1.上海中医药大学交叉科学研究院(上海 201203)
2.上海中医药大学上海中医健康服务协同创新中心(上海 201203)
扫 描 看 全 文
Rujing CHEN, Yunjie WU, Kaili HU. Research progress on pharmacological effects of silibinin. [J]. Shanghai Journal of Traditional Chinese Medicine 55(2):90-96(2021)
Rujing CHEN, Yunjie WU, Kaili HU. Research progress on pharmacological effects of silibinin. [J]. Shanghai Journal of Traditional Chinese Medicine 55(2):90-96(2021) DOI: 10.16305/j.1007-1334.2021.2001154.
综述水飞蓟宾药理作用研究进展。研究证实,水飞蓟宾具有抗肿瘤、保肝、护心、抑菌等多种药理活性;其可通过调控激酶、转录因子和细胞信号通路等多个环节抑制癌细胞生长,对肝癌、胃癌、肺癌、乳腺癌、卵巢癌、前列腺癌等均具有显著的抑制作用,具有良好的临床应用前景。
Research progress on pharmacological effects of silibinin is reviewed.Studies have confirmed that silibinin has various pharmacological activities, such as anti-tumor, liver protection, heart protection, antibiosis, etc.Silibinin has a good clinical application prospect, which can inhibit the growth of cancer cells through regulating kinase, transcription factors and cell signaling pathways, thereby showing significant inhibitory effects on liver cancer, gastric cancer, lung cancer, breast cancer, ovarian cancer, prostate cancer and so on. It has good prospect in clinical application.
水飞蓟宾药理活性抗肿瘤综述
silibininpharmacological activitiesanti-tumorreview
马星海.水飞蓟化学成分和药理作用研究进展[J].亚太传统医药,2015,11(19): 62-65.
WEI Q, HE W, LU Y, et al.Effect of the tumor suppressor gene ING4 on the proliferation of MCF-7 human breast cancer cells[J].Oncol Lett,2012,4(3): 438-442.
周大勇,还勇为.水飞蓟宾抑制乳腺癌细胞增殖和促进其凋亡的作用及机制[J].现代肿瘤医学,2016,24(6): 882-885.
ZHENG N, LIU L, LIU W, et al.ERbeta up-regulation was involved in silibinin-induced growth inhibition of human breast cancer MCF-7 cells[J].Arch Biochem Biophys,2016(591): 141-149.
ZHENG N, ZHANG P, HUANG H, et al.ERalpha down-regulation plays a key role in silibinin-induced autophagy and apoptosis in human breast cancer MCF-7 cells[J].J Pharmacol Sci,2015,128(3): 97-107.
ZHENG N, LIU L, LIU W W, et al.Crosstalk of ROS/RNS and autophagy in silibinin-induced apoptosis of MCF-7 human breast cancer cells in vitro[J].Acta Pharmacol Sin,2017,38(2): 277-289.
ZADEH M M, MOTAMED N, RANJI N, et al.Silibinin-induced apoptosis and downregulation of microRNA-21 and microRNA-155 in mcf-7 human breast cancer cells[J].J Breast Cancer,2016,19(1): 45-52.
HOSSAINZADEH S, RANJI N, NADERI S A, et al.Silibinin encapsulation in polymersome: A promising anticancer nanoparticle for inducing apoptosis and decreasing the expression level of miR-125b/miR-182 in human breast cancer cells[J].J Cell Physiol,2019,234(12): 22285-22298.
YAZDI R S E, MOGHASSEMI S, MAHARAT Z, et al.Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line[J].Artif Cell Nanomed B,2018,46(3): 524-535.
FANG X, CHEN J, WANG W, et al.Matrix metalloproteinase 9 (MMP9)level and MMP9 -1562C>T in patients with obstructive sleep apnea: a systematic review and meta-analysis of case-control studies[J].Sleep Med,2020(67): 110-119.
林峰,佟鑫,陈志杭.水飞蓟宾体外抑制MCF-7细胞的增殖和TGF-β诱导的侵袭转移[J].中国现代医生,2015,53(17): 1-3.
车佳.水飞蓟宾通过降低MEK/ERK途径依赖的MMP-9蛋白表达抑制人乳腺癌细胞生长和侵袭转移机制的实验研究[J].浙江中西医结合杂志,2015,25(4): 337-340.
SI L, LIU W, HAYASHI T, et al.Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment[J].Arch Biochem Biophys,2019(671): 42-51.
BARTH J M, KOHLER K.How to take autophagy and endocytosis up a notch[J].Biomed Res Int,2014(2014): 960803.
GUSTAFSSON A B.Bnip3 as a dual regulator of mitochondrial turnover and cell death in the myocardium[J].Pediatr Cardiol,2011,32(3): 267-274.
