Clinical observation of Chen’s Zhimu San combined with intravenous infusion in treatment of suspicious oligohydramnios

Feixiang HUANG; Junmiao XU; Pei HE; Xueqi CHEN; Shouzhen YAO; Xuelin GAO; Juya YING

doi:10.16305/j.1007-1334.2021.1908010

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Clinical observation of Chen’s Zhimu San combined with intravenous infusion in treatment of suspicious oligohydramnios

更新时间：2022-08-03

- Clinical observation of Chen’s Zhimu San combined with intravenous infusion in treatment of suspicious oligohydramnios
- Shanghai Journal of Traditional Chinese Medicine Vol. 55, Issue 7, Pages: 55-58(2021)
- 作者机构：
  
  1.杭州市妇产科医院（浙江　杭州　310008）
  2.浙江中医药大学附属第三医院（浙江　杭州　330106）
  3.杭州市江干区彭埠街道社区卫生服务中心（浙江　杭州　310017）
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2021.1908010
  CLC：
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Feixiang HUANG, Junmiao XU, Pei HE, et al. Clinical observation of Chen’s Zhimu San combined with intravenous infusion in treatment of suspicious oligohydramnios. [J]. Shanghai Journal of Traditional Chinese Medicine 55(7):55-58(2021)
DOI：

Feixiang HUANG, Junmiao XU, Pei HE, et al. Clinical observation of Chen’s Zhimu San combined with intravenous infusion in treatment of suspicious oligohydramnios. [J]. Shanghai Journal of Traditional Chinese Medicine 55(7):55-58(2021) DOI： 10.16305/j.1007-1334.2021.1908010.

摘要

目的,2,探讨陈氏知母散联合静脉输液治疗可疑羊水过少的临床疗效。,方法,2,纳入141例可疑羊水过少患者，随机分为西药组66例和中西医结合组75例。西药组患者给予静脉输液治疗，中西医结合组患者在静脉输液的基础上给予陈氏知母散口服，两组疗程均为7 d。治疗前后，检测所有患者的全血黏度、血浆黏度，采用B型超声检测并计算患者的羊水指数（AFI）、胎儿脐动脉血流收缩末期峰值（S）与舒张末期峰值（D）的比值（S/D比值），评估并比较两组患者的中医证候评分。,结果,2,①治疗后，两组患者的AFI升高（,P,<,0.05）、胎儿脐动脉S/D比值降低（,P,<,0.05），且中西医结合组患者的AFI高于西药组（,P,<,0.05）、胎儿脐动脉S/D比值低于西药组（,P,<,0.05）。②治疗后，中西医结合组患者的中医证候评分较治疗前明显降低（,P,<,0.05），且中西医结合组患者的评分低于西药组（,P,<,0.05）。③治疗后，中西医结合组患者的低切、中切、高切全血黏度及血浆黏度较治疗前均降低（,P,<,0.05），西药组患者的低切全血黏度及血浆黏度较治疗前亦降低（,P,<,0.05），且中西医结合组患者的低切、中切、高切全血黏度均低于西药组（,P,<,0.05）。,结论,2,与单纯静脉输液疗法比较，陈氏知母散联合静脉输液疗法治疗可疑羊水过少，可更好地降低患者的血液黏稠度，增加羊水量，改善胎儿脐动脉血流，从而调整胎盘局部的微循环。

Abstract

Objective,2,To explore the curative effect of Chen’s Zhimu San combined with intravenous infusion in the treatment of suspicious oligohydramnios.,Methods,2,A total of 141 pregnant women with suspicious oligohydramnios were included and randomly divided into the western medicine group (66 cases) and the integrated traditional Chinese and western medicine group (75 cases). The patients in the western medicine group were treated with intravenous infusion, and the patients in the integrated traditional Chinese and western medicine group were orally treated with Chen’s Zhimu San based on intravenous infusion. The treatment course was 7 days. Before and after treatment, the whole blood viscosity and plasm viscosity were detected, the amniotic fluid index (AFI) and ratio of end systolic peak (S) to end diastolic peak (D) of fetal umbilical artery blood flow (S/D ratio) were measured and calculated by B-mode ultrasonography, and the scores of Chinese medical syndrome in both groups were evaluated and compared.,Results,2,①After treatment, the AFI was increased and the fetal umbilical artery S/D ratio was decreased in the two groups (,P,<,0.05), and the AFI in the integrated traditional Chinese and western medicine group was higher than that in the western medicine group (,P,<,0.05), the fetal umbilical artery S/D ratio was lower than that in the western medicine group (,P,<,0.05). ②After treatment, the scores of Chinese medical syndrome in the integrated traditional Chinese and western medicine group were significantly decreased compared with those before treatment (,P,<,0.05), and the scores of the integrated traditional Chinese and western medicine group were lower than those of the western medicine group (,P,<,0.05). ③After treatment, the whole blood viscosity (low shear, medium shear, high shear) and plasm viscosity in the integrated traditional Chinese and western medicine group were decreased compared with those before treatment (,P,<,0.05), the whole blood viscosity (low shear) and plasm viscosity in the western medicine group were also decreased compared with those before treatment (,P,<,0.05), and the whole blood viscosity (low shear, medium shear, high shear) in the integrated traditional Chinese and western medicine group was lower than that in the western medicine group (,P,<,0.05).,Conclusion,2,Compared with intravenous infusion therapy, Chen’s Zhimu San combined with intravenous infusion therapy can better decrease the blood viscosity in the treatment of suspicious oligohydramnios, increase the amniotic fluid volume, and improve the fetal umbilical artery blood flow, thus regulate the local microcirculation of placenta.

关键词

可疑羊水过少陈氏知母散静脉输液中西医结合疗法

Keywords

suspicious oligohydramniosChen’s Zhimu Sanintravenous infusionintegrated traditional Chinese and western medicine therapy

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