Objective,2,To explore the pharmacological mechanism of Fangfeng(,Radix Saposhnikoviae,)-Qinjiao(,Radix Gentianae Macrophyllae,) in the treatment of lumbar disc herniation (LDH) .,Methods,2,The active ingredients and targets of Fangfeng-Qinjiao were screened by Traditional Chinese Medicine System Pharmacology Datebase(TCMSP), and the obtained target protein names were converted into Gene Symbol by Uniprot database; the targets of LDH were searched and screened from GeneCards and OMIM database; the common targets of drug-disease were screened by R software and Venn diagram was drawn. Cytoscape 3.7.0 software was used to construct drug and disease active ingredient-target network map; String database was used to construct protein interaction network of the target and corresponding analysis was performed with R3.6.3 software; GO functional analysis and KEGG pathway enrichment analysis of drug core targets were performed with the "clusterProfiler" R software package, and the results were visualized by R software.,Results,2,Twenty active ingredients of the herb pair and 19 targets of drug-diseases were obtained through screening.The commonly used TCM ingredients were wogonin, beta-sitosterol, 5-O-Methylvisamminol and the key targets were PTGS2, NOS2, AR and ESR1 through drug-disease component target network diagram.The common target PPI network obtained five potential targets with degree values ≥16, which including IL-6, AKT1, CASP3, CXCL8 and PTGS2; A total of 811 enriched items were obtained by GO analysis, including 771 items of biological process, 33 items of molecular function and 7 items of cell component(,P,<,0.05); 39 pathways including IL-17 signaling pathway, TNF pathway, AGE-RAGE signaling pathway were obtained by KEGG analysis(,P,<,0.05).,Conclusion,2,Fangfeng-Qinjiao may exert anti-inflammatory, anti-oxidative stress, anti-apoptosis and regulate immunity through multi-component, multi-target and multi-pathway pathway, thus playing a role in the treatment of LDH.