Clinical study on Sini Decoction combined with western medicine in treating lower extremity arteriosclerosis obliterans

Yudong FANG; Zhe LIU; Yuxin FAN; Wenwen LI; Zhongliang ZHANG; Qintong YANG

doi:10.16305/j.1007-1334.2021.1908054

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Clinical study on Sini Decoction combined with western medicine in treating lower extremity arteriosclerosis obliterans

更新时间：2022-08-03

- Clinical study on Sini Decoction combined with western medicine in treating lower extremity arteriosclerosis obliterans
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 6, Pages: 50-52,95(2021)
- 作者机构：
  
  1.上海中医药大学附属上海市中西医结合医院脉管科（上海　200082）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.1908054
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Yudong FANG, Zhe LIU, Yuxin FAN, et al. Clinical study on Sini Decoction combined with western medicine in treating lower extremity arteriosclerosis obliterans. [J]. Shanghai Journal of Traditional Chinese Medicine 55(6):50-52,95(2021)
DOI：

Yudong FANG, Zhe LIU, Yuxin FAN, et al. Clinical study on Sini Decoction combined with western medicine in treating lower extremity arteriosclerosis obliterans. [J]. Shanghai Journal of Traditional Chinese Medicine 55(6):50-52,95(2021) DOI： 10.16305/j.1007-1334.2021.1908054.

摘要

目的,2,观察四逆汤联合西药治疗下肢动脉硬化闭塞症的临床疗效。,方法,2,将100例下肢动脉硬化闭塞症患者随机分为对照组和治疗组，每组50例。对照组予常规西药基础治疗，治疗组在对照组治疗措施基础上加服四逆汤治疗。两组疗程均为28 d，观察临床疗效，比较症状、体征量化评分及踝肱指数（ABI）的变化情况。,结果,2,①最终完成试验者95例，治疗组48例，对照组47例。②治疗组、对照组总有效率分别为79.2%、57.4%；组间临床疗效比较，治疗组明显优于对照组（,P,<,0.05）。③治疗前后组内比较，两组皮肤温度感、皮肤色泽、疼痛、ABI、间歇性跛行距离及间歇性跛行缓解时间模块评分差异有统计学意义（,P,<,0.05）；组间治疗后比较，皮肤温度感、皮肤色泽、疼痛和ABI模块评分差异有统计学意义（,P,<,0.05），间歇性跛行距离和间歇性跛行缓解时间模块评分差异无统计学意义（,P,>,0.05）。④治疗前后组内比较，两组ABI水平差异有统计学意义（,P,<,0.05）；组间治疗后比较，ABI水平差异无统计学意义（,P,>,0.05）。,结论,2,四逆汤联合西药治疗下肢动脉硬化闭塞症的临床疗效优于单纯西药治疗，可更好地改善患者的临床症状、体征。

Abstract

Objective,2,To observe the clinical effect of Sini Decoction combined with western medicine on lower extremity arteriosclerosis obliterans (ASO).,Methods,2,A total of 100 patients with lower extremity ASO were randomly divided into control group (,n,=50) and treatment group (,n,=50). The control group was administered with conventional western medicine, while the treatment group was administered with Sini Decoction besides the conventional western medicine of the control group. The course of treatment in both groups lasted 28 days. The clinical effect was observed, and the changes in the quantitative scores of the symptoms and signs as well as the ankle-brachial index (ABI) were compared.,Results,2,①Finally, 95 patients completed the trial including 48 patients in the treatment group and 47 patients in the control group. ②The total effective rates of the treatment group and the control group were 79.2% and 57.4%, respectively. The clinical effect of the treatment group was significantly better than that of the control group (,P,<,0.05). ③The intra-group comparison before and after treatment showed that there were significant differences in the module scores of skin temperature perception, skin color, pain, ABI, intermittent claudication distance and intermittent claudication remission time in both groups (,P,<,0.05). According to the inter-group comparison after treatment, there were significant differences in the module scores of skin temperature perception, skin color, pain and ABI between the two groups (,P,<,0.05), but the module scores of intermittent claudication distance and intermittent claudication remission time showed no significant difference (,P,>,0.05). ④The intra-group comparison indicated that ABI differed significantly before and after treatment in both groups (,P,<,0.05), while the inter-group comparison indicated that the difference in ABI between the two groups after treatment was not significant (,P,>,0.05).,Conclusion,2,Compared with the single use of western medicine, the combined use of Sini Decoction with western medicine has better clinical effect on the treatment of lower extremity ASO, which can better improve the clinical symptoms and signs of patients.

关键词

四逆汤扶阳法动脉硬化闭塞症下肢血脉瘀阻证中西医结合治疗临床研究

Keywords

Sini Decoctionyang-supporting methodarteriosclerosis obliteranslower extremitystatic blood blocking blood vessels syndromeintegrated traditional Chinese and western medicine treatmentclinical research

references

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