宣丽杨,金鑫,孟冠敏.水飞蓟宾体外对人肝癌细胞株HepG2蛋白表达的影响及临床意义[J].浙江实用医学,2014,19(6): 400-402.
陈惠云,王少珍,廖联明.水飞蓟宾对人肝癌HepG2细胞迁移的作用研究[J].中华细胞与干细胞杂志(电子版),2016,6(6): 345-350.
RATSIMANDRESY R A, INDRAMOHAN M, DORFLEUTNER A, et al.The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway[J].Cell Mol Immunol,2017,14(1): 127-142.
王金彩,王淑雨,刘小红,等.水飞蓟宾调控STAT3信号通路对肝癌细胞增殖和侵袭的影响[J].癌症进展,2018,16(14): 1746-1749.
MAO J, YANG H, CUI T, et al.Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/Akt[J].Eur J Pharmacol,2018(832): 39-49.
田翀,高青.水飞蓟宾对胃癌细胞BGC-823周期停滞的诱导作用及机制探讨[J].中国临床药理学杂志,2019,35(20): 2605-2608.
伍友兴,桂若虎,郑新平,等.水飞蓟宾抑制缺氧状态下胃癌细胞mTOR磷酸化及HIF-1α表达[J].中国肿瘤生物治疗杂志,2016,23(1): 52-56.
伍友兴,桂若虎,郑新平,等.水飞蓟宾抑制缺氧状态下胃癌细胞系MGC803增殖的分子机制[J].中外医疗,2016,35(11): 9-11.
王阳,李昌林.水飞蓟宾联合5-FU对胃癌细胞株MGC803恶性生物学行为的抑制作用研究[J].海南医学院学报,2016,22(9): 845-848.
DALEY D, ZAMBIRINIS C P, SEIFERT L, et al.Gammadelta T Cells support pancreatic oncogenesis by restraining alphabeta T cell activation[J].Cell,2016,166(6): 1485-1499.
杜玉林,王营,刘军权,等.水飞蓟宾对γδT细胞杀伤胃癌细胞SGC-7901的影响及其机制初探[J].现代免疫学,2015,35(4): 289-293.
吕小婷,刘军权,陈复兴,等.水飞蓟宾增强人CIK细胞杀伤胃癌细胞株BCG-823的体外研究[J].现代免疫学,2017,37(1): 7-13.
高歌,范义增,淡炜超,等.水飞蓟宾对前列腺癌细胞增殖、凋亡的影响及其作用机制[J].现代泌尿外科杂志,2018,23(10): 780-784.
DEEP G, KUMAR R, NAMBIAR D K, et al.Silibinin inhibits hypoxia-induced HIF-1α-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics[J].Mol Carcinogen,2017,56(3): 833-848.
MAHIRA S, KOMMINENI N, HUSAIN G M, et al.Cabazitaxel and silibinin co-encapsulated cationic liposomes for CD44 targeted delivery: A new insight into nanomedicine based combinational chemotherapy for prostate cancer[J].Biomed Pharmacother,2019(110): 803-817.
宋晶晶.水飞蓟宾体外抑制人结肠癌细胞SW480生长和TGF-β诱导的侵袭转移[J].浙江实用医学,2015,20(1): 24-27.
郑荣娟,曹海龙,马嘉珩,等.水飞蓟宾抑制小鼠结肠炎相关肠癌发生机制研究[J].中华肿瘤防治杂志,2018,25(17): 1217-1221.
张慧瑛,罗光宏,张圆圆,等.水飞蓟宾体外诱导人肺癌A549细胞凋亡作用研究[J].中药药理与临床,2016,32(6): 78-81.
YIN K, CUI Y, SUN T, et al.Antagonistic effect of selenium on lead-induced neutrophil apoptosis in chickens via miR-16-5p targeting of PiK3R1 and IGF1R[J].Chemosphere,2020(246): 125794.
毛晓敏.水飞蓟宾联合顺铂诱导人肺腺癌细胞A549凋亡及机制[J].浙江中西医结合杂志,2015,25(3): 242-245.
MATULONIS U A.Highlights in ovarian cancer from the 2017 American society of clinical oncology annual meeting: commentary[J].Clin Adv Hematol Oncol,2017,15 Suppl 7(8): 13-17.
刘磊,胡春杰,李志杰,等.水飞蓟宾诱导卵巢癌HO-8910细胞凋亡增殖及其机制探讨[J].现代生物医学进展,2017,17(20): 3811-3815.
YANG Z, PAN Q, ZHANG D, et al.Silibinin restores the sensitivity of cisplatin and taxol in A2780-resistant cell and reduces drug-induced hepatotoxicity[J].Cancer Manag Res,2019(11): 7111-7122.
