Objective,2,To observe the clinical efficacy of Shengyang Tongdu acupuncture combined with electromyographic (EMG) biofeedback training in the treatment of cerebral infarction and its effect on patients’ electroencephalography (EEG) topography, neurovascular unit function and heart rate variability (HRV).,Methods,2,Ninety patients with cerebral infarction were randomly divided into a treatment group (,n,=45) and a control group (,n,=45). Both groups underwent basic neurological treatment, while the control group was additionally given EMG biofeedback training and the treatment group was additionally given Shengyang Tongdu acupuncture treatment and EMG biofeedback training. The treatment course was 4 weeks in both groups. The safety of the treatment measures was assessed, and the changes in the stroke related scale scores, traditional Chinese medicine (TCM) syndrome scores, heart rate variability related indexes, EEG topography related indexes and neurovascular unit function related indexes were compared., Results,2,①Finally 83 cases completed the trial, 42 cases in the treatment group and 41 cases in the control group. ②After treatment, the improvement of National Institutes of Health Stroke Scale (NIHSS) score, Fugl-Meyer score, and Bartherl index in the treatment group was significantly better than that in the control group (,P,<,0.05). ③After treatment, the standard deviation of all normal to normal NN intervals (SDNN), the square root of the mean of the squares of successive NN interval differences (RMSSD) and the percentage of NN intervals ,>,50 ms different from preceding interval (PNN50) of heart rate, and the levels of serum matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) in the treatment group were significantly higher than those in the control group (,P,<,0.05); the improvement of power voltage in the beta (β), delta (δ) and theta (θ) bands of the brain in the treatment group were significantly better than those in the control group (,P,<,0.05). ④After treatment, the TCM syndrome scores were significantly lower in both groups (,P,<,0.05); the difference of TCM syndrome scores before and after treatment in the treatment group was significantly higher than that in the control group (,P,<,0.05). ⑤No case of serious adverse reactions was found in both groups.,Conclusion,2,Shengyang Tongdu acupuncture with EMG biofeedback training for cerebral infarction can significantly alleviate clinical symptoms, promote the recovery of nerve function and improve patients’ ability of life, and the mechanism may be related to the improvement of brain electrophysiological activity, neurovascular unit function and autonomic nervous system function.