Objective:To optimize the preparation process of Yugu Liaoshang Tablets and to select the optimal formulation. MethodsOn the basis of investigating the particle size of the extract, the dissolution amount of dipsacus asperosaponins in the tablets was used as the index, and the relationship among stirring speed, granulation speed and povidone K30 slurry concentration was further investigated by orthogonal test. The single factor was used to further optimize the lubricant and coating process conditions.  Results:The best prescription for Yugu Liaoshang Tablets was the extract pellets mixed with 10% lactose, 7.5% sodium carboxymethyl starch and 2.5% povidone K30, and 0.5% magnesium stearate and pressed; the coating was done with a low ethanol concentration coating solution.  Conclusion:The preparation process of Yugu Liaoshang Tablets is stable, and the moisture absorption of the tablets was improved after coating, which increased the stability of the product, and made it easier to store and transport.