction involved) and 192 TNBC patients in the non-TCM-exposed group (treatment without Sanyin Decoction involved). The DFS rates at 6 months, 12 months, 18 months and 24 months after operation were compared between the two groups, the survival curve was drawn with the Kaplan-Meier Plotter, and a Cox regression model was established to analyze the factors affecting the recurrence and metastasis of TNBC after operation.,Results,2,①There was no significant difference in the DFS rate between the two groups at 6 months and 12 months after operation (,P,>,0.05). The DFS rates of the TCM-exposed group and the non-TCM-exposed group were 98.08% and 92.19% respectively at 18 months after operation, and the difference between the groups was statistically significant (,P,<,0.05). The DFS rates of the TCM-exposed group and the non-TCM-exposed group were 98.08% and 89.06% respectively at 24 months after operation, and the difference between the two groups was statistically significant (,P,<,0.05). ②The results of Cox regression analysis showed that the staging of metastatic lymph nodes (,P,<,0.001) and TCM intervention (,P,<,0.001) were factors affecting the recurrence and metastasis of TNBC patients after operation, among which TCM intervention was a protective factor [,HR,=0.191 (95% ,CI,: 0.083~0.443) ], the staging of metastatic lymph nodes was a risk factor, and the higher the grade is, the higher the risk of recurrence and metastasis will be. Age of onset, pathological grade, tumor size, percentage of Ki-67-positive cells, pathological type and with/without neoadjuvant chemotherapy were not related to prognosis (,P,>,0.05).,Conclusion,2,Sanyin Decoction has an adjuvant therapeutic effect on TNBC, which is beneficial to the improvement of DFS. The staging of metastatic lymph nodes is a risk factor for postoperative recurrence and metastasis of TNBC, while the intake of Sanyin Decoction is a protective factor.

关键词

三阴性乳腺癌三阴方生存分析队列研究

Keywords

triple-negative breast cancerSanyin Decoctionsurvival analysiscohort study

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Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine

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