Objective,2,To analyze the research status and hotspots of traditional Chinese medicine (TCM) treatment of osteosarcoma and to reveal the dynamic changes and development trend of research hotspots for the purpose of providing ideas and basis for the research of TCM treatment of osteosarcoma.,Methods,2,The research literature on TCM treatment of osteosarcoma in databases such as China National Knowledge Infrastructure (CNKI), Wanfang Database of China Medical Collections, and Chinese biomedical literature service system (SinoMed) was retieved from the date of database’s establishment to June 2019. Bibliometric methods were adopted to analyze and describe the basic information of the research literature (publication time, issuing institution, source of publication, fund projects, etc.). The Citespace software was used to depict and visualize the knowledge map of research hotspots, including co-occurrence analysis, cluster analysis, timeline view analysis and emergence analysis of literature keywords.,Results,2,①After screening, 197 valid articles were finally obtained, among which basic research articles were more than clinical research articles. ②The number of articles related to TCM treatment of osteosarcoma from 1988 to 2019 showed an overall upward trend, with a slow and fluctuating rise. ③Fujian University of Traditional Chinese Medicine (the main campus and affiliated institutions) published the most articles on TCM treatment of osteosarcoma. Generally speaking, there was relatively little cooperation among different regions and different universities and institutions. ④The relevant articles were published in 38 different sources, including journal articles and dissertations respectively, and the sources of publication were relatively scattered. ⑤The National Natural Science Foundation of China (NSFC) has topped the sponsorship, but less than 40% of the articles were funded. ⑥The author (first author) with the highest number of publications was Chen Yongqiang from the Shanghai Municipal Hospital of Traditional Chinese Medicine affiliated to Shanghai University of Traditional Chinese Medicine; the number of related scholars was small and they were scattered, and there was relatively little collaboration among different authors from different regions. ⑦The co-occurrence analysis and cluster analysis showed that the research hotspots of TCM treatment of osteosarcoma mainly focused on how to regulate the proliferation and apoptosis of osteosarcoma cells, and curcumin, Pien Tze Huang, and melittin were the most extensively and deeply studied. ⑧The timeline view analysis showed that the hot keyword change of TCM treatment of osteosarcoma from 2003 to 2019 was significant, and immune regulation may become the frontier research point. ⑨The emergence analysis showed that tripterine had the highest emergence rate, which surged from 2015 onwards.,Conclusions,2,The research on TCM treatment of osteosarcoma has achieved certain progress, but the overall research is still in the primary stage, and the academic cooperation among different regions and different research teams needs to be strengthened. At present, the research mainstream of TCM intervention in osteosarcoma is the research on TCM monomers, while the research on TCM syndrome standardization of osteosarcoma may be one of the key research directions in the future.