Chemical constituents isolated from Sargentodoxa cuneate

ZHANG Wen; ZHOU Shuang; SUN Chengpeng; DENG Dong; CHE Jinhua; FAN Tian; MA Xiaochi; FANG Bangjiang

doi:10.16305/j.1007-1334.2020.2005176

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Chemical constituents isolated from Sargentodoxa cuneate

更新时间：2022-08-31

- Chemical constituents isolated from Sargentodoxa cuneate
- Shanghai Journal of Traditional Chinese Medicine Vol. 54, Issue 11, Pages: 85-88(2020)
- 作者机构：
  
  1. 上海中医药大学附属龙华医院急诊科,上海,200032
  2. 上海中医药大学针灸推拿学院,上海,200032
  3. 大连医科大学药学院,辽宁,大连,116044
  4. 湖北民族大学医学部,湖北,恩施,445000
- 作者简介：
- 基金信息：
- DOI：10.16305/j.1007-1334.2020.2005176
  CLC：
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ZHANG Wen, ZHOU Shuang, SUN Chengpeng, et al. Chemical constituents isolated from Sargentodoxa cuneate. [J]. Shanghai Journal of Traditional Chinese Medicine 54(11):85-88(2020)
DOI：

ZHANG Wen, ZHOU Shuang, SUN Chengpeng, et al. Chemical constituents isolated from Sargentodoxa cuneate. [J]. Shanghai Journal of Traditional Chinese Medicine 54(11):85-88(2020) DOI： 10.16305/j.1007-1334.2020.2005176.

摘要

目的：研究大血藤Sargentodoxa cuneata(Oliv.)Rehd.et Wils.茎部化学成分。方法：采用系统溶剂法对大血藤根茎进行提取,并采用硅胶柱、ODS柱和制备型HPLC等色谱技术对其进行分离纯化,根据理化性质及核磁共振波谱数据鉴定化合物的结构。结果：从大血藤的95%乙醇提取物中分离得到10个化合物,分别鉴定为省沽油香堇苷D(staphylionoside D,化合物1)、4-羟基-1-(2-硝乙基)苯4-O-(6′-O-β-D-木糖基)-β-D-葡萄糖苷[4-hydroxy-1-(2-nitroethyl)benzene 4-O-(6′-O-β-D-xylopyranosyl)-β-D-glucopyranoside,化合物2]、香草醇4-O-β-D-葡萄糖苷(vanillyl alcohol-4-O-β-D-glucopyranoside,化合物3)、3,4,5-三甲氧基苯基-β-D-葡萄糖苷(3,4,5-trimethoxyphenyl-β-D-glucopyranoside,化合物4)、异它乔糖苷(isotachioside,化合物5)、4-羟基-3,5-二甲氧基-苯酚(4-hydroxy-3,5-dimethoxy-phenol,化合物6)、2-(2′-烯丙基)2,3-苯并二氢呋喃-5-甲酸(dimethyl 2,3′-dimethoxyosoate,化合物7)、尿苷(uridine,化合物8)、丁香醛(syringaldehyde,化合物9)和5-羟基-3-甲氧基-2-(3′-甲氧基-2-甲酸酯基)-5-甲基苯基-苯甲酸甲酯(fomannoxin acid,化合物10)。结论：所有化合物均为首次从大血藤属植物中分离得到。

Abstract

Objective:To investigate the chemical constitutes from the stems of Sargentodoxa cuneata. MethodsCompounds were extracted by the method of system solvent,and isolated and purified by a combination of various chromatographic techniques,including silica gel column,ODS column,and preparative HPLC methods.Their structures were elucidated on the basis of their physiochemical property and NMR spectra. Results:Ten compounds were obtained from 95% ethanol extract of the stems of Sargentodoxa cuneata and identified as staphylionoside D,4-hydroxy-1-(2-nitroethyl)benzene 4-O-(6′-O-β-D-xylopyranosyl)-β-D-glucopyranoside,vanillyl alcohol-4-O-β-D-glucopyranoside,3,4,5-trimethoxyphenyl-β-D-glucopyranoside,isotachioside,4-hydroxy-3,5-dimethoxy-phenol,dimethyl 2,3′-dimethoxyosoate,uridine,syringaldehyde and fomannoxin acid, respectively. Conclusion:All compounds are isolated from the genus Sargentodoxa for the first time.

关键词

大血藤省沽油香堇苷D4-羟基-1-(2-硝乙基)苯4-O-(6′-O-β-D-木糖基)-β-D-葡萄糖苷香草醇4-O-β-D-葡萄糖苷化学成分

Keywords

Sargentodoxa cuneatastaphylionoside D4-hydroxy-1-(2-nitroethyl)benzene 4-O-(6′-O-β-D-xylopyranosyl)-β-D-glucopyranosidevanillyl alcohol-4-O-β-D-glucopyranosidechemical constituents

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