Meta analysis of therapeutic efficacy and safety of Buyang Huanwu Decoction in prevention and treatment of deep venous thrombosis after orthopaedic surgery

Peng HUANG; Xiangqi MENG; Chenxi WU; Jiajun KONG; Hong ZHU; Fengfeng ZHONG; Nan WANG

doi:10.16305/j.1007-1334.2021.2002091

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Meta analysis of therapeutic efficacy and safety of Buyang Huanwu Decoction in prevention and treatment of deep venous thrombosis after orthopaedic surgery

更新时间：2022-08-03

- Meta analysis of therapeutic efficacy and safety of Buyang Huanwu Decoction in prevention and treatment of deep venous thrombosis after orthopaedic surgery
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 12, Pages: 23-30(2021)
- 作者机构：
  
  1.浙江省长兴县中医院骨科（浙江　长兴　313100）
  2.南京中医药大学附属苏州市中医医院骨科（江苏　苏州　215001）
  3.南京中医药大学附属中西医结合医院骨科（江苏　南京　210028）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.2002091
  CLC：
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Peng HUANG, Xiangqi MENG, Chenxi WU, et al. Meta analysis of therapeutic efficacy and safety of Buyang Huanwu Decoction in prevention and treatment of deep venous thrombosis after orthopaedic surgery. [J]. Shanghai Journal of Traditional Chinese Medicine 55(12):23-30(2021)
DOI：

Peng HUANG, Xiangqi MENG, Chenxi WU, et al. Meta analysis of therapeutic efficacy and safety of Buyang Huanwu Decoction in prevention and treatment of deep venous thrombosis after orthopaedic surgery. [J]. Shanghai Journal of Traditional Chinese Medicine 55(12):23-30(2021) DOI： 10.16305/j.1007-1334.2021.2002091.

摘要

目的,2,通过Meta分析系统评价补阳还五汤防治骨科大手术后深静脉血栓的有效性及安全性。,方法,2,系统检索 CNKI、 WANFANG DATA、 VIP、 SinoMed、 EMbase、 PubMed、 Cochrane Library等数据库，按照预先设定纳入与排除标准筛选随机对照临床试验，应用偏倚风险评估工具进行研究质量评价，提取数据并运用Revman 5.3软件进行Meta分析。,结果,2,共检索到102篇文献，纳入13个研究，总样本数为1 280例，试验组和对照组各640 例。补阳还五汤防治骨科大手术后深静脉血栓，与对照组单用西医抗凝治疗相比，能提高总有效率[OR=4.25,95% ,CI,(2.86,6.30)，,P,<,0.000 01]，降低 D-二聚体[SMD=－2.95,95% ,CI,(－4.66,－1.23),P,<,0.000 01]、凝血酶原时间（PT）[MD=－1.71,95% ,CI,(－3.24,－0.17),P,=0.03]以及纤维蛋白原水平[MD=－0.42,95% ,CI,(－0.72,－0.12),P,=0.006]，减少引流量[MD=－96.84,95% ,CI,(－123.09,－70.59),P,<,0.000 01]，但活化部分凝血活酶时间（APTT）及血液黏度（PV）差异无统计学意义（,P,>,0.05），不良反应较轻微。,结论,2,补阳还五汤防治骨科大手术后深静脉血栓，疗效优于单用西医治疗，但研究结论仍有待更多高质量随机对照试验加以验证。

Abstract

Objective,2,To systematically evaluate the efficacy and safety of Buyang Huanwu Decoction in the prevention and treatment of deep veinous thrombosis after major orthopedic surgery by Meta-analysis.,Methods,2,Databases including CNKI, WANFANG DATA, VIP, SinoMed, EMbase, PubMed and The Cochrane Library and other databases were systematically retrieved. Randomized controlled clinical trials were screened according to pre-set inclusion and exclusion criteria. Risk assessment tools were used to evaluate the quality of the study. Data were extracted and Meta analysis was carried out with Revman 5.3 software.,Results,2,A total of 102 articles were retrieved and 13 studies were included, with a total sample of 1 280 cases, including 640 cases in the experimental group and 640 cases in the control group. Buyang Huanwu Decoction could prevent and treat deep venous thrombosis after major orthopedic surgery. Compared with the control group treated with Western medicine alone, Buyang Huanwu Decoction could increase the overall efficiency [OR=4.25, 95% ,CI,(2.86, 6.30),P,<,0.000 01], reduce D-dimer [SMD=-2.95, 95% ,CI,(-4.66, -1.23),P,<,0.000 01], PT[MD= -1.71, 95% ,CI,(-3.24, -0.17),P,=0.03] and fibrinogen [MD=-0.42, 95% ,CI,(-0.72, -0.12),P,=0.006]. It could also decrease drainage volume[MD=-96.84, 95% ,CI,(-123.09, -70.59),P,<,0.000 01]. However, there was no statistically significant difference in activated partial thromboplastin time(APTT) and blood viscosity(PV)(,P,>,0.05). Adverse reactions were mild.,Conclusion,2,Buyang Huanwu Decoction is more effective than Western medicine in preventing and treating deep venous thrombosis after major orthopedic surgery. However, the conclusion of the study still needs to be verified by more high-quality randomized controlled trials.

