Yangqing BIAN, Yu ZHENG, Peiyong ZHENG, et al. Meta-analysis of correlation between TCM constitution and colorectal polyps. [J]. Shanghai Journal of Traditional Chinese Medicine 55(2):24-32(2021)
DOI:
Yangqing BIAN, Yu ZHENG, Peiyong ZHENG, et al. Meta-analysis of correlation between TCM constitution and colorectal polyps. [J]. Shanghai Journal of Traditional Chinese Medicine 55(2):24-32(2021) DOI: 10.16305/j.1007-1334.2021.1912017.
Meta-analysis of correlation between TCM constitution and colorectal polyps
Objective,2,To explore the correlation between colorectal polyps and patient’s TCM constitution types for the purpose of providing evidence-based medical basis for prevention and treatment of colorectal polyps.,Methods,2,The clinical research literature on the correlation between TCM constitution types and colorectal polyps were retrieved from China National Knowledge Infrastructure (CNKI), Chongqing VIP fulltext periodical database (VIP), Wanfang data, China Biomedical Literature Database, PubMed, EMBASE, Cochrane Library from the beginning of database establishment to 2018. Based on the inclusion and exclusion criteria, the literatures that finally met the inclusion criteria were manually screened out, and the valid data were extracted. The American Health Care Quality and Research Institute (AHRQ) Cross-Sectional (Prevalence) Study Quality Checklist was applied to evaluate the quality of the literatures, and the relevant literatures were meta-analyzed by R software and Review Manager 5.3 software.,Results,2,①Finally 16 articles included were all cross-sectional studies, of which the sample size of colorectal polyps reached 2,341. ②Among patients with colorectal non-adenomatous polyps included in 7 studies, the number of patients with damp-heat constitution, qi-deficiency constitution, yang-deficiency constitution and phlegm-dampness constitution accounted for a higher proportion of the total number, all exceeding 10%. Among patients with colorectal non-adenomatous polyps included in 13 studies, the number of patients with phlegm-damp constitution, damp-heat constitution, yang-deficiency constitution and qi-deficiency constitution accounted for a higher proportion of the total number, all exceeding 10%. ③There were 4 studies that compared the constitution types of patients with and without adenomatous polyps, involving 678 cases. After data integration and analysis, it was found that the odds ratio (OR) value of adenomatous polyp risk was relatively higher in patients with damp-heat constitution, phlegm-dampness constitution, yang-deficiency constitution and yin-deficiency constitution respectively, and the adenomatous polyp risk was significantly higher than the non-adenomatous polyp risk in patients with phlegm-dampness constitution and yang-deficiency constitution. ④A total of 3 studies compared the constitution types of patients with progressive adenomatous polyps and of those with non-progressive adenomatous polyps, involving 345 cases. After data integration and analysis, it was found that the OR values of the risk of progressive adenoma polyp risk was relatively higher in patients with damp-heat constitution, phlegm-dampness constitution, yang-deficiency constitution, qi-deficiency constitution, yin-deficiency constitution, allergic constitution and mild constitution, and the progressive adenoma polyp risk was significantly higher than the non-progressive adenoma polyp in patients with phlegm-dampness constitution and qi-deficiency constitution. ⑤AHRQ Cross-Sectional (Prevalence) Study Quality Checklist was used to evaluate the methodological quality of the 16 studies included. It was found that the overall quality of literatures included was relatively low and there was a relatively high risk of bias.,Conclusion,2,Damp-heat constitution, phlegm-dampness constitution, yang-deficiency constitution and qi-deficiency constitution are the main constitution types of patients with colorectal polyps (including adenomatous polyps), of which yang-deficiency constitution and phlegm-dampness constitution are the primary risk factors for the onset of colorectal adenomatous polyps, while phlegm-dampness constitution and qi-deficiency constitution are the primary risk factors for the onset of progressive adenomatous polyps.
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