MA Z, LIU W, ZENG J, et al.Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma[J].Oncology Reports,2015,34(5): 2461-2468.
LI F, MA Z, GUAN Z, et al.Autophagy induction by silibinin positively contributes to its anti-metastatic capacity via AMPK/mTOR pathway in renal cell carcinoma[J].Int J Mol Sci,2015,16(4): 8415-8429.
范义增,淡炜超,白欣姗,等.水飞蓟宾通过Wnt/β-catenin通路抑制肾癌细胞干细胞特性[J].现代泌尿外科杂志,2018,23(6): 454-459.
王莉,张晓凯,张鹏,等.水飞蓟宾通过上调P15INK4B和P21WAF1/CIP1活化JNK诱导人胰腺癌细胞G1期阻滞及细胞凋亡[J].暨南大学学报(自然科学与医学版),2015,36(1): 21-28.
ZHANG X, LIU J, ZHANG P, et al.Silibinin induces G1 arrest, apoptosis and JNK/SAPK upregulation in SW1990 human pancreatic cancer cells[J].Oncology Letters,2018,15(6): 9868-9876.
邵东珍.阿托伐他汀钙联合水飞蓟宾治疗非酒精性脂肪肝临床效果观察[J].河南医学研究,2018,27(15): 2777-2778.
杨兴平,蒋丽琳.茵栀黄颗粒联合水飞蓟宾胶囊治疗酒精性肝病的疗效观察[J].现代药物与临床,2019,34(3): 701-704.
黄家明.水飞蓟宾对肝星状细胞增殖的抑制和促凋亡作用[J].临床合理用药杂志,2017,10(33): 83-84.
李伟甲.水飞蓟宾对酒精诱导肝纤维化小鼠的保护作用[J].黑龙江医药,2018,31(4): 751-754.
SALOMONE F, BARBAGALLO I, GODOS J, et al.Silibinin restores NAD+levels and induces the SIRT1/AMPK pathway in non-alcoholic fatty liver[J].Nutrients,2017,9(10): 1086.
OU Q, WENG Y, WANG S, et al.Silybin alleviates hepatic steatosis and fibrosis in NASH mice by inhibiting oxidative stress and involvement with the NF-kappaB pathway[J].Dig Dis Sci,2018,63(12): 3398-3408.
SAHLMAN P, NISSINEN M, PUKKALA E, et al.Incidence, survival and cause-specific mortality in alcoholic liver disease: a population-based cohort study[J].Scand J Gastroenterol,2016,51(8): 961-966.
李光明,李万平,李晓冰,等.水飞蓟宾和卡托普利联合用药对大鼠酒精性肝病作用及机制的研究[J].安徽医科大学学报,2019,54(2): 276-280.
武艳强,王慧娟,冯社军,等.水飞蓟宾对H_2O_2诱导大鼠H9C2心肌细胞氧化应激损伤的保护作用[J].现代药物与临床,2015,30(5): 503-508.
曹旭丹,任春梅,和田田,等.水飞蓟宾对离体心脏组织缺血再灌注损伤保护作用及机制研究[J].天津中医药,2019,36(1): 67-70.
陈旭,王晓武,江丽青,等.水飞蓟宾对内毒素血症心肌损伤的保护作用及机制[J].天津医药,2019,47(8): 794-799.
杜文静,谢亚斌,葛雅琨,等.水飞蓟宾对金黄色葡萄球菌和大肠杆菌的体外抑菌作用的研究[J].吉林化工学院学报,2016,33(7): 66-69.
谢思露,赵茂吉,杨朝国.水飞蓟宾对表皮葡萄球菌的抑菌机制研究[J].中药药理与临床,2018,34(6): 58-64.
WANG D, XIE K, ZOU D, et al.Inhibitory effects of silybin on the efflux pump of methicillin-resistant Staphylococcus aureus[J].Mol Med Rep,2018,18(1): 827-833.
SHEN L, LIU L, LI X, et al.Regulation of gut microbiota in Alzheimer’s disease mice by silibinin and silymarin and their pharmacological implications[J].Appl Microbiol Biot,2019,103(17): 7141-7149.
张秀侠.水飞蓟宾对局灶性脑缺血再灌注损伤大鼠保护作用的研究[J].安徽医药,2016,20(3): 445-449.
ZHANG T, KAWAGUCHI N, YOSHIHARA K, et al.Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia[J].Resp Res,2019,20(1): 79.
陈皖晴,张博,曹亚娟,等.髓源抑制细胞介导肿瘤免疫微环境重塑及靶向治疗的研究进展[J].上海中医药杂志,2019,53(11): 92-97.
0
Views
1624
下载量
0
CSCD
25
CNKI被引量
Publicity Resources
Related Articles
Related Author
Related Institution