关键词

骨科大手术后深静脉血栓补阳还五汤Meta分析

Keywords

deep venous thrombosis after major orthopedic surgeryBuyang Huanwu DecoctionMeta analysis

references

中华医学会外科学分会血管外科学组. 深静脉血栓形成的诊断和治疗指南(第二版)[J]. 中国血管外科杂志（电子版），2013, 5(1): 23-26.

李春会，李惠玲，邹叶芳，等. 中老年髋膝关节置换术后患者下肢深静脉血栓的综合干预策略研究[J]. 中华护理杂志，2015, 50(5): 532-536.

余芳，李志华，付霞丽，等. 补阳还五汤联合利伐沙班预防髋部周围骨折术后深静脉血栓形成的疗效分析[J]. 四川中医，2018, 36(2): 140-142.

中华医学会骨科学分会. 中国骨科大手术静脉血栓栓塞症预防指南[J]. 中华关节外科杂志(电子版)， 2009, 3(3): 380 -383.

陈日勇. 中西医结合在预防股骨转子间骨折术后深静脉血栓形成中的应用研究[J]. 中华中医药学刊，2015, 33(3): 729-731.

郭宏军，李玉民，党熙亮. 加味补阳还五汤和低分子肝素钠预防全髋关节置换术后下肢深静脉血栓形成的作用研究[J]. 解放军医药杂志，2019, 31(2): 94-97.

吴家利，洪汉刚，卢勇，等. 补阳还五汤防治关节置换术后下肢深静脉血栓形成的疗效研究[J]. 中国中医骨伤科杂志，2008, 16(1): 19-22.

马艳. 补阳还五汤联合低分子肝素对股骨转子间骨折术后深静脉血栓形成的影响[J]. 北方药学，2019, 16(7): 99-100.

王荣茂，郭元兵，石树培，等. 加味补阳还五汤预防膝关节置换术后深静脉血栓的研究[J]. 中国中医骨伤科杂志，2010, 18(8): 16-18,21.

张青元. 补阳还五汤对髋关节置换术后气虚血瘀证患者血栓前状态的影响[J]. 光明中医，2019, 34(10): 1516-1517.

包杭生，李逸群，高峻青. 补阳还五汤联合低分子肝素对股骨转子间骨折术后凝血-纤溶系统的影响[J]. 中国中医骨伤科杂志，2014, 22(1): 28-31.

杜明昌，柳椰，翟良全，等. 加味补阳还五汤联合速碧林预防人工全髋关节置换术后下肢深静脉血栓形成作用研究[J]. 辽宁中医药大学学报，2018, 20(7): 198-200.

周玮. 补阳还五汤治疗骨科术后深静脉血栓63例[J]. 西部中医药，2018, 27(8): 77-78.

段明明，周煜虎. 补阳还五汤联合利伐沙班预防髋部周围骨折术后深静脉血栓形成效果观察[J]. 现代中西医结合杂志，2018, 27(19): 2077-2079, 2083.

刘堂正，李其周. 补阳还五汤治疗骨科手术后深静脉血栓[J]. 吉林中医药，2017(37): 49-51.

董昌海，梁发树，李茂瑞. 补阳还五汤防治骨科术后下肢静脉血栓形成[J]. 光明中医，2016, 31(21): 3148-3149.

马松涛，邱庆虎，王科，等. 补阳还五汤加减口服对髋关节置换术后气虚血瘀证患者血栓前状态的影响[J]. 中国中医骨伤科杂志，2018, 26(4): 36-39.

时钦，范涛，杨继兵，等. 红花黄色素对急性脑梗死患者血液流变学影响的Meta分析[J]. 上海中医药杂志，2016, 50(9): 18-19.

王丽亮，金津，杨洋，等. 利伐沙班对比低分子肝素预防髋骨骨折患者发生静脉血栓的有效性和安全性的Meta分析[J]. 中国药房，2019, 30(1): 120-124.

曾宪涛，田国祥，张超，等. Meta分析系列之十五：Meta分析的进展与思考[J]. 中国循证心血管医学杂志，2013, 5(6): 561-563.

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