Influence of Cai’s menstruation periodic treatment on lipid metabolism and levels of serum leptin and adiponectin in obese patients with polycystic ovary syndrome

Huayun XU; Shilu KONG; Jinrong FU; Guozeng WANG

doi:10.16305/j.1007-1334.2021.1912011

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Influence of Cai’s menstruation periodic treatment on lipid metabolism and levels of serum leptin and adiponectin in obese patients with polycystic ovary syndrome

更新时间：2022-08-03

- Influence of Cai’s menstruation periodic treatment on lipid metabolism and levels of serum leptin and adiponectin in obese patients with polycystic ovary syndrome
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 7, Pages: 50-54(2021)
- 作者机构：
  
  1.上海市第一人民医院中医科（上海　200080）
  2.上海中医药大学龙华临床医学院（上海　200032）
  3.上海中医药大学附属龙华医院妇科（上海　200032）
  4.同济大学附属东方医院妇产科（上海　200120）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.1912011
  CLC：
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Huayun XU, Shilu KONG, Jinrong FU, et al. Influence of Cai’s menstruation periodic treatment on lipid metabolism and levels of serum leptin and adiponectin in obese patients with polycystic ovary syndrome. [J]. Shanghai Journal of Traditional Chinese Medicine 55(7):50-54(2021)
DOI：

Huayun XU, Shilu KONG, Jinrong FU, et al. Influence of Cai’s menstruation periodic treatment on lipid metabolism and levels of serum leptin and adiponectin in obese patients with polycystic ovary syndrome. [J]. Shanghai Journal of Traditional Chinese Medicine 55(7):50-54(2021) DOI： 10.16305/j.1007-1334.2021.1912011.

摘要

目的,2,观察蔡氏调周法对肥胖型多囊卵巢综合征（PCOS）患者脂代谢及血清瘦素（LEP）、脂联素（ADP）水平的影响。,方法,2,纳入67例肥胖型PCOS患者，随机分为治疗组33例和对照组34例。治疗组给予蔡氏调周法治疗，对照组给予二甲双胍片口服，两组治疗周期均为3个月。治疗前后，计算并比较两组患者的腰臀比（WHR）、体质量指数（BMI）；检测两组患者的脂代谢相关指标水平，包括三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、游离脂肪酸（FFA）及LEP、ADP的水平；检测两组患者的血清黄体生成素（LH）、卵泡刺激素（FSH）、睾酮（T）水平，计算LH/FSH比值。,结果,2,①治疗后，两组患者的TC、LDL水平较治疗前均降低（,P,<,0.05），但组间比较差异无统计学意义（,P,>,0.05）。②治疗后，两组患者的LEP水平均降低（,P,<,0.05）、ADP水平均升高（,P,<,0.05），但组间比较差异均无统计学意义（,P,>,0.05）。③治疗后，两组患者的WHR、BMI均明显降低（,P,<,0.05，,P,<,0.01），但组间比较差异均无统计学意义（,P,>,0.05）。④治疗后，两组患者的T、LH水平及LH/FSH比值较治疗前均降低（,P,<,0.05，,P,<,0.01），且治疗组患者的LH水平及LH/FSH比值低于对照组（,P,<,0.05）。,结论,2,蔡氏调周法能有效调节肥胖型PCOS患者的脂代谢紊乱，较好地改善其性激素水平，降低LEP水平及WHR、BMI，升高ADP水平，且无明显毒副反应。

Abstract

Objective,2,To observe the influence of Cai’s menstruation periodic treatment on lipid metabolism and the levels of serum leptin(LEP) and adiponectin(ADP) in obese patients with polycystic ovary syndrome (PCOS).,Methods,2,A total of 67 obese patients with PCOS were included and randomly divided into the treatment group (33 cases) and control group (34 cases). The patients in the treatment group were treated with Cai’s menstruation periodic treatment, and the patients in the control group were orally treated with metformin tablets. The treatment course of the two groups was 3 months. Before and after treatment, the waist-hip-ratio (WHR) and body mass index (BMI) of the two groups were calculated and compared; the levels of lipid metabolism indexes including triacylglycerol (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and free fatty acid (FFA), and the levels of LEP and ADP in the two groups were detected; the levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (T) were detected, and the LH/FSH ratio was calculated.,Results,2,①After treatment, the levels of TC and LDL in the two groups were decreased compared with those before treatment (,P,<,0.05), but with no significantly statistical differences between the two groups (,P,>,0.05). ②After treatment, the level of LEP in the two groups was decreased (,P,<,0.05) and the level of ADP was increased (,P,<,0.05), but with no significantly statistical differences between the two groups (,P,>,0.05). ③After treatment, the WHR and BMI of the two groups were significantly decreased (,P,<,0.05,P,<,0.01), but with no significantly statistical differences between the two groups (,P,>,0.05). ④After treatment, the levels of T and LH and the LH/FSH ratio in the two groups were decreased compared with those before treatment (,P,<,0.05,P,<,0.01), and the level of LH and the LH/FSH ratio in the treatment group were lower than those in the control group (,P,<,0.05).,Conclusion,2,Cai’s menstruation periodic treatment can effectively regulate the lipid metabolism disorder in obese patients with PCOS, better improve the sex hormone levels, decrease the LEP level, WHR and BMI, and increase the level of ADP, without obvious toxic and side effects.

关键词

多囊卵巢综合征肥胖蔡氏调周法中药脂代谢瘦素脂联素

Keywords

polycystic ovary syndromeobesityCai’s menstruation periodic treatmenttroditional Chinese herbal medicinelipid metabolismleptinadiponectin

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